Figure 1
Figure 2
Figure 3
Figure 4
Pharmacogenetic profile of our patient and related pharmacotherapy
| Gene-allele | Genotype | Phenotype | Drug-substrate | Drug-inhibitor |
|---|---|---|---|---|
| CYP2C9 *2, *3 | *1/*3 | diclofenac sulphamethoxazole trimethoprim | atorvastatin fenofibrate simvastatin sulphamethoxazole | |
| CYP2C19 *2, *17 | *1/*1 | normal metaboliser - NM | diclofenac pantoprazole propranolol | pantoprazole atorvastatin |
| CYP2D6 *3, *4, *5, *6, *41, xN | *1/*4 | propranolol | atorvastatin propranolol | |
| CYP3A4 *22 | *1/*1 | normal metaboliser - NM | atorvastatin diclofenac pantoprazole propranolol prednisone simvastatin | diclofenac pantoprazole |
| CYP3A5 *3 | *3/*3 | non-expresser | atorvastatin propranolol simvastatin | |
| UGT1A1 *28 | *1/*28 | atorvastatin furosemide simvastatin | atorvastatin pantoprazole | |
| UGT1A4 *2 (70C>A) | *1/*1 | normal enzyme activity | atorvastatin | |
| UGT1A4 *3 (142T>G) | *1/*3 | atorvastatin | fenofibrate | |
| UGT1A9 (-2152 C>T) | C/C | normal enzyme activity | fenofibrate atorvastatin | fenofibrate |
| UGT1A9 (-275 T>A ) | T/T | normal enzyme activity | fenofibrate atorvastatin | fenofibrate |
| UGT2B7 -161C>T | T/T | atorvastatin diclofenac propranolol simvastatin | fenofibrate | |
| ABCB1 (MDR1) 2677G>T/A ABCB1 (MDR1) 3435C>T | G/G T/T | atorvastatin pantoprazole prednisone propranolol simvastatin | atorvastatin ceftriaxone furosemide pantoprazole | |
| ABCC2 (MRP2) -24C>T ABCC2 (MRP2) 1249G>A | C/C G/G | normal transporter function | atorvastatin ceftriaxone diclofenac simvastatin | furosemide |
| ABCG2 421C>A | C/A | atorvastatin ceftriaxone diclofenac fenofibrate pantoprazole | furosemide pantoprazole | |
| SLCO1B1 *5 | *1A/*5 | atorvastatin diclofenac simvastatin | atorvastatin diclofenac fenofibrate |