The effects of simvastatin and fenofibrate on malondialdehyde and reduced glutathione concentrations in the plasma, liver, and brain of normolipidaemic and hyperlipidaemic rats

Figures & Tables

Variable	Source	Control^a	Simvastatin^a(10 mg/kg/day)	P value^b(95 % CI)^c	Control^a	Simvastatin^a(50 mg/kg/day)	P value^b(95 % CI)^c
Variable	Source	Control^a	MDA (μmol/L)	Plasma	Control^a	0.26±0.051(n=8)	0.24±0.046(n=8)	0.471(-0.05–0.08)	0.30±0.236(n=7)	0.24±0.036(n=6)	0.044(-0.14–0.06)
Liver	105.2±15.12(n=6)	92.3±19.26(n=10)		0.166(-33.31–6.32)	103.6±17.94(n=8)	104.8±22.54(n=8)	0.909(-20.65–23.04)
Brain	2.67±0.204(n=8)	1.11±0.231(n=10)		<0.001(-1.77–1.33)	2.28±0.508(n=8)	1.80±0.218(n=6)	0.050(-0.97–0.01)
GSH (μg/mL)	Plasma	57.3±17.68(n=6)	47.4±15.81(n=9)	0.324(-30.81–10.96)	51.0±17.68(n=8)	47.7±26.80(n=7)	0.778(-28.32–21.61)
	Liver	133.5±21.24(n=6)	218.1±43.03(n=5)	0.002(39.80–129.6)	229.0±36.05(n=6)	258.0±135.2(n=6)	0.623(-96.57–43.02)
	Brain	17.2±4.61(n=8)	22.1±9.08(n=10)	0.179(-2.52–12.47)	20.2±4.23(n=8)	23.6±5.01(n=9)	0.152(-1.41–8.24)

Variable	Source	Control^a	Fenofibrate^a(30 mg/kg/day)	P value^b(95 % CI)^c	Control^a	Fenofibrate^a(50 mg/kg/day)	P value^b(95 % CI)^c
MDA (μmol/L)	Plasma	0.33±0.127(n=5)	0.20±0.033(n=8)	0.017(-0.23–0.03)	0.31±0.048(n=8)	0.18±0.022(n=8)	<0.001(-0.17–0.08)
	Liver	62.2±14.43(n=7)	62.4±15.37(n=10)	0.971(-34.18–14.22)	85.0±10.70(n=8)	71.1±11.95(n=8)	0.188(-23.18–7.57)
	Brain	3.51±0.596(n=8)	3.30±0.40(n=10)	0.404(-0.69–0.29)	2.89±1.018(n=8)	2.20±0.13(n=7)	0.120(-1.30–0.09)
GSH (μ/mL)	Plasma	69.6±20.85(n=5)	76.5±15.63(n=4)	0.602(-22.93–36.68)	70.4±12.23(n=6)	92.4±18.32(n=7)	0.030(2.60–41.41)
	Liver	71.8±36.16(n=8)	33.3±17.71(n=9)	0.013(-67.33–9.57)	72.6±16.31(n=6)	29.2±10.27(n=10)	<0.001(-57.51–29.24)
	Brain	16.7±2.54(n=7)	15.2±3.54(n=9)	0.349(-4.95–1.87)	20.6±5.58(n=8)	23.5±2.57(n=10)	0.169(-1.34–7.03)

Variable	Source	Control^a	Simvastatin^a(50 mg/kg/day)	P value^b(95 % CI)^c	Fenofibrate^a(30 mg/kg/day)	P value^b(95 % CI)^c
MDA (μmol/L)	Plasma	0.39±0.114(n=6)	0.40±0.036(n=6)	0.960(-0.11–0.09)	0.26±0.036(n=7)	0.009(0.04–0.24)
	Liver	92.1±30.00(n=6)	100.4±19.45(n=6)	0.828(-46.89–30.43)	82.8±31.26(n=7)	0.774(-27.96–46.55)
	Brain	9.7±1.67(n=6)	8.6±2.42(n=6)	0.641(-2.32–4.61)	13.5±3.08(n=6)	0.032(-7.26–0.33)
GSH (μ/mL)	Plasma	251.7±127.4(n=4)	224.2±57.58(n=5)	0.845(-117.2–172.2)	304.6±0.033(n=4)	0.593(-205.5–99.61)
	Liver	59.4±22.00(n=6)	33.0±24.04(n=5)	0.045(0.57–52.34)	12.2±5.98(n=8)	0.001(24.13–70.30)
	Brain	8.9±1.73(n=6)	9.1±1.80(n=6)	0.876(-3.26–2.28)	9.1±2.30(n=7)	0.847(-3.19–2.14)