References
- Peppas NA, Hilt JZ, Khademhosseini A, Langer R. Hydrogels in biology and medicine: from molecular principles to bionanotechnology. Adv Mater 2006;18:1345–60. doi: 10.1002/adma.200501612
- Li CC, Chauhan A. Ocular transport model for ophthalmic delivery of timolol through p-HEMA contact lenses. J Drug Deliv Sci Technol 2007;17:69–79. doi: 10.1016/S1773-2247(07)50010-9
- Curcio M, Cirillo G, Parisi OI, Iemma F, Spizzirri UG, Altimari I, Picci N, Puoci F. Poly (2-hydroxyethyl methacrylate)-quercetin conjugate as biomaterial in ophthalmology: an “ab initio” study. J Funct Biomater 2011;2:1–17. doi: 10.3390/jfb2010001
- Davaran S, Fazeli H, Ghamkhari A, Rahimi F, Molavi O, Anzabi M, Salehi R. Synthesis and characterization of novel P(HEMA-LA-MADQUAT) micelles for co-delivery of methotrexate and Chrysin in combination cancer chemotherapy. J Biomater Sci Polym 2018;29:1265–86. doi: 10.1080/09205063.2018.1456026
- Johnson RP, Jeong YI, Choi E, Chung CW, Kang DH, Oh SO, Suh H, Kim I. Biocompatible poly(2-hydroxyethyl methacrylate)-b-poly(L-histidine) hybrid materials for ph-sensitive intracellular anticancer drug delivery. Adv Funct Mater 2012;7:1058–68. doi: 10.1002/adfm.201102756
- Bakan B, Gülcemal S, Akgöl S, Hoet PHM, Karabay Yavaşoğlu NÜ. Synthesis, characterization and toxicity assessment of a new polymeric nanoparticle, L-glutamic acid-g-p(HEMA). Chem Biol Interact 2020;315(5):108870. doi: 10.1016/j.cbi.2019.108870
- Bakan B, Kayhan CT, Karayildirim CK, Dagdeviren M, Gulcemal S, Yıldırım Y, Akgol S, Karabay Yavasoglu NU. Synthesis, characterization, toxicity and in vivo imaging of lysine graft polymeric nanoparticles. J Polymer Res 2019;26(10):239. doi: 10.1007/s10965-019-1901-7
- Avcıbaşı U, Türkyarar T, Karadağ A, Bakan B, Karabay Yavaşoğlu NU, Kusat K, Akgöl S, Gülcemal D, Tekin V, Biber Müftüler FZ, Topal G, Parlak Y, Gumuser FG. Preparation of a 99mTc-labeled graft polymer and its in vitro and in vivo evaluation. J Radioanal Nucl Chem 2021;329:511–25. doi: 10.1007/s10967-021-07817-6
- Guler C, Gulcemal S, Guner A, Akgol S, Karabay Yavasoglu NU. Polymeric nanoparticles tryptophan-graft-p(HEMA): a study on synthesis, characterization, and toxicity. Polymer Bull 2023;80:10973–96. doi: 10.1007/s00289-022-04607-2
- OECD. Test No. 425: Acute Oral Toxicity: Up-and-Down-Procedure [displayed 12 September 2023]. Available at https://www.oecd.org/env/test-no-425-acute-oral-toxicity-up-and-down-procedure-9789264071049-en.htm
- OECD. Test No. 407: Repeated Dose 28-day Oral Toxicity Study in Rodents [displayed 12 September 2023]. Available at https://www.oecd.org/env/test-no-407-repeated-dose-28-day-oral-toxicity-study-in-rodents-9789264070684-en.htm
- OECD. Test No. 474: Mammalian Erythrocyte Micronucleus Test [displayed 12 September 2023]. Available at https://www.oecd.org/env/test-no-474-mammalian-erythrocyte-micronucleus-test-9789264264762-en.htm
- Schmid W. The Micronucleus test. Mutat Res 1975;31:9–15. doi: 10.1016/0165-1161(75)90058-8
