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The carbohydrate-deficient transferrin as a marker of chronic alcohol consumption and assessment of its usefulness in patients with cardiovascular diseases – a pilot study

Postępy Higieny i Medycyny Doświadczalnej
Volume 77 (2023): Issue 1 (January 2023)
By:
Open Access
|Oct 2023

Figures & Tables

Figure 1.

An representative chromatogram shows the characteristic higher peaks occurring in the case of alcohol consumption - isoform asialotransferrin and disialotransferrin - positive result CDT) - A & sample chromatogram where no asialotransferrin is present and disialotransferrin is much lower – negative CDT - B (Chromsystems, Germany)
An representative chromatogram shows the characteristic higher peaks occurring in the case of alcohol consumption - isoform asialotransferrin and disialotransferrin - positive result CDT) - A & sample chromatogram where no asialotransferrin is present and disialotransferrin is much lower – negative CDT - B (Chromsystems, Germany)

Figure 2.

Analysis of correlation between CDT and NT pro-BNP, troponin T, ALP and GGT
Analysis of correlation between CDT and NT pro-BNP, troponin T, ALP and GGT

Figure 3.

ROC curve analysis of CDT, NT pro-BNP, Troponin T, ALP and GGT parameters to detect patients, for which CDT is over 2.5
ROC curve analysis of CDT, NT pro-BNP, Troponin T, ALP and GGT parameters to detect patients, for which CDT is over 2.5

Figure 4.

ROC curve analysis of CDT, NT pro-BNP, Troponin T, ALP and GGT parameters to detect patients, for which CDT is over 1.2
ROC curve analysis of CDT, NT pro-BNP, Troponin T, ALP and GGT parameters to detect patients, for which CDT is over 1.2

Descriptive statistics for analyzed parameters

CDTNT pro-BNPTroponin TALPGGT
N5959595959
Mean (SD)1.5 (0.9)5 123.1 ( 5911.5)159.4 (576.1)115.6 (89.5)172.3 (175.0)
Median1.32,983.028.192.0102.0
Range0.4 – 5.1180.3 – 33 576.04.2 – 3,694.025.0 – 636.016.0 – 782.0

Area under the ROC curves for different parameters and CDT cut-offs

ParameterAUC95% C.I.
CDT cut-off 2.5
NT pro-BNP0.654(0.475;0.833)
Troponin T0.635(0.406;0.865)
ALP0.733(0.444;1.000)
GGT0.855(0.685;1.000)
CDT cut off 1.2
NT pro-BNP0.716(0.569;0.862)
Troponin T0.445(0.281;0.609)
ALP0.564(0.416;0.713)
GGT0.565(0.413;0.718)
DOI: https://doi.org/10.2478/ahem-2023-0010 | Journal eISSN: 1732-2693
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Language: English
Page range: 91 - 98
Submitted on: May 25, 2022
Accepted on: Mar 31, 2023
Published on: Oct 4, 2023
Published by: Hirszfeld Institute of Immunology and Experimental Therapy
In partnership with: Paradigm Publishing Services
Publication frequency: 1 times per year
Keywords:
carbohydrate deficient transferrin CDT%,
GGT (Gamma-Glutamyl Transferase),
alcohol abuse,
asialotransferrin,
disialotransferrin
Related subjects:
Life sciences,
Molecular biology,
Microbiology and virology,
Medicine,
Basic medical science,
Immunology

© 2023 Joanna Dominika Waś, Magdalena Niedolistek, Dorota Sokołowska, Joanna Wiśniewska, Tomasz Zieliński, Anna Mierzyńska, Daniel Rabczenko, Beata Orzechowska, Dominika Franz, Ewa Augustynowicz-Kopeć, Anna Lutyńska, published by Hirszfeld Institute of Immunology and Experimental Therapy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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