UGT enzymes and their drug substrates (3, 8)
| Enzymes | Substrates |
|---|---|
| UGT1A1 | atazanavir, R-carvedilol, etoposide, β-oestradiol, ezetimibe, SN-38 (active metabolite of irinotecan) |
| UGT1A3 | ezetimibe, telmisartan |
| UGT1A4 | amitriptyline, lamotrigine, 1-OH midazolam, olanzapine, trifluoperazine |
| UGT1A6 | deferiprone, paracetamol, serotonin |
| UGT1A9 | edaravone, entacapone, indomethacin, mycophenolic acid, R-oxazepam, paracetamol, propofol, sorafenib |
| UGT2B7 | aldosterone, chloramphenicol, codeine, diclofenac, efavirenz, epirubicin, fenofibrate, flurbiprofen, morphine, naloxone, naproxen, zidovudine |
| UGT2B15 | dabigatran, lorazepam, R-methadone, S-oxazepam |
| UGT2B17 | testosterone, vorinostat |
UGT2B7 c_-161C>T genotype frequencies in the Croatian population and data on European populations (35, 36)
| Gene - allele | Genotype | Croatian populationa | European population | CEUb | FINb | GBRb | IBSb | TSIb |
|---|---|---|---|---|---|---|---|---|
| UGT(rs76682582B7 c.-161) C>T | C/C | 0.240 | 0.250 | 0.232 | 0.333 | 0.220 | 0.271 | 0.196 |
| C/T | 0.509 | 0.529 | 0.576 | 0.434 | 0.505 | 0.551 | 0.570 | |
| T/T | 0.251 | 0.221 | 0.192 | 0.232 | 0.275 | 0.178 | 0.234 |
UGT2B7 c_-161C>T allele frequencies in the Croatian population and data on worldwide populations (33, 34, 35, 36)
| NCBI dbSNP ID | Alleles | Croatian populationa | EURb | FINb | AFRb | EASb | SASc | AMRb | AJb | Otherb |
|---|---|---|---|---|---|---|---|---|---|---|
| UGT2B7 c.-161C>T rs7668258 | C | 0.4940 | 0.4624 | 0.5599 | 0.7078 | 0.7057 | 0.6010 | 0.6896 | 0.5625 | 0.5221 |
| T | 0.5060 | 0.5376 | 0.4401 | 0.2922 | 0.2943 | 0.3990 | 0.3104 | 0.4375 | 0.4779 |