- Wu F, Tamhane M, Morris ME. Pharmacokinetics, lymph node uptake, and mechanistic PK model of near-infrared dye-labeled bevacizumab after IV and SC administration in mice. AAPS J 2012;14:252–61. doi: 10.1208/s12248-012-9342-9
- McAteer MA, Sibson NR, von Zur Muhlen C, Schneider JE, Lowe AS, Warrick N, Channon KM, Anthony DC, Choudhury RP. In vivo magnetic resonance imaging of acute brain inflammation using microparticles of iron oxide. Nat Med 2007;13:1253–8. doi: 10.1038/nm1631
- Sanvicens N, Marco MP. Multifunctional nanoparticles - properties and prospects for their use in human medicine. Trends Biotechnol 2008;26:425–33. doi: 10.1016/j.tibtech.2008.04.005
- He C, Hu Y, Yin L, Tang C, Yin C. Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles. Biomaterials 2010;31:3657–66. doi: 10.1016/j.biomaterials.2010.01.065
- Radwan SE, Sokar MS, Abdelmonsif DA, El-Kamel AH. Mucopenetrating nanoparticles for enhancement of oral bioavailability of furosemide: in vitro and in vivo evaluation/sub-acute toxicity study. Int J Pharm 2017;526:366–79. doi: 10.1016/j.ijpharm.2017.04.072
- Des Rieux A, Fievez V, Garinot M, Schneider YJ, Preat V. Nanoparticles as potential oral delivery systems of proteins and vaccines: a mechanistic approach. J Control Release 2006;116:1−27. doi: 10.1016/j.jconrel.2006.08.013
- Silva-Santana G, Bax JC, Fernandes DCS, Bacellar DTL, Hooper C, Dias AASO, Silva CB, de Souza AM, Ramos S, Santos RA, Pinto TR, Ramão MA, Mattos-Guaraldi AL. Clinical hematological and biochemical parameters in Swiss, BALB/c, C57BL/6 and B6D2F1 Mus musculus. Animal Model Exp Med 2020;3:304–15. doi: 10.1002/ame2.12139
- Malonne H, Eeckman F, Fontaine D, Otto A, Vos LD, Moës A, Fontaine J, Amighi K. Preparation of poly(N-isopropylacrylamide) copolymers and preliminary assessment of their acute and subacute toxicity in mice. Eur J Pharm Biopharm 2005;61:188–94. doi: 10.1016/j.ejpb.2005.05.007
- Shrivastava R, Raza S, Yadav A, Kushwaha P, Flora SJ. Effects of sub-acute exposure to TiO2, ZnO and Al2O3 nanoparticles on oxidative stress and histological changes in mouse liver and brain. Drug Chem Toxicol 2014;37:336–47. doi: 10.3109/01480545.2013.866134
- Magaye RR, Yue X, Zou B, Shi H, Yu H, Liu K, Lin X, Xu J, Yang C, Wu A, Zhao J. Acute toxicity of nickel nanoparticles in rats after intravenous injection. Int J Nanomedicine 2014;9:1393–402. doi: 10.2147/IJN.S56212
- Karlsson HL, Di Bucchianico S, Collins AR, Dusinska M. Can the comet assay be used reliably to detect nanoparticle-induced genotoxicity? Environ Mol Mutagen 2015;56:82–96. doi: 10.1002/em.21933
- Durner J, Walther UI, Zaspel J, Hickel R, Reichl FX. Metabolism of TEGDMA and HEMA in human cells. Biomaterials 2010;31:818–23. doi: 10.1016/j.biomaterials.2009.09.097
- Arnida, Janat-Amsbury MM, Ray A, Peterson CM, Ghandehari H. Geometry and surface characteristics of gold nanoparticles influence their biodistribution and uptake by macrophages. Eur J Pharm Biopharm 2011;77:417–23. doi: 10.1016/j.ejpb.2010.11.010