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Is combined physical therapy more effective than topical hyperbaric oxygen therapy in the treatment of venous leg ulcers? Preliminary study Cover

Is combined physical therapy more effective than topical hyperbaric oxygen therapy in the treatment of venous leg ulcers? Preliminary study

Postępy Higieny i Medycyny Doświadczalnej
Volume 76 (2022): Issue 1 (January 2022)
By: ,  ,  ,   and    
Open Access
|Jun 2022
Figures & tables

Figures & Tables

Table 1

Clinical characteristics of the studied population of patients

ParameterGroup I treated with OXYBAR-IA-S deviceGroup II treated with LASEROBAR-IA-S deviceStatistical significance
Women7 (38.9%)7 (38.9%)p=1.000
Men11 (61.1%)11 (61.1%)
Age70.94 ± 10.8666.83 ± 7.20p=0.055
Diabetes7 (38.9%)9 (50.0%)p=0.170
Venous insufficiency9 (50.0%)8 (44.4%)p=0.740
Atherosclerosis15 (83.3%)17 (94.4%)p=0.280
Bacterial contamination16 (88.9%)14 (77.8%)p=0.365
Table 2

Comparison of ulceration surface areas measured by means of planimetric method (mean ± SD) in patients from both study groups before the beginning of therapeutic cycle and after its completion, with statistical assessment

GroupSurface area before the therapeutic cycle (average± SD)Surface area after the therapeutic cycle (average± SD)Statistical significance
Group I treated with OXYBARIA-S device25.11 ± 17.816.93 ± 13.89p=0.0002
Group II treated with LASEROBARIA-S device34.17 ± 14.8223.99 ± 15.15p=0.004
Statistical significance Group I vs. Group IIp=0.071p=0.169
Table 3

Comparison of selected blood morphology parameters (mean± SD) in patients from both study groups, before the beginning of therapeutic cycle and after its completion, with statistical evaluation

ParameterGroup I treated with OXYBARIA-S deviceGroup II treated with LASEROBARIA-S deviceStatistical significance Group I vs. Group II
Leukocytes [G/l] before treatment
after treatment		8.02±2.63
6.81±2.15		8.30±2.33
7.26±1.56		p=0.709
p=0.484
Statistical significance
before treatment vs after treatment		p=0.35p=0.01
Erythrocytes [T/l] before treatment
after treatment		4.28±0.65
4.13±0.70		4.40±0.54
4.17±0.49		p=0.660
p=0.846
Statistical significance
before treatment vs after treatment		p=0.23p=0.21
Hemoglobin [g/dl] before treatment
after treatment		12.22 ± 1.79
11.82 ± 1.96		12.70 ± 1.59
12.10 ± 1.87		p=0.425
p=0.666
Statistical significance
before treatment vs after treatment		p=0.08p=0.22
Haematocrit [%]
before treatment
after treatment		37.71 ± 5.40
36.81 ± 6.07		39.70 ± 5.07
37.38 ± 5.65		p=0.259
p=0.769
Statistical significance
before treatment vs after treatment		p=0.52p=0.19
MCV [fl]
before treatment
after treatment		88.57 ± 6.89
89.37 ± 5.75		91.10 ± 5.01
89.43 ± 6.75		p=0.222
p=0.977
Statistical significance
before treatment vs after treatment		p=0.53p=0.72
MCH [pg]
before treatment
after treatment		28.78 ± 3.02
28.69 ± 1.85		29.10 ± 2.00
29.97 ± 2.71		p=0.698
p=0.722
Statistical significance
before treatment vs after treatment		p=0.63p=0.80
MCHC [g/dl]
before treatment
after treatment		32.44 ± 1.16
32.13 ± 1.14		32.00 ± 1.39
32.36 ± 1.14		p=0.264
p=0.561
Statistical significance
before treatment vs after treatment		p=0.63p=0.87
RDW-CV [%]
before treatment
after treatment		13.77 ± 1.65
13.56 ± 1.29		13.70 ± 1.53
13.51 ± 1.85		p=0.942
p=0.926
Statistical significance
before treatment vs after treatment		p=0.90p=0.36
Platelets [tys./µl] before treatment
after treatment		271.3 ± 157.7
248.6 ± 208.2		248.9 ± 75.8
229.5 ± 67.9		p=0.591
p=0.713
Statistical significance
before treatment vs after treatment		p=0.39p=0.54
MPV [fl]
before treatment
after treatment		6.75 ± 1.29
6.86 ± 1.23		7.00 ± 0.91
6.72 ± 0.86		p=0.434
p=0.685
Statistical significance
before treatment vs after treatment		p=0.61p=0.66
Neutrophils [%]
before treatment
after treatment		67.11 ± 8.01
58.88 ± 10.26		63.10 ± 10.32
56.64 ± 9.86		p=0.199
p=0.509
Statistical significance
before treatment vs after treatment		p=0.73p=0.01
Lymphocytes [%]
before treatment
after treatment		21.81 ± 6.50
26.24 ± 9.95		25.90 ± 9.72
31.02 ± 9.75		p=0.150
p=0.155
Statistical significance
before treatment vs after treatment		p=0.79p=0.05
Monocytes [%]
before treatment
after treatment		7.73 ± 2.19
8.47 ± 2.68		7.00 ± 2.05
7.71 ± 1.97		p=0.289
p=0.083
Statistical significance
before treatment vs after treatment		p=0.01p=0.01
Eosinophils [%]
before treatment
after treatment		2.51 ± 3.34
4.26 ± 2.65		3.30 ± 2.39
3.77 ± 1.79		p=0.427
p=0.516
Statistical significance
before treatment vs after treatment		p=0.15p=0.01
Basophils [%]
before treatment
after treatment		0.70 ± 0.15
0.96 ± 0.35		0.80 ± 0.20
0.87 ± 0.24		p=0.346
p=0.364
Statistical significance
before treatment vs after treatment		p=0.58p=0.43
Table 4

