Have a personal or library account? Click to login
Genotoxic and genoprotective effects of 1,4-dihydropyridine derivatives: a brief review Cover

Genotoxic and genoprotective effects of 1,4-dihydropyridine derivatives: a brief review

Archives of Industrial Hygiene and Toxicology
Volume 74 (2023): Issue 1 (March 2023)
By: Elina Leonova,  Nadezhda Ryabokon,  Evita Rostoka,  Vitalijs Borisovs,  Astrida Velena,  Egils Bisenieks,  Gunars Duburs,  Maija Dzintare,  Roza Goncharova and  Nikolajs Sjakste  
Open Access
|Apr 2023

Figures & Tables

Figure 1

Chemical structure of 1,4-DHP derivatives included in this review
Chemical structure of 1,4-DHP derivatives included in this review

Figure 2

Protective effects of nitrendipine against pTZ57R DNA plasmid damage caused by Fenton reaction products. The pTZ57R DNA plasmid (1.4 μg) was incubated for 30 min with 0.003 % H2O2 in 0.01 mmol/L FeSO4 with no or 5, 10, 25, 50 or 100 µmol/L nitrendipine And electrophoresed following the standard procedure. NK – negative control
Protective effects of nitrendipine against pTZ57R DNA plasmid damage caused by Fenton reaction products. The pTZ57R DNA plasmid (1.4 μg) was incubated for 30 min with 0.003 % H2O2 in 0.01 mmol/L FeSO4 with no or 5, 10, 25, 50 or 100 µmol/L nitrendipine And electrophoresed following the standard procedure. NK – negative control

Figure 3

Protective effects of AV-153-Na (50 nmol/L) against DNA oxidative damage caused by the DUX4 protein in the HeLa cell line. *p<0.05 vs DUX4. ###p<0.001 vs DUX4 + peroxynitrite. A.U. – arbitrary units; GFP – transfection control
Protective effects of AV-153-Na (50 nmol/L) against DNA oxidative damage caused by the DUX4 protein in the HeLa cell line. *p<0.05 vs DUX4. ###p<0.001 vs DUX4 + peroxynitrite. A.U. – arbitrary units; GFP – transfection control

Comparison of some properties of studied 1,4-DHP derivatives (11, 12, 15, 20, 25)

1,4-DHP derivativeDNA binding constant (UV/VIS spectroscopy) (M-1)Stern-Volmer binding constant (EtBr extrusion) (M-1)DNA binding constant (spectrofluorimetry) (M-1)Effect on hydroxyl radical production (EPR; %)Peroxynitrite decomposition time compared to controlDecrease in DNA damage in HeLa cells by peroxynitrite after pre-incubation with 10 nmol/L of a 1,4-DHP (%)
AV-153-Na7.21328×1049.4×1044.40×10596.80.7550
AV-153-Ca 1.7×1054.04×105 3.4457
AV-153-Mg 2.3×1055.43×105 7.52NS
AV-153-Li 9.9×1043.32×105 3.48NS
AV-153-K 8.7×1042.70×105 3.1319
AV-153-Rb 8.9×1043.07×105 3.0014
AV-154-NaNo binding 98.70.29NS
Carbatone1.09×102 100N/A
Metcarbatone0.82×102 3.8×10231.4
Etcarbatone0.54×102 9.5×10298.3
Propcarbatone1.11×102 86.4
Styrylcarbatone1.9×103?1.4×104106
GlutapyroneNo binding 27
Cerebrocrast 2.2×103 8.6129
Etaftorone 2.2527*
Fenoftorone 2.28
DOI: https://doi.org/10.2478/aiht-2023-74-3707 | Journal eISSN: 1848-6312 | Journal ISSN: 0004-1254
Journal RSS Feed
Language: English, Croatian, Slovenian
Page range: 1 - 7
Submitted on: Jan 1, 2023
Accepted on: Mar 1, 2023
Published on: Apr 4, 2023
Published by: Institute for Medical Research and Occupational Health
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
1,4-DHP,
AV-153,
diludine,
DNA binding,
carbatones,
glutapyrone
Related subjects:
Medicine,
Basic medical science,
Basic medical science, other

© 2023 Elina Leonova, Nadezhda Ryabokon, Evita Rostoka, Vitalijs Borisovs, Astrida Velena, Egils Bisenieks, Gunars Duburs, Maija Dzintare, Roza Goncharova, Nikolajs Sjakste, published by Institute for Medical Research and Occupational Health
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Volume 74 (2023): Issue 1 (March 2023)Next article