References
- Abd El-Aziz YS, Leck LYW, Jansson PJ et al. (2021) Emerging role of autophagy in the development and progression of oral squamous cell carcinoma. Cancers (Basel) 13:6152.
https://doi.org/10.3390/cancers13246152 - Abotaleb M, Samuel SM, Varghese E et al. (2018) Flavonoids in cancer and apoptosis. Cancers (Basel) 11:28.
https://doi.org/10.3390/cancers11010028 - Ahn C, Jeung EB (2023) Endocrine-disrupting chemicals and disease endpoints. Int J Mol Sci 24:5342.
https://doi.org/10.3390/ijms24065342 - Alexandra T, Marina IM, Daniela M et al. (2020) Autophagy – a hidden but important actor on oral cancer scene. Int J Mol Sci 21:9325.
https://doi.org/10.3390/ijms21239325 - Arani R, Mohammadpour H, Moosavi M et al. (2022) The role of autophagy-related proteins of Beclin-1/BECN1, LC3II, and p62/SQSTM1 in melanoma tumors. Asian Pacific J Cancer Biol 6:263–272.
https://doi.org/10.31557/apjcb.2021.6.4.263-272 - Buoso E, Masi M, Racchi M et al. (2020) Endocrine-disrupting chemicals’ (EDCs) effects on tumour microenvironment and cancer progression: emerging contribution of RACK1. Int J Mol Sci 21:9229.
https://doi.org/10.3390/ijms21239229 - Carter RJ, Milani M, Butterworth M et al. (2019) Exploring the potential of BH3 mimetic therapy in squamous cell carcinoma of the head and neck. Cell Death Dis 10:912.
https://doi.org/10.1038/s41419-019-2150-8 - Croitoru MD, Miklos A, Fogarasi E et al. (2016) Evaluation of the ingestion of parabens during the use of dental care products by healthy human volunteers. Farmacia 64:594–598.
- Das S, Shukla N, Singh SS et al. (2021) Mechanism of interaction between autophagy and apoptosis in cancer. Apoptosis 26:512–533.
https://doi.org/10.1007/s10495-021-01687-9 - Debnath J, Gammoh N, Ryan KM (2023) Autophagy and autophagy-related pathways in cancer. Nat Rev Mol Cell Biol 24:560–575.
https://doi.org/10.1038/s41580-023-00585-z - Eskandari E, Eaves CJ (2022) Paradoxical roles of caspase-3 in regulating cell survival, proliferation, and tumorigenesis. J Cell Biol 221:e202201159.
https://doi.org/10.1083/jcb.202201159 - Feng Y, He D, Yao Z et al. (2014) The machinery of macroautophagy. Cell Res 24:24–41.
https://doi.org/10.1038/cr.2013.168 - Font-Díaz J, Jiménez-Panizo A, Caelles C et al. (2021) Nuclear receptors: lipid and hormone sensors with essential roles in the control of cancer development. Semin Cancer Biol 73:58–75.
https://doi.org/10.1016/j.semcancer.2020.12.007 - Fuentes N, Silveyra P (2019) Estrogen receptor signaling mechanisms. Adv Protein Chem Struct Biol 116:135–170.
https://doi.org/10.1016/bs.apcsb.2019.01.001 - Grsic K, Opacic IL, Sitic S et al. (2016) The prognostic significance of estrogen receptor β in head and neck squamous cell carcinoma. Oncol Lett 12:3861–3865.
https://doi.org/10.3892/ol.2016.5142 - Hager E, Chen J, Zhao L (2022) Minireview: parabens exposure and breast cancer. Int J Environ Res Public Health 19:1873.
https://doi.org/10.3390/ijerph19031873 - Heshiki W, Tomihara K, Yamazaki M et al. (2015) Constitutive activation of caspase-3 in non-apoptotic oral squamous cell carcinoma cells. J Cancer Sci Ther 7:2.
https://doi.org/10.4172/1948-5956.1000328 - Hu YJ, Zhong JT, Gong L et al. (2020) Autophagy-related Beclin 1 and head and neck cancers. OncoTargets Ther 13:6213–6227.
https://doi.org/10.2147/OTT.S256072 - Johnson DE, Burtness B, Leemans CR et al. (2020) Head and neck squamous cell carcinoma. Nat Rev Dis Primers 6:92.
https://doi.org/10.1038/s41572-020-00224-3 - Kong Q, Liang Y, He Q et al. (2020) Autophagy inhibits TLR4-mediated invasiveness of oral cancer cells via the NF-κB pathway. Oral Dis 26:1165–1174.
https://doi.org/10.1111/odi.13355 - Kranjčević JK, Čonkaš J, Ozretić P (2024) The role of estrogen and estrogen receptors in head and neck tumors. Cancers (Basel) 16:1575.
