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How improvements in monitoring and safety practices lowered airborne formaldehyde concentrations at an Italian university hospital: a summary of 20 years of experience Cover

How improvements in monitoring and safety practices lowered airborne formaldehyde concentrations at an Italian university hospital: a summary of 20 years of experience

Open Access
|Oct 2020

References

  1. Musiał A, Gryglewski RW, Kielczewski S, Loukas M, Wajda J. Formalin use in anatomical and histological science in the 19th and 20th centuries. Folia Med Cracov 2016;56:31–40. PMID: 28275269
  2. Dimenstein IB. A pragmatic approach to formalin safety in anatomical pathology. Lab Med 2009;40:740–6. doi: 10.1309/LMQ1HJFD4UN0WWBP
  3. Onyije FM, Avwioro OG. Excruciating effect of formaldehyde exposure to students in gross anatomy dissection laboratory. Int J Occup Environ Med 2012;3:92–5. PMID: 23022856
  4. Vimercati L, Carrus A, Martino T, Galise I, Minunni V, Caputo F, Dell’Erba A, Assennato G. Formaldehyde exposure and irritative effects on medical examiners, pathologic anatomy post-graduate students and technicians. Iran J Public Health 2010;39:26–34. PMCID: PMC3481685
  5. Flyvholm MA, Menné T. Allergic contact dermatitis from FA. A case study focusing on sources of formaldehyde exposure. Contact Derm 1992;27:27–36. doi: 10.1111/j.1600-0536.1992.tb05194.x
  6. Nielsen GD, Larsen ST, Wolkoff P. Re-evaluation of the WHO (2010) formaldehyde indoor air quality guideline for cancer risk assessment. Arch Toxicol 2017;91:35–61. doi: 10.1007/s00204-016-1733-8
  7. Friis UF, Dahlin J, Bruze M, Menné T, Johansen JD. Hidden exposure to formaldehyde in a swab caused allergic contact dermatitis. Contact Derm 2014;70:258–60. doi: 10.1111/cod.12172
  8. Dapson JC, Dapson RW. Hazardous Materials in the Histopathology Laboratory: Regulation, Risks, Handling and Disposal. 4th ed. Battle Creek: Anatech LTD; 2005.
  9. Council on Scientific Affairs, American Medical Association. Formaldehyde. JAMA 1989;261:1183–7.
  10. Chemical Industry Institute of Toxicology (CIIT). Formaldehyde: Hazard Characterization and Dose-Response Assessment for Carcinogenicity by the Route of Inhalation. Corrected and republished. Research Triangle Park (NC): CIIT; 1999.
  11. Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological Profile for Formaldehyde. Atlanta (GA): US Department of Health and Human Services; 1999.
  12. Hazardous Substances Data Bank (HSDB, online database) US National Library of Medicine, National Toxicology Information Program, Bethesda, MD, 1999 March.
  13. Viegas S, Ladeira C, Costa-Veiga A, Perelman J, Gajski G. Forgotten public health impacts of cancer - an overview. Arh Hig Rada Toksikol 2017;68:287–97. doi: 10.1515/aiht-2017-68-3005
  14. International Agency for Research on Cancer (IARC). IARC Classifies Formaldehyde as Carcinogenic to Humans [displayed 27 December 2019]. Available at http://www.iarc.fr/pageroot/PRELEASES/pr153a.html
  15. International Agency for Research on Cancer (IARC). Formaldehyde, 2-Butoxyethanol and 1-tert-Butoxypropan-2-ol. Monographs on the Evaluation Carcinogenic Risks on Humans. Vol. 88, 2006 [displayed 11 August 2020]. Available at https://publications.iarc.fr/Book-And-Report-Series/Iarc-Monographs-On-The-Identification-Of-Carcinogenic-Hazards-To-Humans/Formaldehyde-2-Butoxyethanol-And-1-Em-Tert-Em-Butoxypropan-2-ol-2006
  16. International Agency for Research on Cancer (IARC). Chemical agents and related occupations volume 100 F A review of human carcinogens; 2012 [displayed 28 August 2020]. Available at https://publications.iarc.fr/Book-And-Report-Series/Iarc-Monographs-On-The-Identification-Of-Carcinogenic-Hazards-To-Humans/Chemical-Agents-And-Related-Occupations-2012
  17. Szarvas T, Szatloczky E, Volford J, Trezl L, Tyihak E, Rusznak I. Determination of endogenous formaldehyde level in human blood and urine by dimedone-14C radiometric method. J Radioanal Nucl Chem 1986;106:357–67. doi: 10.1007/BF02163668
