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Association of Insulin Resistance with Bone Mineral Density and Fracture Risk in Non-Diabetic Postmenopausal Women Cover

Association of Insulin Resistance with Bone Mineral Density and Fracture Risk in Non-Diabetic Postmenopausal Women

By: R. Dimitrova and  K. Hristozov  
Open Access
|May 2023

References

  1. Thrailkill KM, Lumpkin CKJr, Bunn RC et al. Is insulin an anabolic agent in bone? Dissecting the diabetic bone for clues. Am J Physiol Endocrinol Metab. 2005; 289(5): E735-E745.
  2. Fulzele K, Riddle RC, DiGirolamo DJ et al. Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition. Cell. 2010; 142(2): 309-319.
  3. Barrett-Connor E, Kritz-Silverstein D. Does hyperinsulinemia preserve bone? Diabetes Care. 1996; 19: 1388–92.
  4. Abrahamsen B, Rohold A, Henriksen JE et al. Correlations between insulin sensitivity and bone mineral density in nondiabetic men. Diabet Med. 2000; 17: 124-9.
  5. Hanley DA, Brown JP, Tenenhouse A et al. Associations among disease conditions, bone mineral density, and prevalent vertebral deformities in men and women 50 years of age and older: cross-sectional results from the Canadian Multicentre Osteoporosis Study. J Bone Miner Res. 2003; 18: 784-90.
  6. Ma L, Oei L, Jiang L et al. Association between bone mineral density and type 2 diabetes mellitus: a meta-analysis of observational studies. Eur J Epidemiol. 2012; 27: 319-32.
  7. Wei J, Ferron M, Clarke CJ et al. Bone-specific insulin resistance disrupts whole-body glucose homeostasis via decreased osteocalcin activation. J Clin Invest. 2014; 124(4): 1-13.
  8. Bonds DE, Larson JC, Schwartz AV et al. Risk of fracture in women with type 2 diabetes: the Women’s Health Initiative Observational Study. J Clin Endocrinol Metab. 2006; 91(9): 3404-3410.
  9. Janghorbani M, Van Dam RM, Willett WC et al. Systematic review of type 1 and type 2 diabetes mellitus and risk of fracture. Am J Epidemiol. 2007;166(5): 495-505.
  10. Koh WP, Wang R, Ang LW et al. Diabetes and risk of hip fracture in the Singapore Chinese Health Study. Diabetes Care. 2010; 33(8): 1766-1770.
  11. Looker AC, Eberhardt MS, Saydah SH. Diabetes and fracture risk in older U.S. adults. Bone. 2016; 82: 9-15.
  12. Napoli N, Strotmeyer ES, Ensrud KE et al. Fracture risk in diabetic elderly men: the MrOS study. Diabetologia. 2014; 57(10): 2057-2065.
  13. Strotmeyer ES, Cauley JA, Schwartz AV et al. Nontraumatic fracture risk with diabetes mellitus and impaired fasting glucose in older white and black adults: the health, aging, and body composition study. Arch Intern Med. 2005;165(14): 1612-1617.
  14. Dennison EM, Syddall HE, Aihie Sayer A et al. Type 2 diabetes mellitus is associated with increased axial bone density in men and women from the Hertfordshire Cohort Study: evidence for an indirect effect of insulin resistance? Diabetologia. 2004; 47(11): 1963-1968.
  15. Shanbhogue VV, Finkelstein JS, Bouxsein ML et al. Association between insulin resistance and bone structure in nondiabetic postmenopausal women. J Clin Endocrinol Metab. 2016; 101(8): 3114-3122.
  16. Stolk RP, Van Daele PL, Pols HA et al. Hyperinsulinemia and bone mineral density in an elderly population: The Rotterdam Study. Bone. 1996; 18(6): 545-549.
  17. Srikanthan P, Crandall CJ, Miller-Martinez D et al. Insulin resistance and bone strength: findings from the study of midlife in the United States. J Bone Miner Res. 2014; 29(4): 796-803.
  18. Haffner SM, Bauer RL. The association of obesity and glucose and insulin concentrations with bone density in premenopausal and postmenopausal women. Metabolism. 1993; 42(6): 735-738.
  19. Reid IR, Evans MC, Cooper GJ et al. Circulating insulin levels are related to bone density in normal postmenopausal women. Am J Physiol. 1993;265(4 Pt 1): E655-E659.
  20. Ishii S, Cauley JA, Crandall CJ et al. Diabetes and femoral neck strength: findings from the Hip Strength Across the Menopausal Transition Study. J Clin Endocrinol Metab. 2012; 97(1): 190-197.
  21. Shin D, Kim S, Kim KH et al. Association between insulin resistance and bone mass in men. J Clin Endocrinol Metab. 2014; 99(3): 988-995.
  22. Fasipe OJ, Ayoade OG, Enikuomehin AC. Severity grade assessment classifications for both insulin resistance syndrome and status of pancreatic beta cell function in clinical practice using homeostasis model assessment method indices. Can J Diabetes. 2020; 44(7): 663-669.
  23. https://www.omnicalculator.com/health/homa-ir
  24. Napoli N, Conte C, Pedone C et al. Insulin Resistance and Fracture Risk. J Clin Endocrinol Metab. 2019; 104(8): 3303-3310.
  25. Yang J, Hong N, Shim J-S et al. Association of Insulin Resistance with Lower Bone Volume and Strength Index of the Proximal Femur in Nondiabetic Postmenopausal Women. J Bone Metab 2018; 25: 123-132.
  26. Campillo-Sánchez F, Usategui-Martín R, Ruiz-de Temiño Á et al. Relationship between Insulin Resistance (HOMA-IR), Trabecular Bone Score (TBS), and Three-Dimensional Dual- Energy X-ray Absorptiometry (3D-DXA) in Non-Diabetic Postmenopausal Women. J Clin Med. 2020; 9(6): 1732.
  27. Wei J, Karsenty G. Bone as a site of insulin resistance in type 2 diabetes. BMC Proc. 2012; 6: 74.
  28. Pramojanee S N, Phimphilai M, Kumphune S et al. Decreased jaw bone density and osteoblastic insulin signaling in a model of obesity. J Dent Res. 2013; 92: 560-5.
  29. De Liefde II, van der Klift M, de Laet CE et al. Bone mineral density and fracture risk in type-2 diabetes mellitus: the Rotterdam Study. Osteoporos Int. 2005; 16(12): 1713-1720.
  30. Holmberg AH, Nilsson PM, Nilsson JA et al. The association between hyperglycemia and fracture risk in middle age. A prospective, population-based study of 22,444 men and 10,902 women. J Clin Endocrinol Metab. 2008; 93(3): 815-822.
  31. Chen C, Chen Q, Nie B et al. Trends in Bone Mineral Density, Osteoporosis, and Osteopenia Among U.S. Adults With Prediabetes, 2005-2014. Diabetes Care. 2020; 43(5): 1008-1015.
DOI: https://doi.org/10.2478/amb-2023-0016 | Journal eISSN: 2719-5384 | Journal ISSN: 0324-1750
Language: English
Page range: 26 - 32
Submitted on: Jan 9, 2023
Accepted on: Feb 22, 2023
Published on: May 14, 2023
Published by: Sofia Medical University
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2023 R. Dimitrova, K. Hristozov, published by Sofia Medical University
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.