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Cotinine as an indicator of fetal exposure to active and passive smoking in pregnant women Cover

Cotinine as an indicator of fetal exposure to active and passive smoking in pregnant women

Open Access
|Aug 2022

Figures & Tables

Place of exposure of pregnant women to tobacco smoke

Smoking during pregnancy
NoYes
WorkplaceNoN7120p = 0.235
%86.60%76.90%
YesN116
%13.40%23.10%
Parents’ homeNoN7011χ2(1) = 19.52p < 0.001V = 0.43
%85.40%42.30%
YesN1215
%14.60%57.70%
At friendsNoN6916χ2(1) = 6.02p = 0.014V = 0.24
%84.10%61.50%
YesN1310
%15.90%38.50%
OtherNoN7225p = 0.291
%87.80%96.20%
YesN101
%12.20%3.80%

Demographic characteristics of the study group of 123 pregnant women

AgeResidenceEducation
18–3031–38Rural areasCityVocationalSecondaryHigher
109144578335040
89%11%36%64%27%41%32%

Cigarette smoking by pregnant women and their passive exposure to smoke, in relation to cotinine blood levels

Cotinine level
Higher in cord bloodHigher in mother's bloodSame (75 pg/ml)
Smoking during pregnancyNoN8516
%34.80%21.70%61.50%
YesN151810
%65.20%*78.30%38.50%
χ2(2) = 6.83; p = 0.033; V = 0.31
Exposure to cigarette smoke during pregnancyNoN81220
%34.80%50.00%76.90%
YesN15126
%65.20%*50.00%23.10%
χ2(2) = 9.08; p = 0.011; V=0.35

Cotinine levels in the blood of smoking and non-smoking mothers and in the cord blood of their children

Smoking while pregnant
No (n = 97)Yes (n = 26)
MSDMSDUZpr
Cotinine - mother's blood [ng/mL]3.4116.2051.4253.82174.0−6.35≤0.0010.62
Cotinine - cord blood [ng/mL]2.7212.1048.7054.66187.0−6.28≤0.0010.61

Frequency of smoking by parents of the survey subjects

Smoking parents in a group of 97 pregnant non-smokersSmoking parents among 26 pregnant smokersTotal - 123
N%N%N%
Father35365194033
Mother885191310
Both parents29308313730

Frequency of smoking by people in the immediate environment of pregnant women, including smoking by pregnant women

Smoking during pregnancy
NoYes
Husband who is a smokerNoN668χ2(1) = 22.62p < 0.001V = 0.46
%80.50%30.80%
YesN1618
%19.50%69.20%
Parents who are smokersNoN5611χ2(1) = 5.66p = 0.017V = 0.23
%68.30%42.30%
YesN2615
%31.70%57.70%
Grandparents who are smokersNoN7723p = 0.396
%93.90%88.50%
YesN53
%6.10%11.50%
Friends who are smokersNoN5512χ2(1) = 3.67p = 0.055V = 0.18

Cotinine levels in the blood of the mother and the umbilical cord blood of the newborn depending on the smoking of tobacco by family members and friends of the respondents

Husband who is a smokerNo (n = 48)Yes (n = 56)
MSDMSDUZpr
Cotinine - mother's blood [ng/mL]6.6519.1632.7753.39614.0−4.10≤0.0010.40
Cotinine - cord blood [ng/mL]6.9019.0828.7151.87599.5−4.22≤0.0010.41
Grandparents who are smokersNo (n = 96)Yes (n = 8)
MSDMSDUZpr
Cotinine - mother's blood [ng/mL]14.4236.0827.7342.71266.0−1.440.1490.14
Cotinine - cord blood [ng/mL]13.1034.0627.9147.02253.0−1.610.1070.16
Friends who are smokersNo (n = 45)Yes (n = 27)
MSDMSDUZpr
Cotinine - mother's blood [ng/mL]16.1440.6414.3629.68984.5−2.050.0410.20
Cotinine - cord blood [ng/mL]14.9239.1813.2028.30972.5−2.140.0320.21
Language: English
Page range: 358 - 368
Submitted on: Sep 3, 2021
Accepted on: Dec 7, 2021
Published on: Aug 9, 2022
Published by: Hirszfeld Institute of Immunology and Experimental Therapy
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2022 Marta Dulęba, Barbara Kozakiewicz, published by Hirszfeld Institute of Immunology and Experimental Therapy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.