Have a personal or library account? Click to login
Insights Into Atopic Dermatitis – From Pathogenesis to Therapy Cover

Insights Into Atopic Dermatitis – From Pathogenesis to Therapy

Open Access
|May 2023

References

  1. Akdis CA, Akdis M, Bieber T, et al. Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus Report. J Allergy Clin Immunol, 2006, 118:152-169.
  2. Illi S, von Mutius E, Lau S, et al. The natural course of atopic dermatitis from birth to age 7 years and the association with asthma. J Allergy Clin Immunol, 2004, 113:925-931.
  3. Silverberg JI. Atopic Dermatitis in Adults. Med Clin North Am. 2020 Jan; 104(1):157-176. doi: 10.1016/j.mcna.2019.08.009).
  4. Bieber T. Atopic Dermatitis. N Engl J Med, 2008, 358:1483-1494.
  5. Bhattacharya N, Sato WJ, Kelly A, et al. Epidermal Lipids: Key Mediators of Atopic Dermatitis Pathogenesis. Trends Mol Med, 2019, 25(6):551-562. https://doi.org/10.1016/j.molmed.2019.04.001
  6. Schultz LF. Atopic dermatitis: a genetic-epidemiologic study in a population-based twin sample. J Am Acad Dermatol, 1993, 28(5 Pt 1):719–723.
  7. Rawlings AV, Harding CR. Moisturization and skin barrier function. Dermatol Ther, 2004, 17(Suppl 1):43–48.
  8. Kezic S, O’Regan GM, Lutter R, et al. Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency. J Allergy Clin Immunol, 2012, 129:1031-1039.
  9. Brauweiler AM, Bin L, Kim BE, et al. Filaggrin dependent secretion of sphingomyelinase protects against Staphylococcal alphatoxin-induced keratinocyte death. J Allergy Clin Immunol, 2013, 131:421-427.
  10. Silverberg JI. Atopic Dermatitis in Adults. Med Clin N Am, 2020, 104:157-176. https://doi.org/10.1016/j.mcna.2019.08.009
  11. Mohiuddin M, Ramamoorthy P, Reynolds PR, et al. Increased compound heterozygous filaggrin mutations in severe atopic dermatitis in the United States. J Allergy Clin Immunol Pract, 2013, 1:534-536.
  12. Heine G, Hoefer N, Franke A, et al. Association of vitamin D receptor gene polymorphisms with severe atopic dermatitis in adults. Br J Dermatol, 2013, 168(4):855–858.
  13. Berker T, Visscher D, Gooris GS, et al. Topically applied ceramides interact with the stratum corneum lipid matrix in compromised ex vivo skin. Pharm Res, 2018, 35(3):48. doi: 10.1007/s11095-017-2288-y
  14. Schmid-Wendtner MH, Korting HC. The pH of the skin surface and its impact on the barrier function. Skin Pharmacol Physiol, 2006, 19:296-302.
  15. Schafer L, Kragballe K. Abnormalities in epidermal lipid metabolism in patients with atopic dermatitis. J Invest Dermatol, 1991, 96:10–15.
  16. McGirt LY, Beck LA. Innate immune defects in atopic dermatitis. J Allergy Clin Immunol, 2006, 118:202-208.
  17. Howell MD, Wollenberg A, Gallo RL, et al. Cathelicidin deficiency predisposes to eczema herpeticum. J Allergy Clin Immunol 2006;117: 836-41.
  18. Butcher EC, Picker LJ. Lymphocyte homing and homeostasis. Science, 1996, 272:60-66.
  19. Picker LJ, Martin RJ, Trumble A, et al. Differential expression of lymphocyte homing receptors by human memory/effector T cells in pulmonary versus cutaneous immune effector sites. Eur J Immunol, 1994, 24:1269-1277.
  20. Novak N, Bieber T. Allergic and nonallergic forms of atopic diseases. J Allergy Clin Immunol, 2003, 112:252-262.
  21. Kerschenlohr K, Darsow U, Burgdorf WH, et al. Lessons from atopy patch testing in atopic dermatitis. Curr Allergy Asthma Rep, 2004, 4:285-289.
  22. Spergel JM, Mizoguchi E, Brewer JP, et al. Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice. J Clin Invest, 1998, 101:1614-1622.
  23. Traidl-Hoffmann C, Mariani V, Hochrein H, et al. Pollen-associated phytoprostanes inhibit dendritic cell interleukin-12 production and augment T helper type 2 cell polarization. J Exp Med, 2005, 201:627-636.
  24. Clark RA, Chong B, Mirchandani N, et al. The vast majority of CLA+ T cells are resident in normal skin. J Immunol, 2006, 176:4431-4439.
  25. Soumelis V, Reche PA, Kanzler H, et al. Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat Immunol, 2002, 3:673-680.
  26. Grewe M, Walther S, Gyufko K, et al. Analysis of the cytokine pattern expressed in situ in inhalant allergen patch test reactions of atopic dermatitis patients. J Invest Dermatol, 1995, 105:407-410.
  27. Tazawa T, Sugiura H, Sugiura Y, et al. Relative importance of IL-4 and IL-13 in lesional skin of atopic dermatitis. Arch Dermatol Res, 2004, 295(11):459–464.
