Figure 1
Figure 2
Figure 3
Average FIB-4 index, methadone-to-EDDP urine concentration ratio, and methadone dose received by study groups (N=35)
| Parameters | HCV-negative (n=12) | HCV-positive (n=16) | HCV clinical remission (n=7) |
|---|---|---|---|
| FIB-4 index | 0.81 | 2.61 | 2.08 |
| Methadone-to-EDDP urine concentration ratio | 0.87 | 2.04 | 0.79 |
| Methadone dose (mg) | 83.2 | 85.0 | 62.5 |
Genotype and allele frequencies (%) by loci for the ABCB1, CYP2B6 and CYP3A4 genes in all participants (N=35)
| Gene | SNP | Genotype | n (%) | Minor allele | MAF (%) | Hardy-Weinberg equilibrium | |
|---|---|---|---|---|---|---|---|
| p allele frequency | χ2 p-value | ||||||
| GG | 12 (34.3) | ||||||
| ABCB1 | rs1045642 | AG | 16 (45.7) | A | 42.9 | 0.57 | 0.15 0.69 |
| AA | 7 (20) | ||||||
| GG | 15 (42.9) | ||||||
| CYP2B6 | rs3745274 | GT | 17 (48.5) | T | 32.9 | 0.67 | 0.36 0.55 |
| TT | 3 (8.6) | ||||||
| CC | 30 (85.7) | ||||||
| CYP3A4 | rs2242480 | CT | 5 (14.3) | T | 7.1 | 0.93 | 0.21 0.65 |
| TT | 0 (0) | ||||||
| TT | 34 (97.1) | ||||||
| CYP3A4 | rs2740574 | CT | 1 (2.9) | C | 1.4 | 0.99 | 0.007 0.93 |
| CC | 0 (0) | ||||||