Have a personal or library account? Click to login
The association between the OPRM1 A118G polymorphism and addiction in a Turkish population Cover

The association between the OPRM1 A118G polymorphism and addiction in a Turkish population

Open Access
|Jun 2019

References

  1. 1. Koob GF, Volkow ND. Neurocircuitry of addiction. Neuropsychopharmacology 2010;35:217–38. doi: 10.1038/npp.2009.11010.1038/npp.2009.110
  2. 2. Haile CN, Kosten TA, Kosten TR. Pharmacogenetic treatments for substance addiction: alcohol and opiates. Am J Drug Alcohol Abuse 2008;34:355–81. doi: 10.1080/0095299080212256410.1080/00952990802122564
  3. 3. Bond C, LaForge KS, Tian M, Melia D, Zhang S, Borg L, Gong J, Schluger J, Strong JA, Leal SM, Tischfield JA, Kreek MJ, Yu L. Single-nucleotide polymorphism in the human mu opioid receptor gene alters β-endorphin binding and activity: Possible implications for opiate addiction. Proc Natl Acad Sci USA 1998;95:9608–13.10.1073/pnas.95.16.9608
  4. 4. Crist RC, Berrettini WH. Pharmacogenetics of OPRM1. Pharmacol Biochem Behav 2014;123:25–33. doi: 10.1016/j.pbb.2013.10.01810.1016/j.pbb.2013.10.018
  5. 5. Beyer A, Koch T, Schröder H, Schulz S, Höllt V. Effect of the A118G polymorphism on binding affinity, potency and agonist-mediated endocytosis, desensitization, and resensitization of the human mu-opioid receptor. J Neurochem 2004; 89: 553 – 60. doi: 10.1111/j.1471-4159.2004.02340.x10.1111/j.1471-4159.2004.02340.x
  6. 6. Bart G, Kreek MJ, Ott J, LaForge KS, Proudnikov D, Pollak L, Heilig M. Increased attributable risk related to a functional mu-opioid receptor gene polymorphism in association with alcohol addiction in central Sweden. Neuropsychopharmacology 2005;30:417–22. doi: 10.1038/sj.npp.130059810.1038/sj.npp.1300598
  7. 7. Kim SA, Kim JW, Song JY, Park S, Lee HJ, Chung JH. Association of polymorphisms in nicotinic acetylcholine receptor alpha 4 subunit gene (CHRNA4), mu-opioid receptor gene (OPRM1), and ethanol-metabolizing enzyme genes with alcoholism in Korean patients. Alcohol 2004;34:115–20. PMID: 1590290410.1016/j.alcohol.2004.06.004
  8. 8. Loh W, Fann CS, Chang YT, Chang CJ, Cheng AT. Endogenous opioid receptor genes and alcohol addiction among Taiwanese Han. Alcohol Clin Exp Res 2004;28:15–9. doi: 10.1097/01.ALC.0000106303.41755.B810.1097/01.ALC.0000106303.41755.B8
  9. 9. Bergen AW, Kokoszka J, Peterson R, Long JC, Virkkunen M, Linnoila M, Goldman D. Mu opioid receptor gene variants: lack of association with alcohol addiction. Mol Psychiatry 1997;2:490–4. doi: 10.1038/sj.mp.400033110.1038/sj.mp.4000331
  10. 10. Luo X, Kranzler HR, Zhao H, Gelernter J. Haplotypes at the OPRM1 locus are associated with susceptibility to substance addiction in European-Americans. Am J Med Gent B Neuropsychiatr Genet 2003;120:97–108. doi: 10.1002/ajmg.b.2003410.1002/ajmg.b.20034
  11. 11. Troisi A, Frazzetto G, Carola V, Di Lorenzo G, Coviello M, D’Amato FR, Moles A, Siracusano A, Gross C. Social hedonic capacity is associated with the A118G polymorphism of the mu-opioid receptor gene (OPRM1) in adult healthy volunteers and psychiatric patients. Soc Neurosci 2011;6:88–97. doi: 10.1080/17470919.2010.48278610.1080/17470919.2010.482786
  12. 12. Ding S, Chen B, Zheng Y, Lu Q, Liu L, Zhuge Q. Association study of OPRM1 polymorphisms with Schizophrenia in Han Chinese population. BMC Psychiatry 2013;13:107. doi: 10.1186/1471-244X-13-10710.1186/1471-244X-13-107
  13. 13. Serý O, Prikryl R, Castulík L, St’astný F. A118G polymorphism of OPRM1 gene is associated with schizophrenia. J Mol Neurosci 2010;41:219–22.10.1007/s12031-010-9327-z
