Table 1
The effects of simvastatin (10 mg/kg and 50 mg/kg daily for 3 weeks) on MDA and GSH levels in the plasma, liver, and brain of normolipidaemic rats
| Variable | Source | Controla | Simvastatina (10 mg/kg/day) | P valueb (95 % CI)c | Controla | Simvastatina (50 mg/kg/day) | P valueb (95 % CI)c |
|---|---|---|---|---|---|---|---|
| MDA (μmol/L) | Plasma | 0.26±0.051 (n=8) | 0.24±0.046 (n=8) | 0.471 (-0.05–0.08) | 0.30±0.236 (n=7) | 0.24±0.036 (n=6) | 0.044 (-0.14–0.06) |
| Liver | 105.2±15.12 (n=6) | 92.3±19.26 (n=10) | 0.166 (-33.31–6.32) | 103.6±17.94 (n=8) | 104.8±22.54 (n=8) | 0.909 (-20.65–23.04) | |
| Brain | 2.67±0.204 (n=8) | 1.11±0.231 (n=10) | <0.001 (-1.77–1.33) | 2.28±0.508 (n=8) | 1.80±0.218 (n=6) | 0.050 (-0.97–0.01) | |
| GSH (μg/mL) | Plasma | 57.3±17.68 (n=6) | 47.4±15.81 (n=9) | 0.324 (-30.81–10.96) | 51.0±17.68 (n=8) | 47.7±26.80 (n=7) | 0.778 (-28.32–21.61) |
| Liver | 133.5±21.24 (n=6) | 218.1±43.03 (n=5) | 0.002 (39.80–129.6) | 229.0±36.05 (n=6) | 258.0±135.2 (n=6) | 0.623 (-96.57–43.02) | |
| Brain | 17.2±4.61 (n=8) | 22.1±9.08 (n=10) | 0.179 (-2.52–12.47) | 20.2±4.23 (n=8) | 23.6±5.01 (n=9) | 0.152 (-1.41–8.24) |
Table 2
The effects of fenofibrate (30 mg/kg and 50 mg/kg daily for 3 weeks) on MDA and GSH levels in the plasma, liver, and brain of normolipidaemic rats
| Variable | Source | Controla | Fenofibratea (30 mg/kg/day) | P valueb (95 % CI)c | Controla | Fenofibratea (50 mg/kg/day) | P valueb (95 % CI)c |
|---|---|---|---|---|---|---|---|
| MDA (μmol/L) | Plasma | 0.33±0.127 (n=5) | 0.20±0.033 (n=8) | 0.017 (-0.23–0.03) | 0.31±0.048 (n=8) | 0.18±0.022 (n=8) | <0.001 (-0.17–0.08) |
| Liver | 62.2±14.43 (n=7) | 62.4±15.37 (n=10) | 0.971 (-34.18–14.22) | 85.0±10.70 (n=8) | 71.1±11.95 (n=8) | 0.188 (-23.18–7.57) | |
| Brain | 3.51±0.596 (n=8) | 3.30±0.40 (n=10) | 0.404 (-0.69–0.29) | 2.89±1.018 (n=8) | 2.20±0.13 (n=7) | 0.120 (-1.30–0.09) | |
| GSH (μ/mL) | Plasma | 69.6±20.85 (n=5) | 76.5±15.63 (n=4) | 0.602 (-22.93–36.68) | 70.4±12.23 (n=6) | 92.4±18.32 (n=7) | 0.030 (2.60–41.41) |
| Liver | 71.8±36.16 (n=8) | 33.3±17.71 (n=9) | 0.013 (-67.33–9.57) | 72.6±16.31 (n=6) | 29.2±10.27 (n=10) | <0.001 (-57.51–29.24) | |
| Brain | 16.7±2.54 (n=7) | 15.2±3.54 (n=9) | 0.349 (-4.95–1.87) | 20.6±5.58 (n=8) | 23.5±2.57 (n=10) | 0.169 (-1.34–7.03) |
Table 3
The effects of simvastatin (50 mg/kg daily for 3 weeks) and fenofibrate (30 mg/kg daily for 3 weeks) on MDA and GSH levels in the plasma, liver, and brain of hyperlipidaemic rats
| Variable | Source | Controla | Simvastatina (50 mg/kg/day) | P valueb (95 % CI)c | Fenofibratea (30 mg/kg/day) | P valueb (95 % CI)c |
|---|---|---|---|---|---|---|
| MDA (μmol/L) | Plasma | 0.39±0.114 (n=6) | 0.40±0.036 (n=6) | 0.960 (-0.11–0.09) | 0.26±0.036 (n=7) | 0.009 (0.04–0.24) |
| Liver | 92.1±30.00 (n=6) | 100.4±19.45 (n=6) | 0.828 (-46.89–30.43) | 82.8±31.26 (n=7) | 0.774 (-27.96–46.55) | |
| Brain | 9.7±1.67 (n=6) | 8.6±2.42 (n=6) | 0.641 (-2.32–4.61) | 13.5±3.08 (n=6) | 0.032 (-7.26–0.33) | |
| GSH (μ/mL) | Plasma | 251.7±127.4 (n=4) | 224.2±57.58 (n=5) | 0.845 (-117.2–172.2) | 304.6±0.033 (n=4) | 0.593 (-205.5–99.61) |
| Liver | 59.4±22.00 (n=6) | 33.0±24.04 (n=5) | 0.045 (0.57–52.34) | 12.2±5.98 (n=8) | 0.001 (24.13–70.30) | |
| Brain | 8.9±1.73 (n=6) | 9.1±1.80 (n=6) | 0.876 (-3.26–2.28) | 9.1±2.30 (n=7) | 0.847 (-3.19–2.14) |