Fig. 1
MiRNAs collected in this review with their targets, marked expression in IBD, and altered TJ proteins expression_ The table was divided into in vivo and in vitro examined effects on TJ proteins expression induced by altered miRNA expression; miRNA–microRNA; ZO-1–Zonula occludens-1; CLDN–Claudin; JAM-A–junctional adhesion molecules A; AJ–adherent junction; CD–-Crohn's disease; UC–-ulcerative colitis; IBD–inflammatory bowel disease; PBMCs–peripheral blood mononuclear cells
| microRNA | Target mRNA | Expression in IBD | TJ proteins expression associated with miRNA-induced effect | Author/year |
|---|---|---|---|---|
| In vivo observed effects | ||||
| miRNA-124a | Aryl hydrocarbon receptor (AhR) | Overexpression in CD tissue | ZO-1 ↓, OCLN ↓, JAM-A ↓, CLDN1 ↓ | Zhao et al., 2020 [58] |
| miRNA-31-5p | Activin receptor-like type 1 (ALK1) | Overexpression in CD tissue | CLDN8 ↓, TJP1 ↓, OCLN ↓ | Toyonaga et al., 2020 [39] |
| miRNA-301A | B-cell translocation gene 1 (BTG1) | Overexpression in PBMCs and tissue in IBD | E-cadherin (AJ) ↓ | He et al., 2017 [86] |
| miRNA-200b | Myosin light chain kinase (MLCK) and c-JUN | Decreased in IBD tissue | ZO-1 ↓, OCLN ↓ | Shen et al., 2017 [64] |
| miRNA-21 | Claudin 8 (CLDN8) | Overexpression in CD tissue | CLDN8 ↓ | Li et al., 2018 [71] |
| miRNA-200c-3p | Occludin (OCLN) | Overexpression in UC tissue | OCLN ↓ | Rawat et al., 2020 [81] |
| miRNA-495 | Signal transducer and activator of transcription 3 (STAT3) | Decreased in UC tissue | CLDN1 ↓ | Chu et al., 2018 [90] |
| miRNA-122a | Epidermal growth factor receptor (EGFR) | Overexpression in IBD tissue | CLDN1 ↓, OCLN ↓, Zonulin ↑ | Zhang et al., 2017 [92] |
| miRNA-320a | Protein phosphatase 2 (PP2A) and Cell division cycle 42 (Cdc42) | Overexpression in serum of active CD | JAM-A ↑ | Cordes et al., 2016 [106] |
| miRNA-423-5p | CLDN5 | Overexpression in UC tissue | CLDN5 ↓ | Wang et al., 2020 [77] |
| In vitro observed effects | ||||
| miRNA-185-3p | Myosin light chain kinase (MLCK) | Decreased in IBD tissue | ZO-1 ↓, OCLN ↓ | Ma et al., 2019 [63] |
| miRNA-23a | Tumor necrosis factor alpha inhibitor protein 3 (TNFAIP3) | Overexpression in CD tissue | OCLN destabilization | Felwick et al., 2020 [33] |
| miRNA-675-5p | Vitamin D receptor (VDR) | Overexpression in UC tissue | ZO-1 ↓, OCLN ↓ | Chen et al., 2016 [52] |
| miRNA-375 | Toll-like receptor 4 (TLR4) | Decreased in IBD tissue | ZO-1 ↓, OCLN ↓ | Wu et al., 2019 [98] |
| miRNA-223 | Claudin 8 (CLDN8) | Overexpression in IBD tissue | CLDN8 ↓ | Wang et al., 2016 [68] |