Abstract
Objective
The study was performed to evaluate the novel potential of red rose extract to inhibit SARS-CoV-2 spike protein-Ace2 receptor interaction in vitro.
Methods
ACE2 receptors were His-labelled, and the interaction was studied by chemiluminescence after the addition of anti-His HRP and HRP substrate. The inhibition of SARS-CoV-2 and ACE2 was assessed in a dose-dependent sequence.
Results
The 50% inhibitory concentration was observed at 0.75 percent v/v of the rose extract, and the 90% inhibition was seen at about 1.8 percent v/v. Steam inhalation or nebulization could be simple methods of delivering rose extracts to the lower respiratory tract and pulmonary tissues.
Conclusion
Rose extracts have a potential for inhibition of SARS-CoV-2 and ACE2 receptor in vitro, which could add beneficial effects in Covid-19 treatment. Further tests need to be performed to study their therapeutic benefits in vivo.