Cheek Advancement Flap for BCC of the Nose: The Nitrosamine Contamination During the Combined Drug Intake as Important Skin Cancer Triggering Factor
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References
- Epstein EH. Basal cell carcinomas: attack of the hedgehog. Nat Rev Cancer. 2008 Oct;8(10):743-54. doi: 10.1038/nrc2503.
- McDaniel B, Badri T, Steele RB. Basal Cell Carcinoma. [Updated 2024 Mar 13]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482439/
- Nanz L, Keim U, Katalinic A, et al. Epidemiology of Keratinocyte Skin Cancer with a Focus on Cutaneous Squamous Cell Carcinoma. Cancers (Basel). 2024 Jan 31;16(3):606. doi: 10.3390/cancers16030606.
- Zhang W, Zeng W, Jiang A, et al. Global, regional and national incidence, mortality and disability-adjusted life-years of skin cancers and trend analysis from 1990 to 2019: An analysis of the Global Burden of Disease Study 2019. Cancer Med. 2021 Jul;10(14):4905-4922. doi: 10.1002/cam4.4046.
- Tchernev G. The nitrosamine contamination in beta blockers (bisoprolol/metoprolol), ace inhibitors (lisinopril/perindopril), thiazides diuretics (hct), calcium channel blockers (amlodipine/felodipine), sartans (candesartan) and the subsequent skin cancer development and progression: apocalypse now. Georgian Med News. 2023 Apr;(337):138-145.
- Tchernev G, Kordeva S. Nitrosogenesis of skin (human) cancer- the hidden truth of a neverending story: nitrosamine contamination in olmesartan, valsartan and hct as main risk factor for the development of keratinocyte cancer. Georgian Med News. 2023 Apr;(337):63-67.
- Mansouri I, Botton J, Semenzato L, et al. N-nitrosodimethyl- amine-Contaminated Valsartan and Risk of Cancer: A Nation- wide Study of 1.4 Million Valsartan Users. J Am Heart Assoc. 2022 Dec 20;11(24):e8067. doi: 10.1161/JAHA.122.026739.
- Recommended Acceptable Intake Limits for Nitrosamine Drug Substance-Related Impurities (NDSRIs) [Internet]. FDA U.S. Food and drug administration; Updated 2024, April 9. Available from: https://www.fda.gov/regulatory-information/search-fda-guidancedocuments/updated-information-recommended-acceptable-intake-limits-nitrosamine-drug-substance-related
- Hidajat M, McElvenny DM, Ritchie P, et al. Lifetime exposure to rubber dusts, fumes and N-nitrosamines and cancer mortality in a cohort of British rubber workers with 49 years follow-up. Occup Environ Med. 2019 Apr;76(4):250-258. doi: 10.1136/oemed-2018-105181.
- Nishie K, Norred WP, Wasserman A, et al. Phototoxicity and differential hepatotoxicity as biological indicators of nitrosamine activity. Toxicol Appl Pharmacol. 1972; 23:680-91.
- Tchernev G, Dimova D. Periocular high riskbccs after additional/parallel intake oftorasemide, moxonidine and mirabegron: important links to skin cancer related(photo-) nitrosogenesis in the context ofpharmaco-oncogenesis. Georgian Med News.2024;347:70-76.
- Tchernev G, Broshtilova V, Ivanov L, et al. Drug related nitrosogenesis, photocarcinogenesis and oncopharmacogenesis of nodular melanoma: a case related analysis concerning the polycontamination of the polymedication with valsartan/hydrochlorothiazide and bisoprolol. Georgian Med News. 2024 Feb;(347):24-27.
- Tchernev G, Poterov G, Malev V. Sartans and Melanoma: Valsartan Induced Multiple Primary Cutaneous Melanomas: first Description in the Medical Literature!. Clin Res Dermatol Open Access, 2020, 7(4): 1-3. DOI: 10.15226/2378-1726/7/4/001123.
- Cohen OG, Taylor M, Mohr C, et al. Antihypertensive Medications and Risk of Melanoma and Keratinocyte Carcinomas: A Systematic Review and Meta-Analysis. JID Innov. 2024 Mar 23;4(3):100272. doi: 10.1016/j.xjidi.2024.100272.
- Hou A, Li Y, Shadyab AH, et al. Photosensitizing antihypertensive medication and risk of skin cancer among postmenopausal women. J Dtsch Dermatol Ges. 2024 Feb;22(2):186-194. doi: 10.1111/ddg.15281.
- Kuntz T, Grimm A, Hofmann SC, et al. Hydrochlorothiazide and increased risk of atypical fibroxanthoma and pleomorphic dermal sarcoma. J Dtsch Dermatol Ges. 2024 Apr;22(4):513-519. doi: 10.1111/ddg.15379.
- N-Nitroso Glimepiride [Internet], Cleanchem Laboratories LLP, Available from: https://www.cleanchemlab.com/N-Nitro-so-Glimepiride
- Tchernev G, Kordeva S. Basal cell carcinoma development after use of metformin – potential role of nitrosamines as enhancing factors. Port J Dermatol Venereol. 2023; 80:65-68.9.
- Tchernev G, Broshtilova V. (NDMA) Metformin and (NTTP) sitagliptin induced cutaneous melanomas: links to nitrosogenesis, nitroso-photocarcinogenesis, oncopharmacogenesis and the metabolic reprogramming. Georgian Med News. 2024 Mar;(348):132-143.
