Prevalence of five pharmacologically most important CYP2C9 and CYP2C19 allelic variants in the population from the Republic of Srpska in Bosnia and Herzegovina Cover

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Prevalence of five pharmacologically most important CYP2C9 and CYP2C19 allelic variants in the population from the Republic of Srpska in Bosnia and Herzegovina

Archives of Industrial Hygiene and Toxicology

Volume 72 (2021): Issue 2 (June 2021)

By: Stojko Vidović, Ranko Škrbić, Miloš P. Stojiljković, Vanja Vidović, Jelena Bećarević, Svjetlana Stoisavljević-Šatara and Nela Maksimović

Open Access

|Jun 2021

Figures & Tables

Genotype and predicted phenotype prevalences of the CYP2C19 allelic variants in the population of the Republic of Srpska

Genotype	Participants (N)	Prevalence (%)	Confidence interval (95 %)	Predicted phenotype
CYP2C191/1	89	41.20	34.57–48.08	normal metabolisers
CYP2C191/2	39	18.05	13.17–23.85	intermediate metabolisers
CYP2C192/17	13	6.02	3.24–10.07	intermediate metabolisers
CYP2C191/3	-	-	-	intermediate metabolisers
CYP2C193/17	-	-	-	intermediate metabolisers
CYP2C192/2	9	4.17	1.92–7.76	poor metabolisers
CYP2C193/3	-	-	-	poor metabolisers
CYP2C192/3	-	-	-	poor metabolisers
CYP2C191/17	57	26.39	20.64–32.80	rapid metabolisers
CYP2C1917/17	9	4.17	1.92–7.76	ultra-rapid metabolisers

Genotype and predicted phenotype prevalences of the CYP2C9 allelic variants in the population of the Republic of Srpska

Genotype	Participants (N)	Prevalence (%)	Confidence interval (95 %)	Predicted phenotype
CYP2C91/1	134	62.03	55.20–68.53	normal metabolisers
CYP2C91/2	47	21.76	16.45–27.86	intermediate metabolisers
CYP2C91/3	26	12.04	8.02–17.14	intermediate metabolisers
CYP2C92/2	5	2.31	0.76–5.32	intermediate metabolisers
CYP2C92/3	2	0.93	0.11–3.30	poor metabolisers
CYP2C93/3	2	0.93	0.11–3.30	poor metabolisers

Genotype and the prevalence of the CYP2C9 and CYP2C19 allelic variants in the population of the Republic of Srpska (RS) compared to other populations

												Alleles frequencies
Gene	Genotype	Genotype frequency n (%)	Alleles	RS	Bosnia and Herzegovina		Macedonia	Croatia		Serbia	Kosovo	Slovenia		Italy		Greece	Germany	Russia	Spain	Eastern Asians	African	African-American
	References				(36)	(37)	(17)	(8)	(38)	(25)	(30)	(26)	(39)	(40)	(41)	(24)	(20)	(22)	(23)	(16)	(29)	(29)
CYP2C92*	1/1	162 (75)	C	0.866	0.868	0.910	0.861	0.855	0.835	0.883	0.825	0.878	0.830	0.846	0.875	0.896	0.860	0.895	0.840	0.999	0.980	0.990
	1/2	46 (21.29)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
	2/2	5 (2.31)	T	0.134	0.132	0.090	0.139	0.145	0.165	0.117	0.175	0.122	0.170	0.154	0.125	0.104	0.140	0.105	0.160	0.0001	0.020	0.010
CYP2C93*	1/1	186 (86.11)	A	0.928	0.911	-	0.927	0.924	0.905	0.919	0.891	0.937	0.856	0.916	0.903	0.933	0.950	0.933	0.900	0.997	0.990	0.995
	1/3	28 (12.96)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
	3/3	2 (0.93)	c	0.072	0.089	-	0.073	0.076	0.095	0.081	0.109	0.063	0.144	0.084	0.097	0.067	0.050	0.067	0.100	0.003	0.010	0.005
CYP2C192*	1/1	155 (71.76)	G	0.847	-	0.830	0.856	0.852	0.850	0.837	0.870	0.841	-	0.907	0.889	0.869	-	0.886	-	-	-	-
	1/2	52 (24.07)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
	2/2	9 (4.17)	A	0.153	-	0.170	0.144	0.148	0.150	0.163	0.130	0.159	-	0.093	0.111	0.131	-	0.114	-	-	-	-
CYP2C193*	1/1	216 (100)	G	1.00	-	-	-	-	-	-	-	0.996	-	-	1.00	1.00	-	0.997	-	-	-	-
	1/3	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
	3/3	0	A	0.00	-	-	-	-	-	-	-	0.004	-	-	0.00	0.00	-	0.003	-	-	-	-
CYP2C1917*	1/1	137 (63.42)	C	0.796	-	-	0.799	0.763	-	0.778	0.810	-	-	0.776	-	-	-	-	-	-	-	-
	1/17	70 (32.41)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
	17/17	9 (4.17)	T	0.204	-	-	0.201	0.237	-	0.222	0.190	-	-	0.224	-	-	-	-	-	-	-	-

DOI: https://doi.org/10.2478/aiht-2021-72-3499 | Journal eISSN: 1848-6312 | Journal ISSN: 0004-1254

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Language: English, Croatian, Slovenian

Page range: 129 - 134

Submitted on: Oct 1, 2020

Accepted on: May 1, 2021

Published on: Jun 28, 2021

Published by: Institute for Medical Research and Occupational Health

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

cytochrome P450 enzymes,

pharmacogenetics,

polymorphic allele

Related subjects:

Basic medical science,

Basic medical science, other

© 2021 Stojko Vidović, Ranko Škrbić, Miloš P. Stojiljković, Vanja Vidović, Jelena Bećarević, Svjetlana Stoisavljević-Šatara, Nela Maksimović, published by Institute for Medical Research and Occupational Health
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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