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Circumventing vascular barriers for effective immunotherapy in brain tumors – focus on glioblastoma Cover

Circumventing vascular barriers for effective immunotherapy in brain tumors – focus on glioblastoma

Postępy Higieny i Medycyny Doświadczalnej
Volume 79 (2025): Issue 1 (January 2025)
By: Janusz Rak  
Open Access
|Aug 2025

Figures & Tables

Figure 1.

Targeting the immune-vascular interface in glioblastoma. The combined effect of blood-brain barrier (BBB), blood-tumor barrier (BTB), and endothelial anergy contributes to the exclusion of immune cells (T, NK) from the brain tumor microenvironment. Overcoming this scarcity by intracranial delivery of immune cells, modulating vascular wall (para-endothelial gaps), coupled with tumor debulking (to reduce the size of the target cell population) and targeting immunosuppressive mechanisms may collectively improve outcomes of immunotherapy in glioblastoma and other brain tumors (see text)
Targeting the immune-vascular interface in glioblastoma. The combined effect of blood-brain barrier (BBB), blood-tumor barrier (BTB), and endothelial anergy contributes to the exclusion of immune cells (T, NK) from the brain tumor microenvironment. Overcoming this scarcity by intracranial delivery of immune cells, modulating vascular wall (para-endothelial gaps), coupled with tumor debulking (to reduce the size of the target cell population) and targeting immunosuppressive mechanisms may collectively improve outcomes of immunotherapy in glioblastoma and other brain tumors (see text)
DOI: https://doi.org/10.2478/ahem-2025-0012 | Journal eISSN: 1732-2693
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Language: English
Page range: 95 - 105
Submitted on: Apr 15, 2025
|
Accepted on: May 20, 2025
|
Published on: Aug 6, 2025
Published by: Hirszfeld Institute of Immunology and Experimental Therapy
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year
Keywords:
angiogenesis,
glioblastoma,
cancer,
tumour vasculature,
immunotherapy,
NK cells,
blood brain barrier,
extracellular vesicles,
vasectasia,
Rab27
Related subjects:
Life sciences,
Molecular biology,
Microbiology and virology,
Medicine,
Basic medical science,
Immunology

© 2025 Janusz Rak, published by Hirszfeld Institute of Immunology and Experimental Therapy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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