Is combined physical therapy more effective than topical hyperbaric oxygen therapy in the treatment of venous leg ulcers? Preliminary study

Pietrzak, Mikołaj; Pasek, Jarosław; Szajkowski, Sebastian; Szyluk, Karol; Cieślar, Grzegorz

doi:10.2478/ahem-2022-0023

Figures & Tables

Comparison of selected blood coagulation parameters (mean ± SD) in patients from both study groups, before the beginning of therapeutic cycle and after its completion, with statistical evaluation

Parameter	Group I treated with OXYBARIA-S device	Group II treated with LASEROBARIA-S device	Statistical significance Group I vs Group II
Fibrinogen [g/l]before treatmentafter treatment	4.22±1.283.39 ± 0.68	4.05±1.363.5 ± 0.71	p=0.708p=0.569
Statistical significancebefore treatment vs after treatment	p=0.01	p<0.001
Kaolin-cephalintime (aPTT)[s]before treatmentafter treatment	33.76±9.7737.19 ± 11.97	31.85±9.4231.4 ± 10.17	p=0.554p=0.130
Statistical significancebefore treatment vs after treatment	p=0.16	p=0.45
Prothrombin time[s]before treatmentafter treatment	11.75±0.9011.75 ± 0.90	11.80±1.1012.0 ± 0.60	p=0.704p=0.287
Statistical significancebefore treatment vs after treatment	p=0.19	p=0.29
International Normalized Ratio (INR)before treatmentafter treatment	1.15±0.251.20 ± 0.20	1.10±0.151.21 ± 0.12	p=0.751p=0.282
Statistical significancebefore treatment vs after treatment	p=0.20	p=0.35

Comparison of selected biochemical parameters (mean ± SD) in blood serum of patients from both study groups, before the beginning of therapeutic cycle and after its completion, with statistical evaluation

Parameter	Group I treated With OXYBARIA-S	Group II treated with LASEROBARIA-S	Statistical significance Group I vs Group II
Glucose [mg/dl]before treatmentafter treatment	105.45 ±7.5591.50±9.45	101.60± 12.55100.1± 12.43	p=0.880p=0.067
Statistical significancebefore treatment vs after treatment	p=0.04	p=0.08
Total cholesterol[mg/dl]before treatmentafter treatment	140.83±33.31134.39±34.40	146.33±38.82138.5±27.58	p=0.842p=0.695
Statistical significancebefore treatment vs after treatment	p=0.59	p=0.04
Cholesterol-LDL[mg/dl]before treatmentafter treatment	85.78±33.3581.33±33.19	107.56±31.4184.2±25.10	p=0.052p=0.770
Statistical significancebefore treatment vs after treatment	p=0.68	p=0.06
Cholesterol-HDL[mg/dl]before treatmentafter treatment	45.89±9.9741.22±9.53	51.26±12.4243.6±8.22	p=0.162p=0.424
Statistical significancebefore treatment vs after treatment	p=0.22	p=0.03
Triglycerides [mg/dl]before treatmentafter treatment	107.72±32.09117.44±39.83	119.06±55.01114.6±39.13	p=0.455p=0.831
Statistical significancebefore treatment vs after treatment	p=0.50	p=0.80
Total protein[g/dl]before treatmentafter treatment	7.22±0.606.69±0.46	7.00±0.716.60 ±0.65	p=0.319p=0.585
Statistical significancebefore treatment vs after treatment	p=0.01	p=0.01
Sodium [mmol/l]before treatmentafter treatment	139.44±2.57137.89±4.59	138.94±3.02139.8±3.45	p=0.596p=0.160
Statistical significancebefore treatment vs after treatment	p=0.24	p=0.69
Potassium [mmol/l] before treatmentafter treatment	4.83±0.534.64±0.55	4.58±0.504.40 ±0.38	p=0.149p=0.122
Statistical significancebefore treatment vs after treatment	p=0.23	p=0.09
Creatinine [mg/dl]before treatmentafter treatment	0.93±1.940.88±0.15	0.96±0.131.00 ±0.16	p=0.776p=0.281
Statistical significancebefore treatment vs after treatment	p=0.82	p=0.74
Urea [mg/dl]before treatmentafter treatment	43.45±11.145.55±15.04	34.85±12.4038.90 ±5.42	p=0.704p=0.248
Statistical significancebefore treatment vs after treatment	p=0.46	p=0.70
Uricacid [mg/dl]before treatmentafter treatment	6.28±1.296.29±1.93	6.03±2.095.90 ±2.10	p=0.676p=0.529
Statistical significancebefore treatment vs after treatment	p=0.97	p=0.82
C Reactive Protein (CRP) [mg/l]before treatmentafter treatment	14.99 ± 16.2011.26±14.31	20.66 ± 25.798.21±7.68	p=0.790p=0.765
Statistical significancebefore treatment vs after treatment	p=0.52	p=0.05

Clinical characteristics of the studied population of patients

Parameter	Group I treated with OXYBAR-IA-S device	Group II treated with LASEROBAR-IA-S device	Statistical significance
Women	7 (38.9%)	7 (38.9%)	p=1.000
Men	11 (61.1%)	11 (61.1%)	p=1.000
Age	70.94 ± 10.86	66.83 ± 7.20	p=0.055
Diabetes	7 (38.9%)	9 (50.0%)	p=0.170
Venous insufficiency	9 (50.0%)	8 (44.4%)	p=0.740
Atherosclerosis	15 (83.3%)	17 (94.4%)	p=0.280
Bacterial contamination	16 (88.9%)	14 (77.8%)	p=0.365