  18. Heck HD, Casanova-Shmitz M, Dodd PB, Schachter EN, Witec TJ, Tosun T. Formaldehyde (CH2O) concentration in the blood of humans and Ficher-344 rats exposed to CH2O under controlled conditions. Am Ind Hyg Assoc J 1985;46:1–3. doi: 10.1080/15298668591394275
  19. Spanel P, Smith D, Holland TA, Al Singary W, Elder JB. Analysis of formaldehyde in the headspace of urine from bladder and prostate cancer patients using selected ion flow tube mass spectrometry. Rapid Commun Mass Spectrom 1999;13:1354–9. doi: 10.1002/(SICI)1097-0231(19990730)13:14<;1354::AID-RCM641>3.0.CO;2-J
  20. Dugheri S, Bonari A, Pompilio I, Colpo M, Mucci N, Arcangeli G. An integrated air monitoring approach for assessment of formaldehyde in the workplace. Saf Health Work 2018;9:479–485. doi: 10.1016/j.shaw.2018.05.002
  21. Scarselli A, Corfiati M, Di Marzio D, Iavicoli S. National estimates of exposure to formaldehyde in Italian workplaces. Ann Work Expo Health 2017;61:33–43. doi: 10.1093/annweh/wxw004
  22. American Chemistry Council’s (ACC). ACGIH decision to lower formaldehyde TLVs lacks transparency and scientific basis [displayed 20 December 2020]. Available at https://www.americanchemistry.com/Media/PressReleasesTranscripts/ACC-news-releases/ACGIH-Decision-to-Lower-Formaldehyde-TLVs-Lacks-Transparency-and-Scientific-Basis.html
  23. Directive (EU) 2019/983 of the European Parliament and of the Council of 5 June 2019 amending Directive 2004/37/EC on the protection of workers from the risks related to exposure to carcinogens or mutagens at work [displayed 28 August 2020]. Available at https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=uriserv:OJ.L_.2019.164.01.0023.01.ENG
  24. Szulejko JE, Kim KH. Derivatization techniques for determination of carbonyls in air. TrAC Trends Anal Chem 2015;64:29–41. doi: 10.1016/j.trac.2014.08.010
  25. Dugheri S, Bonari A, Pompilio I, Colpo M, Mucci N, Montalti M, Arcangeli G. Development of an innovative gas chromatography-mass spectrometry method for assessment of formaldehyde in the workplace atmosphere. Acta Chromatogr 2017;29:511–4. doi: 10.1556/1326.2016.00102
  26. Mucci N, Dugheri S, Rapisarda V, Campagna M, Garzaro G, Farioli A, Cappelli G, Arcangeli G. Occupational exposure to airborne formaldehyde in hospital: setting an automatic sampling system, comparing different monitoring methods and applying them to assess exposure. Med Lav 2019;110:446–58. doi: 10.23749/mdl.v110i6.8038
  27. Dugheri S, Mucci N, Cappelli G, Bonari A, Garzaro G, Marrubini G, Bartolucci G, Campagna M, Arcangeli G. Monitoring of air-dispersed formaldehyde and carbonyl compounds as vapors and adsorbed on particulate matter by denuder-filter sampling and gas chromatographic analysis. Int J Environ Res Public Health 2019;16:1969. doi: 10.3390/ijerph16111969
  28. Čavlović AO, Lučić RB, Jug M, Radmanović K, Bešlić I. Side-by-side determination of workers’ exposure to wood dust with IOM and openfaced samplers. Arh Hig Rada Toksikol 2013;64:379–84. doi: 10.2478/10004-1254-64-2013-2316
  29. Carrier D. Analysis of Formaldehyde and Acetaldehyde using automated DNPH derivatisation. Chromatography Technical Note No AS109 [displayed 11 August 2020]. Available at https://www.anatune.co.uk/wp-content/uploads/2015/06/as109.pdf
  30. Dalene M, Persson P, Skarping G. Determination of formaldehyde in air by chemisorption on glass filters impregnated with 2,4-dinitrophenylhydrazine using gas chromatography with thermionic specific detection. J Chromatogr A 1992;626:284–8. doi: 10.1016/0021-9673(92)85422-P
  31. Martos PA, Pawliszyn J. Sampling and determination of formaldehyde using solid-phase microextraction with on-fiber derivatization. Anal Chem 1998;70:2311–20. doi: 10.1021/ac9711394
  32. Bourdin D, Desauziers V. Development of SPME on-fiber derivatization for the sampling of formaldehyde and other carbonyl compounds in indoor air. Anal Bioanal Chem 2014;406:317–28. doi: 10.1007/s00216-013-7460-6
  33. Associazione per l’Unificazione nel Settore dell’Industria Chimica (Unichim). [Metodo Ufficiale n. 2237:09: Ambienti di Lavoro-Determinazione delle aldeidi aerodisperse. Metodo per microestrazione in fase solida (SPME), in Italian]. In: Analisi mediante gascromatografia accoppiata alla spettrometria di massa (GC-MS), 2009.
