Table 1
Body weight and relative brain and liver weight changes in mice treated with oral PFOA, CoQ10, and taurine
| Groups | Body weight change from baseline (%) | Relative brain weight (g/100 g) | Relative liver weight (g/100 g) |
|---|---|---|---|
| Control (water) | 3.03 (-6.43–8.14) | 1.25 (1.19–1.36) | 5.39 (5.00–5.82) |
| PFOA (15 mg/kg) | -11.76a (-14.71–8.33) | 1.50 (1.30–1.62) | 15.71d (14.67–15.91) |
| PFOA (30 mg/kg) | -21.21a (-28.57–0) | 1.51a (1.27–1.65) | 15.79d (15.00–17.44) |
| Taurine | -3.23 (-10.81–2.56) | 1.28 (1.18–1.45) | 5.09 (5.03–5.59) |
| Taurine + PFOA | -13.33 (-16.67–3.23) | 1.46 (1.32–1.54) | 16.00d,e (15.71–16.40) |
| Corn oil | -4.37 (-12.42–2.03) | 1.33 (1.19–1.48) | 5.47 (4.58–6.23) |
| CoQ10 | -7.89 (-8.33–0) | 1.30 (1.24–1.36) | 5.15 (5.15–5.37) |
| CoQ10 + PFOA | -17.65b,c (-22.86–9.38) | 1.37 (1.36–1.56) | 15.86f,g (13.09–17.04) |
Figure 1
Histopathological changes in mouse brain tissue stained with hematoxylin and eosin (200× magnification). A – control; B – PFOA dose of 15 mg/kg bw; C – PFOA dose of 30 mg/kg bw; D – taurine dose of 100 mg/kg bw; E – taurine+PFOA dose of 30 mg/kg bw; F – corn oil; G – CoQ10 dose of 50 mg/kg bw; H – CoQ10+PFOA dose of 30 mg/kg bw
Figure 2
Histopathological changes in mouse liver tissue stained with hematoxylin and eosin (200× magnification). A – control; B – PFOA dose of 15 mg/kg bw; C – PFOA dose of 30 mg/kg bw; D – taurine dose of 100 mg/kg bw; E – taurine+PFOA dose of 30 mg/kg bw; F – corn oil; G – CoQ10 dose of 50 mg/kg bw; H – CoQ10+PFOA dose of 30 mg/kg bw. Arrows: CV – central vein; H – hepatocellular hypertrophy; E – eosinophilic cytoplasm; B – balloon degeneration; FN – focal necrosis; N – necrosis; A – acidophilic cytoplasm
Figure 3
Total MDA and GSH levels in brain and liver tissues of mice treated with PFOA, taurine, and CoQ10 (data are expressed as medians and interquartile ranges, n=6 for water and corn oil groups; n=7 for treated groups). ap<0.01 and fp<0.05 relative to control; bp<0.01 and gp<0.05 relative to taurine; cp<0.01 relative to PFOA (30 mg/kg); dp<0.05 and hp<0.01 relative to corn oil; ep<0.05 and ip<0.01 relative to CoQ10
Figure 4
Antioxidant enzyme activity in brain and liver tissues of mice treated with PFOA, taurine, and CoQ10. (data are expressed as medians and interquartile ranges, n=6 for water and corn oil groups; n=7 for treated groups). ap<0.01 and gp<0.05 relative to PFOA (30 mg/kg); bp<0.01 and fp<0.05 relative to corn oil; cp<0.01 relative to CoQ10; dp<0.01 relative to control; ep<0.05 and hp<0.01 relative to taurine
Figure 5
Distribution of liver cells by cycle in mice treated with, PFOA, taurine, and CoQ10 (data are expressed as medians, n=3). ap<0.05 relative to the PFOA (30 mg/kg) group