Comparison of ulceration surface areas measured by means of planimetric method (mean ± SD) in patients from both study groups before the beginning of therapeutic cycle and after its completion, with statistical assessment

Group	Surface area before the therapeutic cycle (average± SD)	Surface area after the therapeutic cycle (average± SD)	Statistical significance
Group I treated with OXYBARIA-S device	25.11 ± 17.8	16.93 ± 13.89	p=0.0002
Group II treated with LASEROBARIA-S device	34.17 ± 14.82	23.99 ± 15.15	p=0.004
Statistical significance Group I vs. Group II	p=0.071	p=0.169

Comparison of selected blood morphology parameters (mean± SD) in patients from both study groups, before the beginning of therapeutic cycle and after its completion, with statistical evaluation

Parameter	Group I treated with OXYBARIA-S device	Group II treated with LASEROBARIA-S device	Statistical significance Group I vs. Group II
Leukocytes [G/l] before treatmentafter treatment	8.02±2.636.81±2.15	8.30±2.337.26±1.56	p=0.709p=0.484
Statistical significancebefore treatment vs after treatment	p=0.35	p=0.01
Erythrocytes [T/l] before treatmentafter treatment	4.28±0.654.13±0.70	4.40±0.544.17±0.49	p=0.660p=0.846
Statistical significancebefore treatment vs after treatment	p=0.23	p=0.21
Hemoglobin [g/dl] before treatmentafter treatment	12.22 ± 1.7911.82 ± 1.96	12.70 ± 1.5912.10 ± 1.87	p=0.425p=0.666
Statistical significancebefore treatment vs after treatment	p=0.08	p=0.22
Haematocrit [%]before treatmentafter treatment	37.71 ± 5.4036.81 ± 6.07	39.70 ± 5.0737.38 ± 5.65	p=0.259p=0.769
Statistical significancebefore treatment vs after treatment	p=0.52	p=0.19
MCV [fl]before treatmentafter treatment	88.57 ± 6.8989.37 ± 5.75	91.10 ± 5.0189.43 ± 6.75	p=0.222p=0.977
Statistical significancebefore treatment vs after treatment	p=0.53	p=0.72
MCH [pg]before treatmentafter treatment	28.78 ± 3.0228.69 ± 1.85	29.10 ± 2.0029.97 ± 2.71	p=0.698p=0.722
Statistical significancebefore treatment vs after treatment	p=0.63	p=0.80
MCHC [g/dl]before treatmentafter treatment	32.44 ± 1.1632.13 ± 1.14	32.00 ± 1.3932.36 ± 1.14	p=0.264p=0.561
Statistical significancebefore treatment vs after treatment	p=0.63	p=0.87
RDW-CV [%]before treatmentafter treatment	13.77 ± 1.6513.56 ± 1.29	13.70 ± 1.5313.51 ± 1.85	p=0.942p=0.926
Statistical significancebefore treatment vs after treatment	p=0.90	p=0.36
Platelets [tys./µl] before treatmentafter treatment	271.3 ± 157.7248.6 ± 208.2	248.9 ± 75.8229.5 ± 67.9	p=0.591p=0.713
Statistical significancebefore treatment vs after treatment	p=0.39	p=0.54
MPV [fl]before treatmentafter treatment	6.75 ± 1.296.86 ± 1.23	7.00 ± 0.916.72 ± 0.86	p=0.434p=0.685
Statistical significancebefore treatment vs after treatment	p=0.61	p=0.66
Neutrophils [%]before treatmentafter treatment	67.11 ± 8.0158.88 ± 10.26	63.10 ± 10.3256.64 ± 9.86	p=0.199p=0.509
Statistical significancebefore treatment vs after treatment	p=0.73	p=0.01
Lymphocytes [%]before treatmentafter treatment	21.81 ± 6.5026.24 ± 9.95	25.90 ± 9.7231.02 ± 9.75	p=0.150p=0.155
Statistical significancebefore treatment vs after treatment	p=0.79	p=0.05
Monocytes [%]before treatmentafter treatment	7.73 ± 2.198.47 ± 2.68	7.00 ± 2.057.71 ± 1.97	p=0.289p=0.083
Statistical significancebefore treatment vs after treatment	p=0.01	p=0.01
Eosinophils [%]before treatmentafter treatment	2.51 ± 3.344.26 ± 2.65	3.30 ± 2.393.77 ± 1.79	p=0.427p=0.516
Statistical significancebefore treatment vs after treatment	p=0.15	p=0.01
Basophils [%]before treatmentafter treatment	0.70 ± 0.150.96 ± 0.35	0.80 ± 0.200.87 ± 0.24	p=0.346p=0.364
Statistical significancebefore treatment vs after treatment	p=0.58	p=0.43

Is combined physical therapy more effective than topical hyperbaric oxygen therapy in the treatment of venous leg ulcers? Preliminary study

Figures & Tables

Comparison of selected blood coagulation parameters (mean ± SD) in patients from both study groups, before the beginning of therapeutic cycle and after its completion, with statistical evaluation

Comparison of selected biochemical parameters (mean ± SD) in blood serum of patients from both study groups, before the beginning of therapeutic cycle and after its completion, with statistical evaluation

Clinical characteristics of the studied population of patients

Comparison of ulceration surface areas measured by means of planimetric method (mean ± SD) in patients from both study groups before the beginning of therapeutic cycle and after its completion, with statistical assessment

Comparison of selected blood morphology parameters (mean± SD) in patients from both study groups, before the beginning of therapeutic cycle and after its completion, with statistical evaluation

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