  14. 14. The American Psychiatric Association (APA). Diagnostic and Statistical Manual of Mental Disorders. 5th ed. Washington (DC): American Psychiatric Publishing; 2013.10.1176/appi.books.9780890425596
  15. 15. Karahalil B, Kocabaş NA. hOGG1 SER326CYS genetic polymorphism in a Turkish population. Arch Toxicol 2005;79:377–80. doi: 10.1007/s00204-005-0665-510.1007/s00204-005-0665-5
  16. 16. Yuferov V, Levran O, Proudnikov D, Nielsen DA, Kreek MJ. Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment. Ann N Y Acad Sci 2010;1187:184–207. doi: 10.1111/j.1749-6632.2009.05275.x10.1111/j.1749-6632.2009.05275.x
  17. 17. Kapur S, Sharad S, Sıngha RA. A118g polymorphism in mu opioid receptor gene (OPRM1): association with opiate addiction in subjects of Indian origin. J Integr Neurosci 2007;6:511–22. doi: 10.1142/S021963520700163510.1142/S0219635207001635
  18. 18. Zhang D, Shao C, Shao M, Yan P, Wang Y, Liu Y, Liu W, Lin T, Xie Y, Zhao Y, Lu D, Li Y, Jin L. Effect of μ-opioid receptor gene polymorphisms on heroin-induced subjective responses in a Chinese population. Biol Psychiatry 2007;61:1244–51. doi: 10.1016/j.biopsych.2006.07.01210.1016/j.biopsych.2006.07.012
  19. 19. Deb I, Chakraborty J, Gangopadhyay PK, Choudhury SR, Das S. Single-nucleotide polymorphism (A118G) in exon 1 of OPRM1 gene causes alteration in downstream signaling by mu-opioid receptor and may contribute to the genetic risk for addiction. J Neurochem 2010;112:486–96. doi: 10.1111/j.1471-4159.2009.06472.x10.1111/j.1471-4159.2009.06472.x
  20. 20. Sander T, Gscheidel N, Wendel B, Samochowiec J, Smolka M, Rommelspacher H, Schmidt LG, Hoehe MR. Human µ-opioid receptor variation and alcohol addiction. Alcohol Clin Exp Res 1998;22:2108–10. doi: 10.1111/j.1530-0277.1998.tb05923.x10.1111/j.1530-0277.1998.tb05923.x
  21. 21. Crowley JJ, Oslin DW, Patkar AA, Gottheil E, DeMaria PA Jr, O’Brien CP, Berrettini WH, Grice DE. A genetic association study of the mu opioid receptor and severe opioid dependence. Psychiatr Genet 2003;13:169–73. PMID: 1296074910.1097/00041444-200309000-00006
  22. 22. Nikolov MA, Beltcheva O, Galabova A, Ljubenova A, Jankova E, Gergov G, Russev AA, Lynskey MT, Nelson EC, Nesheva E, Krasteva D, Lazarov P, Mitev VI, Kremensky IM, Kaneva RP, Todorov AA. No evidence of association between 118A>G OPRM1 polymorphism and heroin addiction in a large Bulgarian case-control sample. Drug Alcohol Depend 2011;117:62–5. doi: 10.1016/j.drugalcdep.2010.12.02610.1016/j.drugalcdep.2010.12.026
  23. 23. Klepstad P, Rakvag TT, Kaasa S, Holthe M, Dale O, Borcgrevink PC, Baar C, Vikan T, Krokan HE, Skorpen F. The 118AG polymorphism in the human µ-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease. Acta Anaesthesiol Scand 2004;48:1232–9. doi: 10.1111/j.1399-6576.2004.00517.x10.1111/j.1399-6576.2004.00517.x
  24. 24. Gelernter J, Kranzler H, Cubells J. Genetics of two m opioid receptor gene (OPRM1) exon I polymorphisms: population studies, and allele frequencies in alcohol- and substance-dependent subjects. Mol Psychiatry 1999;4:476–83. doi: 10.1038/sj.mp.400055610.1038/sj.mp.4000556
  25. 25. Daher M, Costa FMM, Neves FAR. Genotyping the muopioid Receptor A118G polymorphism using the real-time amplification refractory mutation system: allele frequency distribution among Brazilians. Pain Pract 2013;13:614–20. doi: 10.1111/papr.1204210.1111/papr.12042
  26. 26. Ahmed M, Ul Haq I, Faisal M, Waseem D, Mumtaz MT. Implication of OPRM1 A118G polymorphism in opioids addicts in Pakistan: in vitro and in silico analysis. J Mol Neurosci 2018;65:472–9. doi: 10.1007/s12031-018-1123-110.1007/s12031-018-1123-1