https://doi.org/10.3390/cancers16081575 - Liu D, Zhou LQ, Cheng Q et al. (2023) Developing a pyroptosis-related gene signature to better predict the prognosis and immune status of patients with head and neck squamous cell carcinoma. Front Genet 13:988606.
https://doi.org/10.3389/fgene.2022.988606 - Maiuri MC, Zalckvar E, Kimchi A et al. (2007) Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 8:741–752.
https://doi.org/10.1038/nrm2239 - Mukhopadhyay S, Panda PK, Sinha N et al. (2014) Autophagy and apoptosis: where do they meet? Apoptosis 19:555–566.
https://doi.org/10.1007/s10495-014-0967-2 - Peña-Oyarzún D, Reyes M, Hernández-Cáceres MP et al. (2020) Role of autophagy in the microenvironment of oral squamous cell carcinoma. Front Oncol 10:602661.
https://doi.org/10.3389/fonc.2020.602661 - Pereira AR, Simões M, Gomes IB (2023) Parabens as environmental contaminants of aquatic systems affecting water quality and microbial dynamics. Sci Total Environ 905:167332.
https://doi.org/10.1016/j.scitotenv.2023.167332 - Qin C, Lu Y, Zhang H et al. (2022) Biological roles and clinical significance of estrogen and androgen receptors in head and neck cancers. J Cancer 13:2189–2199.
https://doi.org/10.7150/jca.66707 - Schneider CA, Rasband WS, Eliceiri KW (2012) NIH image to ImageJ: 25 years of image analysis. Nat Methods 9:671–675.
https://doi.org/10.1038/nmeth.2089 - Shanle EK, Xu W (2010) Selectively targeting estrogen receptors for cancer treatment. Adv Drug Deliv Rev 62:1265–1276.
https://doi.org/10.1016/j.addr.2010.08.001 - Shu CW, Chang HT, Wu CS et al. (2016) RelA-mediated BECN1 expression is required for reactive oxygen species-induced autophagy in oral cancer cells exposed to low-power laser irradiation. PLoS One 11:e0160586.
https://doi.org/10.1371/journal.pone.0160586 - Siegel RL, Kratzer TB, Giaquinto AN et al. (2025) Cancer statistics, 2025. CA Cancer J Clin 75:10–45.
https://doi.org/10.3322/caac.21871 - Siegel RL, Miller KD, Jemal A (2020) Cancer statistics, 2020. CA Cancer J Clin 70:7–30.
https://doi.org/10.3322/caac.21590 - Song S, Tan J, Miao Y et al. (2017) Crosstalk of autophagy and apoptosis: involvement of the dual role of autophagy under ER stress. J Cell Physiol 232:2977–2984.
https://doi.org/10.1002/jcp.25785 - Takamura A, Komatsu M, Hara T et al. (2011) Autophagy-deficient mice develop multiple liver tumors. Genes Dev 25:795–800.
https://doi.org/10.1101/gad.2016211 - Wang Y, Wang C, Tang H et al. (2013) Decrease of autophagy activity promotes malignant progression of tongue squamous cell carcinoma. J Oral Pathol Med 42:557–564.
https://doi.org/10.1111/jop.12049 - Weng J, Wang C, Wang Y et al. (2014) Beclin1 inhibits proliferation, migration and invasion in tongue squamous cell carcinoma cell lines. Oral Oncol 50:983–990.
https://doi.org/10.1016/j.oraloncology.2014.06.020 - Wirawan E, Vande Walle L, Kersse K et al. (2010) Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria. Cell Death Dis 1:e18.
https://doi.org/10.1038/cddis.2009.16 - Yang J, Nie J, Ma X et al. (2019) Targeting PI3K in cancer: mechanisms and advances in clinical trials. Mol Cancer 18:26.
https://doi.org/10.1186/s12943-019-0954-x - Yun CW, Lee SH (2018) The roles of autophagy in cancer. Int J Mol Sci 19:3466.
https://doi.org/10.3390/ijms19113466 - Zhang HW, Hu JJ, Fu RQ et al. (2018) Flavonoids inhibit cell proliferation and induce apoptosis and autophagy through downregulation of PI3Kγ mediated PI3K/AKT/mTOR/p70S6K/ULK signaling pathway in human breast cancer cells. Sci Rep 8:11255.
https://doi.org/10.1038/s41598-018-29308-7 - Zhang L, Zhang W, Wang YF et al. (2015) Dual induction of apoptotic and autophagic cell death by targeting survivin in head neck squamous cell carcinoma. Cell Death Dis 6:e1771.
https://doi.org/10.1038/cddis.2015.139 - Zhou M, Liu X, Li Z et al. (2018) Caspase-3 regulates the migration, invasion, and metastasis of colon cancer cells. Int J Cancer 143:921–930.
https://doi.org/10.1002/ijc.31374