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Perfluorooctanoic acid affects mouse brain and liver tissue through oxidative stress Cover

Perfluorooctanoic acid affects mouse brain and liver tissue through oxidative stress

Archives of Industrial Hygiene and Toxicology
Volume 73 (2022): Issue 2 (June 2022)
By: Burcu Ünlü Endirlik,  Ayşe Eken,  Hande Canpınar,  Figen Öztürk and  Aylin Gürbay  
Open Access
|Jul 2022

Figures & Tables

Figure 1

Histopathological changes in mouse brain tissue stained with hematoxylin and eosin (200× magnification). A – control; B – PFOA dose of 15 mg/kg bw; C – PFOA dose of 30 mg/kg bw; D – taurine dose of 100 mg/kg bw; E – taurine+PFOA dose of 30 mg/kg bw; F – corn oil; G – CoQ10 dose of 50 mg/kg bw; H – CoQ10+PFOA dose of 30 mg/kg bw
Histopathological changes in mouse brain tissue stained with hematoxylin and eosin (200× magnification). A – control; B – PFOA dose of 15 mg/kg bw; C – PFOA dose of 30 mg/kg bw; D – taurine dose of 100 mg/kg bw; E – taurine+PFOA dose of 30 mg/kg bw; F – corn oil; G – CoQ10 dose of 50 mg/kg bw; H – CoQ10+PFOA dose of 30 mg/kg bw

Figure 2

Histopathological changes in mouse liver tissue stained with hematoxylin and eosin (200× magnification). A – control; B – PFOA dose of 15 mg/kg bw; C – PFOA dose of 30 mg/kg bw; D – taurine dose of 100 mg/kg bw; E – taurine+PFOA dose of 30 mg/kg bw; F – corn oil; G – CoQ10 dose of 50 mg/kg bw; H – CoQ10+PFOA dose of 30 mg/kg bw. Arrows: CV – central vein; H – hepatocellular hypertrophy; E – eosinophilic cytoplasm; B – balloon degeneration; FN – focal necrosis; N – necrosis; A – acidophilic cytoplasm
Histopathological changes in mouse liver tissue stained with hematoxylin and eosin (200× magnification). A – control; B – PFOA dose of 15 mg/kg bw; C – PFOA dose of 30 mg/kg bw; D – taurine dose of 100 mg/kg bw; E – taurine+PFOA dose of 30 mg/kg bw; F – corn oil; G – CoQ10 dose of 50 mg/kg bw; H – CoQ10+PFOA dose of 30 mg/kg bw. Arrows: CV – central vein; H – hepatocellular hypertrophy; E – eosinophilic cytoplasm; B – balloon degeneration; FN – focal necrosis; N – necrosis; A – acidophilic cytoplasm

Figure 3

Total MDA and GSH levels in brain and liver tissues of mice treated with PFOA, taurine, and CoQ10 (data are expressed as medians and interquartile ranges, n=6 for water and corn oil groups; n=7 for treated groups). ap<0.01 and fp<0.05 relative to control; bp<0.01 and gp<0.05 relative to taurine; cp<0.01 relative to PFOA (30 mg/kg); dp<0.05 and hp<0.01 relative to corn oil; ep<0.05 and ip<0.01 relative to CoQ10
Total MDA and GSH levels in brain and liver tissues of mice treated with PFOA, taurine, and CoQ10 (data are expressed as medians and interquartile ranges, n=6 for water and corn oil groups; n=7 for treated groups). ap<0.01 and fp<0.05 relative to control; bp<0.01 and gp<0.05 relative to taurine; cp<0.01 relative to PFOA (30 mg/kg); dp<0.05 and hp<0.01 relative to corn oil; ep<0.05 and ip<0.01 relative to CoQ10

Figure 4

Antioxidant enzyme activity in brain and liver tissues of mice treated with PFOA, taurine, and CoQ10. (data are expressed as medians and interquartile ranges, n=6 for water and corn oil groups; n=7 for treated groups). ap<0.01 and gp<0.05 relative to PFOA (30 mg/kg); bp<0.01 and fp<0.05 relative to corn oil; cp<0.01 relative to CoQ10; dp<0.01 relative to control; ep<0.05 and hp<0.01 relative to taurine
Antioxidant enzyme activity in brain and liver tissues of mice treated with PFOA, taurine, and CoQ10. (data are expressed as medians and interquartile ranges, n=6 for water and corn oil groups; n=7 for treated groups). ap<0.01 and gp<0.05 relative to PFOA (30 mg/kg); bp<0.01 and fp<0.05 relative to corn oil; cp<0.01 relative to CoQ10; dp<0.01 relative to control; ep<0.05 and hp<0.01 relative to taurine

Figure 5

Distribution of liver cells by cycle in mice treated with, PFOA, taurine, and CoQ10 (data are expressed as medians, n=3). ap<0.05 relative to the PFOA (30 mg/kg) group
Distribution of liver cells by cycle in mice treated with, PFOA, taurine, and CoQ10 (data are expressed as medians, n=3). ap<0.05 relative to the PFOA (30 mg/kg) group

Body weight and relative brain and liver weight changes in mice treated with oral PFOA, CoQ10, and taurine

GroupsBody weight change from baseline (%)Relative brain weight (g/100 g)Relative liver weight (g/100 g)
Control (water)3.03 (-6.43–8.14)1.25 (1.19–1.36)5.39 (5.00–5.82)
PFOA (15 mg/kg)-11.76a (-14.71–8.33)1.50 (1.30–1.62)15.71d (14.67–15.91)
PFOA (30 mg/kg)-21.21a (-28.57–0)1.51a (1.27–1.65)15.79d (15.00–17.44)
Taurine-3.23 (-10.81–2.56)1.28 (1.18–1.45)5.09 (5.03–5.59)
Taurine + PFOA-13.33 (-16.67–3.23)1.46 (1.32–1.54)16.00d,e (15.71–16.40)
Corn oil-4.37 (-12.42–2.03)1.33 (1.19–1.48)5.47 (4.58–6.23)
CoQ10-7.89 (-8.33–0)1.30 (1.24–1.36)5.15 (5.15–5.37)
CoQ10 + PFOA-17.65b,c (-22.86–9.38)1.37 (1.36–1.56)15.86f,g (13.09–17.04)
DOI: https://doi.org/10.2478/aiht-2022-73-3629 | Journal eISSN: 1848-6312 | Journal ISSN: 0004-1254
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Language: English, Croatian, Slovenian
Page range: 148 - 157
Submitted on: Feb 1, 2022
Accepted on: Apr 1, 2022
Published on: Jul 7, 2022
Published by: Institute for Medical Research and Occupational Health
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
body weight,
CAT,
CoQ,
GPx,
GSH,
hepatotoxicity,
neurotoxicity,
oxidative damage,
PFOA,
relative organ weight,
SOD,
taurine
Related subjects:
Medicine,
Basic medical science,
Basic medical science, other

© 2022 Burcu Ünlü Endirlik, Ayşe Eken, Hande Canpınar, Figen Öztürk, Aylin Gürbay, published by Institute for Medical Research and Occupational Health
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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