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Can the HALP score predict survival in severe COVID-19 pneumonia?

Open Access
|Dec 2023

References

  1. Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, Wang B, Xiang H, Cheng Z, Xiong Y et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020; 323: 1061–1069.
  2. Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, Si HR, Zhu Y, Li B, Huang CL et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020; 579: 270–273.
  3. Jiang F, Deng L, Zhang L, Cai Y, Cheung CW, Xia Z. Review of the Clinical Characteristics of Coronavirus Disease 2019 (COVID-19). J Gen Intern Med. 2020; 35: 1545–1549.
  4. https://data.who.int/dashboards/covid19/deaths?n=c (Accessed December 2022)
  5. Zhou M, Zhang X, Qu J. Coronavirus disease 2019 (COVID-19): a clinical update. Front Med. 2020; 14: 126–135.
  6. Varghese GM, John R, Manesh A, Karthik R, Abraham OC. Clinical management of COVID-19. Indian J Med Res. 2020; 151:401–410.
  7. Oliveira E, Parikh A, Lopez-Ruiz A, Carrilo M, Goldberg J, Cearras M, Fernainy K, Andersen S, Mercado L, Guan J et al. ICU outcomes and survival in patients with severe COVID-19 in the largest health care system in central Florida. PLoS One. 2021; 16: e0249038.
  8. Panigrahy D, Gilligan MM, Huang S, Gartung A, Cortés-Puch I, Sime PJ, Phipps RP, Serhan CN, Hammock BD. Inflammation resolution: a dual-pronged approach to averting cytokine storms in COVID-19? Cancer Metastasis Rev. 2020; 39: 337–340.
  9. Gong J, Dong H, Xia QS, Huang ZY, Wang DK, Zhao Y, Liu WH, Tu SH, Zhang MM, Wang Q, Lu FE. Correlation analysis between disease severity and inflammation-related parameters in patients with COVID-19: a retrospective study. BMC Infect Dis. 2020; 20: 963.
  10. Richardson S, Hirsch JS, Narasimhan M, Crawford JM, McGinn T, Davidson KW. Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area. JAMA. 2020; 323: 2052–2059.
  11. Tian M, Li Y, Wang X, Tian X, Pei LL, Wang X, Zhang L, Sun W, Wu J, Sun S et al. The Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score is Associated With Poor Outcome of Acute Ischemic Stroke. Front Neurol. 2021; 11: 610318.
  12. Zhai B, Chen J, Wu J, Yang L, Guo X, Shao J, Xu H, Shen A. Predictive value of the hemoglobin, albumin, lymphocyte, and platelet (HALP) score and lymphocyte-to-monocyte ratio (LMR) in patients with non-small cell lung cancer after radical lung cancer surgery. Ann Transl Med. 2021; 9: 976.
  13. T.C. Sağlık Bakanlığı. Turkey Country Assessment. https://covid19.saglik.gov.tr/Eklenti/39551/0/covid-19rehberigenelbilgilerepidemiyolojivetanipdf.pdf
  14. T.C. Sağlık Bakanlığı. Turkey Country Assessment. https://covid19.saglik.gov.tr/Eklenti/43095/0/covid-19rehberieriskinhastayonetimivetedavi-12042022pdf.pdf
  15. World Health Organization. WHO Coronavirus (COVID-19) Dashboard. https://covid19.who.int (accessed July 24, 2022)
  16. Docherty AB, Harrison EM, Green CA, Hardwick HE, Pius R, Norman L, Holden KA, Read JM, Dondelinger F, Carson G et al. Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study. Br Med J. 2020; 369:m1985.
  17. Kenny G, Mallon PW. COVID-19 clinical presentation and therapeutic considerations. Biochem Biophys Res Commun. 2021; 538: 125–131.
  18. Liu S, Yao N, Qiu Y, He C. Predictive performance of SOFA and qSOFA for in-hospital mortality in severe novel coronavirus disease. Am J Emerg Med. 2020; 38: 2074–2080.
  19. Kukoč A, Mihelčić A, Miko I, Romić A, Pražetina M, Tipura D, Drmić Ž, Čučković M, Ćurčić M, Blagaj V et al. Clinical and laboratory predictors at ICU admission affecting course of illness and mortality rates in a tertiary COVID-19 center. Heart Lung. 2022; 53: 1–10.
  20. Gallo Marin B, Aghagoli G, Lavine K, Yang L, Siff EJ, Chiang SS, Salazar-Mather TP, Dumenco L, Savaria MC, Aung SN et al. Predictors of COVID-19 severity: a literature review. Rev Med Virol. 2021; 31: e2146.
  21. Figliozzi S, Masci PG, Ahmadi N, Tondi L, Koutli E, Aimo A, Stamatelopoulos K, Dimopoulos MA, Caforio ALP, Georgiopoulos G. Predictors of adverse prognosis in COVID-19: a systematic review and meta-analysis. Eur J Clin Invest. 2020; 50: e13362.
  22. Ciceri F, Castagna A, Rovere-Querini P, De Cobelli F, Ruggeri A, Galli L, Conte C, De Lorenzo R, Poli A, Ambrosio A et al. Early predictors of clinical outcomes of COVID-19 outbreak in Milan, Italy. Clin Immunol. 2020: 217: 108509.
