Have a personal or library account? Click to login

Regulatory Role of microRNAs in Tumor Angiogenesis

Open Access
|May 2020

References

  1. 1. Lei Z, Li B, Yang Z et al. Regulation of HIF-1α and VEGF by miR-20b Tunes Tumor Cells to Adapt to the Alteration of Oxygen Concentration. PLoS ONE 2009,4(10): e7629.10.1371/journal.pone.0007629276409019893619
  2. 2. Chou J, Lin JH, Brenot A et al. GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression. Nature cell biology. 2013,15. 10.1038/ncb2672.10.1038/ncb2672366085923354167
  3. 3. Long J, Wang Y, Wang W et al. Identification of microRNA-93 as a novel regulator of vascular endothelial growth factor in hyperglycemic conditions. J Biol Chem. 2010 Jul 23;285(30):23457-6510.1074/jbc.M110.136168290633620501654
  4. 4. Liu B, Peng XC, Zheng XL et al. MiR-126 restoration down-regulate VEGF and inhibit the growth of lung cancer cell lines in vitro and in vivo. Lung Cancer. 2009 Nov;66(2):169-75.10.1016/j.lungcan.2009.01.01019223090
  5. 5. Hao Y, Yang J, Yin S et al. The synergistic regulation of VEGF-mediated angiogenesis through miR-190 and target genes. RNA. 2014 Aug;20(8):1328-36.10.1261/rna.044651.114410575624962367
  6. 6. Wang R, Zhao N, Li S et al. MicroRNA-195 suppresses angio-genesis and metastasis of hepatocellular carcinoma by inhibiting the expression of VEGF, VAV2, and CDC42. Hepatology. 2013 Aug;58(2):642-53.10.1002/hep.2637323468064
  7. 7. Ghosh A, Dasgupta D, Ghosh A, et al. MiRNA199a-3p suppresses tumor growth, migration, invasion and angiogenesis in hepatocellular carcinoma by targeting VEGFA, VEGFR1, VEGFR2, HGF and MMP2. Cell Death Dis. 2017; 8:e2706.10.1038/cddis.2017.123538652928358369
  8. 8. Choi YC, Yoon S, Jeong Y et al. Regulation of vascular endothelial growth factor signaling by miR-200b. Mol Cells. 2011 Jul;32(1):77-82.10.1007/s10059-011-1042-2388766321544626
  9. 9. Zhu X, Er K, Mao C et al. miR-203 suppresses tumor growth and angiogenesis by targeting VEGFA in cervical cancer. Cell Physiol Biochem. 2013;32(1):64-73.10.1159/00035012523867971
  10. 10. Yan JJ, Zhang YN, Liao JZ et al. MiR-497 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting VEGFA and AEG-1. Oncotarget. 2015 Oct 6;6(30):29527-42.10.18632/oncotarget.5012474574426336827
  11. 11. Wang W, Ren F, Wu Q et al. MicroRNA-497 suppresses angiogenesis by targeting vascular endothelial growth factor A through the PI3K/AKT and MAPK/ERK pathways in ovarian cancer. Oncol Rep. 2014 Nov;32(5):2127-33.10.3892/or.2014.343925176450
  12. 12. Zhou B, Ma R, Si W et al. MicroRNA-503 targets FGF2 and VEGFA and inhibits tumor angiogenesis and growth. Cancer Lett. 2013 Jun 10;333(2):159-69.10.1016/j.canlet.2013.01.02823352645
  13. 13. Cheng J, Chen Y, Zhao P et al. Downregulation of miRNA-638 promotes angiogenesis and growth of hepatocellular carcinoma by targeting VEGF. Oncotarget. 2016 May 24;7(21):30702-11.10.18632/oncotarget.8930505871127120793
  14. 14. Png KJ, Halberg N, Yoshida M, Tavazoie SF. A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells. Nature. 2011 Dec 14;481(7380):190-4.10.1038/nature1066122170610