- Sharma AK, Rastogi S, Goyal RK. Retrospective analysis of neoplasms in patients using angiotensin receptor blockers. Sci Rep. 2024 Jul 9;14(1):15774. doi: 10.1038/s41598-024-64867-y.
- Recalls of Angiotensin II Receptor Blockers (ARBs) including Valsartan, Losartan and Irbesartan [Internet]. FDA U.S. Food and drug administration; Available from: https://www.fda.gov/drugs/drug-safety-and-availability/recalls-angiotensin-ii-receptor-blockers-arbs-including-valsartan-losartan-and-irbesartan
- Tchernev G, Temelkova I. Valsartan/hydrochlorothiazide induced prostate carcinoma in a patient who subsequently developed melanoma. J Biol Regul Homeost Agents. 2019 Jul-Aug;33(4):1125-1127.
- Tchernev G, Poterov G. Drug Induced Cancers: Simultaneously Development of Cutaneous Melanoma, Colon Carcinoma and Kaposi Sarcoma under Valsartan/Hydrochlorothiazide. Clin Res Dermatol Open Access. 2020.
- Tchernev G, Poterov G. Antihypertensive Drugs and Cancer: Simultaneously Development of Choroidal Melanoma and Colon Carcinoma after Administration with Valsartan/Hydrochlorothiazide. Clin Res Dermatol Open Access 2020, 7(4):1-4. DOI: 10.15226/2378-1726/7/4/001125
- Kordeva S, Marchev S, Batashki I, Tchernev G. SCC of the Nose and Metatypical BCC of the Shoulder Developing during Treatment with Valsartan/Chlortalidone: Nitrosamine Contamination as Main Skin Cancer Triggering Factor. Clin Res Dermatol Open Access. 2023, 10(1): 1-4. 10.15226/2378-1726/10/1/001151.
- Mochizuki H, Nagazawa Y, Arimoto-Kobayashi S. Genotoxicity and the stability of N-nitrosomorpholine activity following UVA irradiation. Mutat Res Genet Toxicol Environ Mutagen. 2024 Jan; 893:503721. doi: 10.1016/j.mrgentox.2023.503721.
- Schmidtsdorff S, Neumann J, Schmidt AH, Parr MK. Prevalence of nitrosamine contaminants in drug samples: Has the crisis been overcome? Arch Pharm (Weinheim). 2023 Feb;356(2):e2200484. doi: 10.1002/ardp.202200484.
- White CM. Ranitidine’s N-nitrosodimethylamine Problem May be Tip of the Iceberg. JAMA Netw Open. 2021 Jan 4;4(1):e2035158. doi: 10.1001/jamanetworkopen.2020.35158.
- Sarlak S, Lalou C, Amoedo ND, Rossignol R. Metabolic reprogramming by tobacco-specific nitrosamines (TSNAs) in cancer. Semin Cell Dev Biol. 2020 Feb;98:154-166. doi: 10.1016/j.semcdb.2019.09.001.
- Cerci FB. Versatility of advancement flaps for nasal reconstruction following Mohs‘ micrographic surgery. An Bras Dermatol. 2018 Sep-Oct;93(5):719-722. doi: 10.1590/abd1806-4841.20187284.
- Salmon PJ. Repair of the nasal sidewall. Br J Dermatol. 2014 Sep;171 Suppl 2:17-22. doi: 10.1111/bjd.13205.
- Vinciullo C. Reconstructing the nasal dorsum. Br J Dermatol. 2014 Sep;171 Suppl 2:7-16. doi: 10.1111/bjd.13238.
- Krishnan R, Garman M, Nunez-Gussman J, Orengo I. Advancement flaps: a basic theme with many variations. Dermatol Surg. 2005 Aug;31(8 Pt 2):986-94. doi: 10.1111/j.1524-4725.2005.31823.
- Himeles JR, Criscito MC, Kellner R, et al. Applying Occam’s Razor and Descending the Reconstructive Ladder: The Modified Cheek Advancement Flap for Reconstruction of Nasal Defects. Facial Plast Surg. 2023 Apr;39(2):180-184. doi: 10.1055/a-1939-4132.
- Stanfill SB, Hecht SS, Joerger AC, et al. From cultivation to cancer: formation of N-nitrosamines and other carcinogens in smokeless tobacco and their mutagenic implications. Crit Rev Toxicol. 2023 Nov;53(10):658-701. doi: 10.1080/10408444.2023.2264327.
- Almskou A, Buus NH, Steffensen SGC. Geographical differences in hydrochlorothiazide associated risk of skin cancer balanced against disability related to hypertensive heart disease. Am J Hypertens. 2024 Aug 8:hpae101. doi: 10.1093/ajh/hpae101.
- Tchernev G. Nitrosamines in commonly prescribed anti-hypertensives and the (un)controlled drug-induced skin cancer: simultaneous development of cutaneous melanoma and multiple bcc after concomitant administration of bisoprolol and furosemide. Georgian Med News. 2023 Sep;(342):149-151.
- Manchuri KM, Shaik MA, Gopireddy VSR, et al. Analytical Methodologies to Detect N-Nitrosamine Impurities in Active Pharmaceutical Ingredients, Drug Products and Other Matrices. Chem Res Toxicol. 2024 Aug 19. doi: 10.1021/acs. chemrestox.4c00234.
Language: English
Page range: 67 - 75
Submitted on: Sep 23, 2024
Accepted on: Oct 7, 2024
Published on: May 15, 2025
Published by: Sofia Medical University
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
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© 2025 G. Tchernev, S. Kordeva, published by Sofia Medical University
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