Protective effects of resveratrol against fumonisin B1-induced liver toxicity in mice

Groups	AST (U/L)	ALT (mg/dL)
Control (saline 14 days)	89.51±7.87^a	51.62±8.99^a
Resveratrol (10 mg/kg)	88.30±7.75^a	40.66±3.22^a
FB₁ (2.25 mg/kg, qad, 14 days)	623.62±150.52^b	368.00±119.16^b
FB₁ +resveratrol	207.99±34.93^a	121.11±23.50^a

1a, b – statistically significant (P<0.05) differences between the groups are marked with different letters in superscript. ALT – alanine aminotransferase; AST – aspartate aminotransferase; qad – every other day

Table 2

Mean (±standard error) liver TAS in the control, resveratrol, FB₁, and FB₁ +resveratrol groups receiving IP treatment for 14 days

Groups	TAS (mmol Trolox eq./L)
Control (saline 14 days)	2.58±0.33^b
FB₁ (2.25 mg/kg qad, 14 days)	1.53±0.07^a
Resveratrol (10 mg/kg)	2.69±0.25^b
FB ₁+resveratrol	2.15±0.20^ab

1a, b – statistically significant (P<0.05) differences between the groups are marked with different letters in superscript. TAS – total antioxidant status; qad – every other day

Table 3

Mean (±standard error) liver TOS in the control, resveratrol, FB₁, and FB₁ +resveratrol groups receiving IP treatment for 14 days

Groups	TOS (μmol H₂O₂ eq./L)
Control (saline 14 days)	38.40±1.20^a
FB₁ (2.25 mg/kg qad, 14 days)	49.77±2.50^b
Resveratrol (10 mg/kg)	34.92±2.88^a
FB₁+Resveratrol	40.86±2.71^ab

1a, b – statistically significant (P<0.05) differences between the groups are marked with different letters in superscript. TAS – total oxidant status; qad – every other day

Table 4

Mean (±standard error) serum TSA levels in the control, resveratrol, FB₁ and FB₁ +resveratrol groups receiving IP treatment for 14 days

Groups	Sialic acid (mg/dL)
Control (saline 14 days)	1358.37±76.38^a
FB₁ (2.25 mg/kg qad, 14 days)	1594.99±33.65^b
Resveratrol (10 mg/kg)	1411.41±37.87^a
FB₁ + Resveratrol	1513.99±25.95^ab

1a, b – statistically significant (P<0.05) differences between the groups are marked with different letters in superscript. TSA – total sialic acid; qad – every other day

Comparison of liver histologies between the study groups. (A) normal liver histology in a mouse from the control group; (B) severe hyperaemia (white arrows), inflammatory cell infiltrations (black arrow), and megalokaryosis (arrow head) in a mouse from the FB₁ group; (C) normal liver histology in a mouse from the resveratrol group; (D) normal liver histology in a mouse from the FB1+resveratrol group. Scale bar=50 µm

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DOI: https://doi.org/10.2478/aiht-2023-74-3648 | Journal eISSN: 1848-6312 (formerly 0004-1254) | Journal ISSN: 0004-1254

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Language: English, Croatian

Page range: 115 - 119

Submitted on: Apr 1, 2022

Accepted on: May 1, 2023

Published on: Jun 26, 2023

Published by: Institute for Medical Research and Occupational Health

In partnership with: Paradigm Publishing Services

Keywords:

ALT,

AST,

liver damage,

oxidative stress,

total antioxidant status,

total oxidant status,

total sialic acid

Related subjects:

Medicine,

Basic medical science,

Basic medical science, other

© 2023 Rıza Yalçın, Asım Kart, Özlem Özmen, Esra Zeybek, published by Institute for Medical Research and Occupational Health
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Volume 74 (2023): Issue 2 (June 2023)

Protective effects of resveratrol against fumonisin B1-induced liver toxicity in mice

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Table 2

Table 3

Table 4

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