  15. 15. Shi ZM, Wang XF, Qian X et al. MiRNA-181b suppresses IGF-1R and functions as a tumor suppressor gene in gliomas. RNA. 2013 Apr;19(4):552-60.10.1261/rna.035972.112367726523431408
  16. 16. Xu Q, Jiang Y, Yin Y et al. A regulatory circuit of miR-148a/152 and DNMT1 in modulating cell transformation and tumor angiogenesis through IGF-IR and IRS1. J Mol Cell Biol. 2013 Feb;5(1):3-13.10.1093/jmcb/mjs049357005222935141
  17. 17. Zhou Y, Li S, Li J, Wang D, Li Q. Effect of microRNA-135a on Cell Proliferation, Migration, Invasion, Apoptosis and Tumor Angiogenesis Through the IGF-1/PI3K/Akt Signaling Pathway in Non-Small Cell Lung Cancer. Cell Physiol Biochem. 2017;42(4):1431-1446.10.1159/00047920728715819
  18. 18. Chai ZT, Kong J, Zhu XD et al. MicroRNA-26a inhibits angiogenesis by down-regulating VEGFA through the PIK3C2α/ Akt/HIF-1α pathway in hepatocellular carcinoma. PLoS One. 2013 Oct 23;8(10):e77957.10.1371/journal.pone.0077957380679624194905
  19. 19. Yin Y, Yan ZP, Lu NN et al. Downregulation of miR-145 associated with cancer progression and VEGF transcriptional activation by targeting N-RAS and IRS1. Biochim Biophys Acta. 2013 Feb;1829(2):239-47.10.1016/j.bbagrm.2012.11.00623201159
  20. 20. Zheng Y, Li S, Ding Y et al. The role of miR-18a in gastric cancer angiogenesis. Hepatogastroenterology. 2013 Oct;60(127):1809-13.
  21. 21. Shi ZM, Wang J, Yan Z et al. MiR-128 inhibits tumor growth and angiogenesis by targeting p70S6K1. PLoS One. 2012;7(3):e32709.10.1371/journal.pone.0032709330771422442669
  22. 22. Qing Xu, Ling-Zhi Liu, Xu Qian et al. MiR-145 directly targets p70S6K1 in cancer cells to inhibit tumor growth and angio-genesis, Nucleic Acids Research, 2012;40(2),761-774.10.1093/nar/gkr730325813321917858
  23. 23. Guan B, Wu K, Zeng J et al. Tumor-suppressive microRNA-218 inhibits tumor angiogenesis via targeting the mTOR component RICTOR in prostate cancer. Oncotarget. 2017 Jan 31;8(5):8162-8172.10.18632/oncotarget.14131535239128030804
  24. 24. Ma L, Young J, Prabhala H et al. miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat Cell Biol. 2010 Mar;12(3):247-56.10.1038/ncb2024284554520173740
  25. 25. Liu L, Jiang H, Zhao J, Wen H. MiRNA-16 inhibited oral squamous carcinoma tumor growth in vitro and in vivo via suppressing Wnt/β-catenin signaling pathway. Onco Targets Ther. 2018 Aug 23; 11:5111-5119.10.2147/OTT.S153888611279930197522
  26. 26. Yang C, Xu Y, Cheng F et al. miR-1301 inhibits hepatocellular carcinoma cell migration, invasion, and angiogenesis by decreasing Wnt/β-catenin signaling through targeting BCL9. Cell Death Dis. 2017 Aug 17;8(8):e2999.10.1038/cddis.2017.356559654728817119
  27. 27. Kumar B, Yadav A, Lang J et al. Dysregulation of microRNA-34a expression in head and neck squamous cell carcinoma promotes tumor growth and tumor angiogenesis. PLoS One. 2012;7(5):e37601.10.1371/journal.pone.0037601335826522629428
  28. 28. Zhou Q, Zhu Y, Wei X et al. MiR-590-5p inhibits colorectal cancer angiogenesis and metastasis by regulating nuclear factor 90/vascular endothelial growth factor A axis. Cell Death Dis. 2016 Oct 13;7(10):e2413.10.1038/cddis.2016.306513397527735951
