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A patient infected with SARS-Cov-2 presents with DIHS syndrome induced by olanzapine: diagnostic difficulties Cover

A patient infected with SARS-Cov-2 presents with DIHS syndrome induced by olanzapine: diagnostic difficulties

Open Access
|Oct 2023

Figures & Tables

Table 1.

A detailed description of patient's blood morphology throughout the treatment process and additional key symptoms observed in the process

Days of hospitalization
7910111314
Parameter value in PB
Leukocytes [103 /μl]9.777.476.039.385.96.27
Neutrophils [%]82.762.184.17957.462.4
Eosinophils [%]1.61221.513.48.8
Basophils [%]0.20.800.210.6
Lymphocytes [%]1215.39.115.421.521.5
Monocytes [%]3.49.84.83.99.76.7
Erythrocytes [106 /μl]43.533.23.53.6
Hemoglobin [g/dl]11.210.48.59.310.110.3
Hematocrit [%]34.331.425.727.330.129.8
MCV [10−15 /μl]86.48985.784.58783.5
MCH [pg/cell]28.229.528.328.829.228.9
MCHC [g/dl]32.733.133.134.133.634.6
RDW-CV [%]12.914.9131314.113.8
PLT [10−15 /μl]310365181228305322
MPV [10−15 /μl]111112.712.910.610.9
AspAT [U/l]8764
AlAT [U/l]10997
CRP [mg/l]89.58.1373.213119.121.4
CK [U/l]1144

[i] PB – Peripherical blood

[ii] On Day 7 of hospitalisation, patient presented with an upper lip swelling and maculopapular rash. On Day 9 of hospitalisation, the rash and the swelling have decreased. On Day 10, after olanzapine administration was increased, the patient presented with a 40°C body temperature and eosinophilia visible in the blood smear. On Day 13, patient was diagnosed with bacterial infection of Staphylococcus aureus and Acinetobacter baumani. The antibiotic therapy as well as antihistamine treatment were modified. Since then, patient's state was gradually improving until discharge from the ICU on Day 23.

Language: English
Page range: 99 - 106
Submitted on: Mar 12, 2023
Accepted on: Aug 10, 2023
Published on: Oct 8, 2023
Published by: Hirszfeld Institute of Immunology and Experimental Therapy
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2023 Michalina Pinkosz, Mateusz Szymański, Monika Cendrowska-Pinkosz, published by Hirszfeld Institute of Immunology and Experimental Therapy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.