Comparison of selected blood coagulation parameters (mean ± SD) in patients from both study groups, before the beginning of therapeutic cycle and after its completion, with statistical evaluation

ParameterGroup I treated with OXYBARIA-S deviceGroup II treated with LASEROBARIA-S deviceStatistical significance Group I vs Group II
Fibrinogen [g/l]
before treatment
after treatment		4.22±1.28
3.39 ± 0.68		4.05±1.36
3.5 ± 0.71		p=0.708
p=0.569
Statistical significance
before treatment vs after treatment		p=0.01p<0.001
Kaolin-cephalintime (aPTT)[s]
before treatment
after treatment		33.76±9.77
37.19 ± 11.97		31.85±9.42
31.4 ± 10.17		p=0.554
p=0.130
Statistical significance
before treatment vs after treatment		p=0.16p=0.45
Prothrombin time[s]
before treatment
after treatment		11.75±0.90
11.75 ± 0.90		11.80±1.10
12.0 ± 0.60		p=0.704
p=0.287
Statistical significance
before treatment vs after treatment		p=0.19p=0.29
International Normalized Ratio (INR)
before treatment
after treatment		1.15±0.25
1.20 ± 0.20		1.10±0.15
1.21 ± 0.12		p=0.751
p=0.282
Statistical significance
before treatment vs after treatment		p=0.20p=0.35
Table 5

Comparison of selected biochemical parameters (mean ± SD) in blood serum of patients from both study groups, before the beginning of therapeutic cycle and after its completion, with statistical evaluation

ParameterGroup I treated With OXYBARIA-SGroup II treated with LASEROBARIA-SStatistical significance Group I vs Group II
Glucose [mg/dl]
before treatment
after treatment		105.45 ±7.55
91.50±9.45		101.60± 12.55
100.1± 12.43		p=0.880
p=0.067
Statistical significance
before treatment vs after treatment		p=0.04p=0.08
Total cholesterol[mg/dl]
before treatment
after treatment		140.83±33.31
134.39±34.40		146.33±38.82
138.5±27.58		p=0.842
p=0.695
Statistical significance
before treatment vs after treatment		p=0.59p=0.04
Cholesterol-LDL[mg/dl]
before treatment
after treatment		85.78±33.35
81.33±33.19		107.56±31.41
84.2±25.10		p=0.052
p=0.770
Statistical significance
before treatment vs after treatment		p=0.68p=0.06
Cholesterol-HDL[mg/dl]
before treatment
after treatment		45.89±9.97
41.22±9.53		51.26±12.42
43.6±8.22		p=0.162
p=0.424
Statistical significance
before treatment vs after treatment		p=0.22p=0.03
Triglycerides [mg/dl]
before treatment
after treatment		107.72±32.09
117.44±39.83		119.06±55.01
114.6±39.13		p=0.455
p=0.831
Statistical significance
before treatment vs after treatment		p=0.50p=0.80
Total protein[g/dl]
before treatment
after treatment		7.22±0.60
6.69±0.46		7.00±0.71
6.60 ±0.65		p=0.319
p=0.585
Statistical significance
before treatment vs after treatment		p=0.01p=0.01
Sodium [mmol/l]
before treatment
after treatment		139.44±2.57
137.89±4.59		138.94±3.02
139.8±3.45		p=0.596
p=0.160
Statistical significance
before treatment vs after treatment		p=0.24p=0.69
Potassium [mmol/l] before treatment
after treatment		4.83±0.53
4.64±0.55		4.58±0.50
4.40 ±0.38		p=0.149
p=0.122
Statistical significance
before treatment vs after treatment		p=0.23p=0.09
Creatinine [mg/dl]
before treatment
after treatment		0.93±1.94
0.88±0.15		0.96±0.13
1.00 ±0.16		p=0.776
p=0.281
Statistical significance
before treatment vs after treatment		p=0.82p=0.74
Urea [mg/dl]
before treatment
after treatment		43.45±11.1
45.55±15.04		34.85±12.40
38.90 ±5.42		p=0.704
p=0.248
Statistical significance
before treatment vs after treatment		p=0.46p=0.70
Uricacid [mg/dl]
before treatment
after treatment		6.28±1.29
6.29±1.93		6.03±2.09
5.90 ±2.10		p=0.676
p=0.529
Statistical significance
before treatment vs after treatment		p=0.97p=0.82
C Reactive Protein (CRP) [mg/l]
before treatment
after treatment		14.99 ± 16.20
11.26±14.31		20.66 ± 25.79
8.21±7.68		p=0.790
p=0.765
Statistical significance
before treatment vs after treatment		p=0.52p=0.05
DOI: https://doi.org/10.2478/ahem-2022-0023 | Journal eISSN: 1732-2693
Journal RSS Feed
Language: English
Page range: 199 - 208
Submitted on: Aug 23, 2021
Accepted on: Dec 9, 2021
Published on: Jun 4, 2022
Published by: Hirszfeld Institute of Immunology and Experimental Therapy
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year
Keywords:
biochemical blood parameters,
venous leg ulcers,
hyperbaric oxygen therapy,
combined physical therapy,
treatment
Related subjects:
Life sciences,
Molecular biology,
Microbiology and virology,
Medicine,
Basic medical science,
Immunology

© 2022 Mikołaj Pietrzak, Jarosław Pasek, Sebastian Szajkowski, Karol Szyluk, Grzegorz Cieślar, published by Hirszfeld Institute of Immunology and Experimental Therapy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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