  29. 29. Liu LZ, Li C, Chen Q et al. MiR-21 induced angiogenesis through AKT and ERK activation and HIF-1α expression. PLoS One. 2011 Apr 22;6(4):e19139.10.1371/journal.pone.0019139308134621544242
  30. 30. Mao G, Liu Y, Fang X et al. Tumor-derived microRNA-494 promotes angiogenesis in non-small cell lung cancer. Angio-genesis. 2015 Jul;18(3):373-82.10.1007/s10456-015-9474-526040900
  31. 31. Lou W, Liu J, Gao Y et al. MicroRNAs in cancer metastasis and angiogenesis. Oncotarget. 2017 Dec 11;8(70):115787-115802.10.18632/oncotarget.23115577781329383201
  32. 32. Zhou Y, Xu Q, Shang J, Lu L, Chen G. Crocin inhibits the migration, invasion, and epithelial-mesenchymal transition of gastric cancer cells via miR-320/KLF5/HIF-1α signaling. J Cell Physiol. 2019 Mar 9.10.1002/jcp.2841830851060
  33. 33. Yamakuchi M, Yagi S, Ito T, Lowenstein CJ. MicroRNA-22 Regulates Hypoxia Signaling in Colon Cancer Cells. PLoS ONE 2011,6(5): e20291.10.1371/journal.pone.0020291310032621629773
  34. 34. Yamakuchi M, Lotterman CD, Bao C et al. P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis. Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6334-9.10.1073/pnas.0911082107285197920308559
  35. 35. Zhang H, Pu J, Qi T et al. MicroRNA-145 inhibits the growth, invasion, metastasis and angiogenesis of neuroblastoma cells through targeting hypoxia-inducible factor 2 alpha. Oncogene. 2014 Jan 16;33(3):387-97.10.1038/onc.2012.57423222716
  36. 36. Kong W, He L, Richards EJ et al. Upregulation of miRNA-155 promotes tumour angiogenesis by targeting VHL and is associated with poor prognosis and triple-negative breast cancer. Oncogene. 2014 Feb 6;33(6):679-89.10.1038/onc.2012.636392533523353819
  37. 37. Serocki M, Bartoszewska S, Janaszak-Jasiecka A et al. miRNAs regulate the HIF switch during hypoxia: a novel therapeutic target. Angiogenesis. 2018 May;21(2):183-202.10.1007/s10456-018-9600-2587820829383635
  38. 38. He T, Qi F, Jia L et al. MicroRNA-542-3p inhibits tumour angiogenesis by targeting angiopoietin-2. J Pathol. 2014 Apr;232(5):499-508.10.1002/path.432424403060
  39. 39. Fan C, Lin Y, Mao Y et al. MicroRNA-543 suppresses colorectal cancer growth and metastasis by targeting KRAS, MTA1 and HMGA2. Oncotarget. 2016 Apr 19;7(16):21825-39.10.18632/oncotarget.7989500832626968810
  40. 40. Würdinger T, Tannous BA, Saydam O et al. miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cells. Cancer Cell. 2008 Nov 4;14(5):382-93.10.1016/j.ccr.2008.10.005259716418977327
DOI: https://doi.org/10.2478/amb-2020-0012 | Journal eISSN: 2719-5384 | Journal ISSN: 0324-1750
Language: English
Page range: 67 - 72
Submitted on: May 1, 2019
Accepted on: Jun 1, 2019
Published on: May 21, 2020
Published by: Sofia Medical University
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2020 T. Popov, S. Giragosyan, V. Petkova, Tz. Marinov, M. Belitova, J. Rangachev, R. Kaneva, V. Mitev, published by Sofia Medical University
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.