  34. Dugheri S, Mucci N, Pompilio I, Cappelli G, Bossi C, Bonari A, Arcangeli G. Determination of airborne formaldehyde and ten other carbonyl pollutants using programmed temperature vaporization-large volume injection-gas chromatography. Chinese J Chrom 2018;36:1311–22. doi: 10.3724/SP.J.1123.2018.08050
  35. UNI - Ente Italiano di Normazione. UNI/TS 11710:2018 -Fume cupboards for chemical handling – Limit values for containment, face velocity and air exchange efficiency; 2018 [displayed 28 August 2020]. Available at http://store.uni.com/catalogo/uni-ts-11710-2018?___store=en&josso_back_to=http%3A%2F%2Fstore.uni.com%2Fjosso-security-check.php&josso_cmd=login_optional&josso_partnerapp_host=store.uni.com&___from_store=it
  36. Ministry of Health, Higher Health Council, Italy. Section I. Guidelines tracking, collection, transport, preservation and storage of cells and tissues for diagnostic investigations of pathological anatomy; 2016 [displayed 11 August 2019]. Available at http://www.salute.gov.it/imgs/C_17_pubblicazioni_2504_allegato.pdf
  37. Fiocca R, Marchetti A, Massi D, Truini M, Zanin T. [Note relative all’utilizzo della formalina, ri-classificata “cancerogena”, in Italian]. Linee di indirizzo SIAPEC-IAP Divisione Italiana 2016
  38. UNI - Ente Italiano di Normazione. UNI EN 689:2018 – Workplace exposure – Measurement of exposure by inhalation to chemical agents - Strategy for testing compliance with occupational exposure limit values; 2018 [displayed 28 August 2020]. Available at http://store.uni.com/catalogo/uni-en-689-2018?___store=en&josso_back_to=http%3A%2F%2Fstore.uni.com%2Fjosso-security-check.php&josso_cmd=login_optional&josso_partnerapp_host=store.uni.com&___from_store=it
  39. Ochs SD M, Grotz LD O, Factorine LS, Rodrigues MR, Netto AD P. Occupational exposure to formaldehyde in an institute of morphology in Brazil: a comparison of area and personal sampling. Environ Sci Pollut Res Int 2011;19:2813–9. doi: 10.1007/s11356-012-0786-3
  40. Costa S, Coelho P, Costa C, Silva S, Mayana O, Santos LS, Gaspar J, Teixeira JP. Genotoxic damage in pathology anatomy laboratory workers exposed to formaldehyde. Toxicology 2008;252:40–8. doi: 10.1016/j.tox.2008.07.056
  41. Orsière T, Sari-Minodier I, Iarmarcovai G, Botta A. Genotoxic risk assessment of pathology and anatomy laboratory workers exposed to formaldehyde by use of personal air sampling and analysis of DNA damage in peripheral lymphocytes. Mutat Res Genet Toxicol Environ Mutagen 2006;605:30–41. doi: 10.1016/j.mrgentox.2006.01.006
DOI: https://doi.org/10.2478/aiht-2020-71-3406 | Journal eISSN: 1848-6312 | Journal ISSN: 0004-1254
Language: English, Croatian, Slovenian
Page range: 178 - 189
Submitted on: Mar 1, 2020
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Accepted on: Aug 1, 2020
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Published on: Oct 6, 2020
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2020 Stefano Dugheri, Daniela Massi, Nicola Mucci, Nicola Berti, Giovanni Cappelli, Giulio Arcangeli, published by Institute for Medical Research and Occupational Health
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.