  27. 27. Szeto CY, Tang NL, Lee DT, Stadlin A. Association between mu opioid receptor gene polymorphisms and Chinese heroin addicts. Neuroreport 2001;12:1103–6. doi: 10.1097/00001756-200105080-0001110.1097/00001756-200105080-00011
  28. 28. Nagaya D, Ramanathan S, Ravichandran M, Navaratnam V. A118G mu opioid receptor polymorphism among drug addicts in Malaysia. J Integr Neurosci 2012;11:117–22. doi: 10.1142/S021963521250008210.1142/S0219635212500082
  29. 29. Kim SG, Kim CM, Kang DH, Kim YJ, Byun WT, Kim SY, Park JM, Kim MJ, Oslin DW. Association of functional opioid receptor genotypes with alcohol addiction in Koreans. Alcohol Clin Exp Res 2004;28:986–90. doi: 10.1097/01.ALC.0000130803.62768.AB10.1097/01.ALC.0000130803.62768.AB
  30. 30. Franke P, Wang T, Nothen MM, Knapp M, Neidt H, Albrecht S, Jahnes E, Propping P, Maier W. Nonreplication of association between mu-opioid-receptor gene (OPRM1) A118G polymorphism and substance addiction. Am J Med Genet 2001;105:114–9. PMID: 1142498110.1002/1096-8628(20010108)105:1<;114::AID-AJMG1074>3.0.CO;2-L
  31. 31. Ide S, Kobayashi H, Tanaka K, Ujike H, Sekine Y, Ozaki N, Inada T, Harano M, Komiyama T, Yamada M, Iyo M, Ikeda K, Sora I. Gene polymorphisms of the mu opioid receptor in methamphetamine abusers. Ann N Y Acad Sci 2004;1025:316–24. doi: 10.1196/annals.1316.03910.1196/annals.1316.039
  32. 32. Ginosar Y, Davidson EM, Meroz Y, Blotnick S, Shacham M, Caraco Y. Mu-opioid receptor (A118G) single-nucleotide polymorphism affects alfentanil requirements for extracorporeal shock wave lithotripsy: a pharmacokinetic – pharmacodynamic study. Br J Anaesth 2009;103:420–7. doi: 10.1093/bja/aep19210.1093/bja/aep192
  33. 33. Kumar D, Chakraborty J, Das S. Epistatic effects between variants of kappa-opioid receptor gene and A118G of muopioid receptor gene increase susceptibility to addiction in Indian population. Prog Neuropsychopharmacol Biol Psychiatry 2012;36:225–30. doi: 10.1016/j.pnpbp.2011.10.01810.1016/j.pnpbp.2011.10.018
  34. 34. Arias A, Feinn R, Kranzler R. Association of an Asn40Asp (A118G) polymorphism in the µ-opioid receptor gene with substance addiction: A meta-analysis. Drug Alcohol Depend 2006;27:262–8. doi: 10.1016/j.drugalcdep.2005.11.02410.1016/j.drugalcdep.2005.11.024
  35. 35. Chen D, Liu L, Xiao Y, Peng Y, Yang C, Wang Z. Ethnic-specific meta-analyses of association between the OPRM1 A118G polymorphism and alcohol addiction among Asians and Caucasians. Drug Alcohol Depend 2012;123:1–6. doi: 10.1016/j.drugalcdep.2011.10.01210.1016/j.drugalcdep.2011.10.012
  36. 36. Tan EC, Tan CH, Karupathivan U, Yap EP. Mu opioid receptor gene polymorphisms and heroin addiction in Asian populations. Neuroreport 2004;14:569–72. PMID: 1265788710.1097/00001756-200303240-00008
  37. 37. Hoehe MR, Köpke K, Wendel B, Rohde K, Flachmeier C, Kidd KK, Berrettini WH, Church GM. Sequence variability and candidate gene analysis in complex disease: association of µ opioid receptor gene variation with substance dependence. Hum Mol Genet 2000;9:2895–908. doi: 10.1093/hmg/9.19.289510.1093/hmg/9.19.2895
DOI: https://doi.org/10.2478/aiht-2019-70-3153 | Journal eISSN: 1848-6312 | Journal ISSN: 0004-1254
Language: English, Croatian, Slovenian
Page range: 97 - 103
Submitted on: May 1, 2018
Accepted on: Apr 1, 2019
Published on: Jun 26, 2019
Published by: Institute for Medical Research and Occupational Health
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2019 Hülya Türkan, Bensu Karahalil, Ela Kadıoğlu, Kenan Eren, Defne Tamar Gürol, Ali Esat Karakaya, published by Institute for Medical Research and Occupational Health
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.