  28. Trautmann A, Akdis M, Kleemann D, et al. T cell-mediated Fas-induced keratinocyte apoptosis plays a key pathogenetic role in eczematous dermatitis. J Clin Invest, 2000, 106:25-35.
  29. Esaki H, Brunner PM, Renert-Yuval Y, et al. Early-onset pediatric atopic dermatitis is TH2 but also TH17 polarized in skin. J Allergy Clin Immunol, 2016, 138(6):1639–1651.
  30. Aichberger KJ, Mittermann I, Reininger R, et al. Hom s 4, an IgE-reactive autoantigen belonging to a new subfamily of calcium-binding proteins, can induce Th cell type 1-mediated autoreactivity. J Immunol, 2005, 175:1286-1294.
  31. Leung DYM. Pathogenesis of atopic dermatitis. J Allergy Clin Immunol, 1999, 104 (Suppl):S99-108.
  32. Kramer MS, Kakuma R. Maternal dietary antigen avoidance during pregnancy or lactation, or both, for preventing or treating atopic disease in the child. Evid Based Child Health, 2014, 9:447–483.
  33. Khan A, Adalsteinsson J, Whitaker-Worth DL. Atopic dermatitis and nutrition. Clin Dermatol, 2022, 40(2):135-144. https://doi.org/10.1016/j.clindermatol.2021.10.006
  34. Leung DYM, Guttman-Yassky E. Deciphering the complexities of atopic dermatitis: Shifting paradigms in treatment approaches. J Allergy Clin Immunol, 2014, 134(4):769-779. doi: 10.1016/j.jaci.2014.08.008
  35. Lever R, Hadley K, Downey D, et al. Staphylococcal colonization in atopic dermatitis and the effect of topical mupirocin therapy. Br J Dermatol, 1988, 119:189-198.
  36. Bunikowski R, Mielke M, Skarabis H, et al. Prevalence and role of serum IgE antibodies to the Staphylococcus aureus– derived superantigens SEA and SEB in children with atopic dermatitis. J Allergy Clin Immunol, 1999, 103:119-124.
  37. Nickoloff BJ, Naidu Y. Perturbation of epidermal barrier function correlates with initiation of cytokine cascade in human skin. J Am Acad Dermatol, 1994, 30:535-546.
  38. Nakajima S, Igyarto BZ, Honda T, et al. Langerhans cells are critical in epicutaneous sensitization with protein antigen via thymic stromal lymphopoietin receptor signaling. J Allergy Clin Immunol, 2012, 129:1048-1055.
  39. Ghoreschi K, Laurence A, O’Shea JJ. Janus kinases in immune cell signaling. Immunol Rev, 2009, 228(1):273-287.
  40. Suga H, Sato S. Novel topical and systemic therapies in atopic dermatitis. Immunol Med, 2019, 42(2):84-93.
  41. Jimenez JL, Punzon C, Navarro J, et al. Phosphodiesterase 4 inhibitors prevent cytokine secretion by T lymphocytes by inhibiting nuclear factor-kappa B and nuclear factor of activated T cells activation. J Pharmacol Exp Ther, 2001, 299(2):753-759.
  42. Grewe SR, Chan SC, Hanifin JM. Elevated leukocyte cyclic AMP-phosphodiesterase in atopic disease: a possible mechanism for cyclic AMP-agonist hyporesponsiveness. J Allergy Clin Immunol, 1982, 70(6):452-457.
  43. Nakajima S, Igyarto BZ, Honda T, et al. Langerhans cells are critical in epicutaneous sensitization with protein antigen via thymic stromal lymphopoietin receptor signaling. J Allergy Clin Immunol, 2012, 129:1048-1055.
  44. Dominguez O, Plaza AM, Alvaro M. Relationship Between Atopic Dermatitis and Food Allergy. Curr Pediatr Rev. 2020;16(2):115-22.
  45. Kajosaari M. Atopy prophylaxis in high-risk infants. Prospective 5-year follow-up study of children with six months exclusive breastfeeding and solid food elimination. Adv Exp Med Biol, 1991, 310:453–458.
  46. Bergmann RL, Diepgen TL, Kuss O, et al. Breastfeeding duration is a risk factor for atopic eczema. Clin Exp Allergy, 2002; 32:205–209.
  47. Khan A, Adalsteinsson J, Whitaker-Worth DL. Atopic dermatitis and nutrition. Clin Dermatol, 2022, 40(2): 135-144. https://doi.org/10.1016/j.clindermatol.2021.10.006
  48. Zhao M, Shen C, Ma L. Treatment efficacy of probiotics on atopic dermatitis, zooming in on infants: a systematic review and meta-analysis. Int J Dermatol, 2018, 57 :635–641.
  49. Pessi T, Sütas Y, Hurme M, et al. Interleukin-10 generation in atopic children following oral lactobacillus rhamnosus GG. Clin Exp Allergy, 2000, 30:1804–1808.
DOI: https://doi.org/10.2478/amb-2023-0022 | Journal eISSN: 2719-5384 | Journal ISSN: 0324-1750
Language: English
Page range: 73 - 80
Submitted on: Nov 2, 2022
Accepted on: Dec 28, 2022
Published on: May 14, 2023
Published by: Sofia Medical University
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2023 K. Papadakis, T. Handjieva-Darlenska, R. Tafradjiiska-Hadjiolova, H. Nocheva, published by Sofia Medical University
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.