  23. Beigmohammadi MT, Amoozadeh L, Rezaei Motlagh F, Rahimi M, Maghsoudloo M, Jafarnejad B, Eslami B, Salehi MR, Zendehdel K. Mortality Predictive Value of APACHE II and SOFA Scores in COVID-19 Patients in the Intensive Care Unit. Can Respir J. 2022: 5129314.p.8.
  24. Umeh C, Tuscher L, Ranchithan S, Watanabe K, Gupta R. Predictors of COVID-19 Mortality in Critically Ill ICU Patients: A Multicenter Retrospective Observational Study. Cureus. 2022; 14: e20952.
  25. Connors JM, Levy JH. COVID-19 and its implications for thrombosis and anticoagulation. Blood. 2020; 135: 2033–2040.
  26. Li L, Zhang S, He B, Chen X, Wang S, Zhao Q. Risk factors and electrocardiogram characteristics for mortality in critical inpatients with COVID-19. Clin Cardiol. 2020; 43: 1624–1630.
  27. Martinot M, Eyriey M, Gravier S, Bonijoly T, Kayser D, Ion C, Mohseni-Zadeh M, Camara S, Dubois J, Haerrel E et al. Predictors of mortality, ICU hospitalization, and extrapulmonary complications in COVID-19 patients. Infect Dis Now. 2021; 51: 518–525.
  28. Han Y, Zhang H, Mu S, Wei W, Jin C, Tong C, Song Z, Zha Y, Xue Y, Gu G. Lactate dehydrogenase, a risk factor of severe COVID-19 patients: A Retrospective and Observational Study. Aging (Albany NY). 2020; 12: 11245–11258.
  29. Kuang ZS, Yang YL, Wei W, Wang JL, Long XY, Li KY, Tong CY, Sun Z, Song ZJ. Clinical characteristics and prognosis of community-acquired pneumonia in autoimmune disimmunocompromised host: a retrospective observational study. World J Emerg Med. 2020; 11: 145–151.
  30. Ding J, Karp JE, Emadi A. Elevated lactate dehydrogenase (LDH) can be a marker of immune suppression in cancer: Interplay between hematologic and solid neoplastic clones and their microenvironments. Cancer Biomark. 2017; 19: 353–356.
  31. Zhang JJY, Lee KS, Ang LW, Leo YS, Young BE. Risk Factors for Severe Disease and Efficacy of Treatment in Patients Infected With COVID-19: A Systematic Review, Meta-Analysis and Meta-Regression Analysis. Clin Infect Dis. 2020; 71: 2199–2206.
  32. Peng D, Zhang CJ, Tang Q, Zhang L, Yang KW, Yu XT, Gong Y, Li XS, He ZS, Zhou LQ. Prognostic significance of the combination of preoperative hemoglobin and albumin levels and lymphocyte and platelet counts (HALP) in patients with renal cell carcinoma after nephrectomy. BMC Urol. 2018; 18: 20.
  33. Jiang H, Li H, Li A, Tang E, Xu D, Chen Y, Zhang Y, Tang M, Zhang Z, Deng X et al. Preoperative combined hemoglobin, albumin, lymphocyte and platelet levels predict survival in patients with locally advanced colorectal cancer. Oncotarget. 2016; 7: 72076–72083.
  34. Sakr Y, Lobo S, Knuepfer S, Esser E, Bauer M, Settmacher U, Barz D, Reinhart K. Anemia and blood transfusion in a surgical intensive care unit. Crit Care. 2010; 14: R92.
  35. Zuin M, Rigatelli G, Quadretti L, Fogato L, Zuliani G, Roncon L. Prognostic Role of Anemia in COVID-19 Patients: A Meta-Analysis. Infect Dis Rep. 2021; 13: 930–937.
  36. Paliogiannis P, Mangoni AA, Cangemi M, Fois AG, Carru C, Zinellu A. Serum albumin concentrations are associated with disease severity and outcomes in coronavirus 19 disease (COVID-19): a systematic review and meta-analysis. Clin Exp Med. 2021; 21: 343–354.
  37. Zhang Y, Chen B, Wang L, Wang R, Yang X. Systemic immune-inflammation index is a promising noninvasive marker to predict survival of lung cancer: A meta-analysis. Medicine (Baltimore). 2019; 98: e13788.
  38. Taylor EH, Marson EJ, Elhadi M, Macleod KDM, Yu YC, Davids R, Boden R, Overmeyer RC, Ramakrishnan R, Thomson DA et al. Factors associated with mortality in patients with COVID-19 admitted to intensive care: a systematic review and meta-analysis. Anaesthesia. 2021;76: 1224–1232.
  39. Amgalan A, Othman M. Hemostatic laboratory derangements in COVID-19 with a focus on platelet count. Platelets. 2020; 31: 740–745.
  40. Yilmaz M. Is There Predictive Significance of HALP Score in Metastatic RCC Patients Treated with Nivolumab? EJMI. 2021; 5: 33–38.
Language: English
Page range: 182 - 187
Submitted on: Jan 4, 2023
Accepted on: Nov 13, 2023
Published on: Dec 31, 2023
Published by: Hirszfeld Institute of Immunology and Experimental Therapy
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2023 Mustafa Çolak, Serkan Uçkun, Hikmet Çoban, Nurhan Sarıoğlu, Fuat Erel, published by Hirszfeld Institute of Immunology and Experimental Therapy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.