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Diabetes mellitus type 2 does not influence carotid stiffness in patients on maintenance hemodialysis Cover

Diabetes mellitus type 2 does not influence carotid stiffness in patients on maintenance hemodialysis

Postępy Higieny i Medycyny Doświadczalnej
Volume 75 (2021): Issue 1 (January 2021)
By: ,  ,   and    
Open Access
|Dec 2021
Figures & tables

Figures & Tables

Table 1.

Chronic kidney disease etiology

Diabetic N=37 n (%)Nondiabetic N=53 n (%)P
Hypertensive nephropathy22 (59.5)11 (20.8)<0.001
Diabetic nephropathy8 (21.6)0 (0)<0.001
Chronic glomerular disease3 (8.1)21 (39.6)<0.001
Polycystic kidney disease1 (2.7)7 (13.2)0.18
Interstitial nephropathy2 (5.4)8 (15.1)0.12
Other1 (2.7)7 (13.2)0.08
Table 2.

Cardiovascular co-morbidity

Diabetic N=37 n (%)Non-diabetic N=53 n (%)P
Arterial hypertension31 (83.8)38 (71.7)0.18
Myocardial infarction8 (21.6)7 (13.2)0.29
Coronary artery disease21 (56.8)17 (32.1)0.02
Coronary artery bypass graft6 (16.2)1 (1.9)0.01
Percutaneous cardiac intervention9 (24.3)7 (13.2)0.17
Stroke8 (21.6)4 (7.6)0.053
Table 3.

Basic demographic, clinical, hemodialysis, and laboratory data in the diabetic and non-diabetic groups.

Diabetic N=37 median (IQR)Non diabetic N=53 median (IQR)p
Age [years]67 [59-76]62 [46-76]0.13
Male gender, n (%)15 [40.55]28 [52.83]0.25
Female gender, n (%)22 [59.45]25 [47.17]0.25
Weight before hemodialysis [kg]74.4 [61.2-91.3]67.7 [60.9-80.3]0.40
Body mass index [kg/m2]27.3 [22.5-30.8]24.6 [23.0-27.6]0.06
Left ventricular ejection fraction [%]60 [50-65]60 [50-60]0.94
Duration of HD therapy [months]31.0 [10-58.5]33.8 [9.5-95.0]0.68
Ultrafiltration [L]1.9 [1.3-2.5]1.8 [1.0-2.0]0.20
Adequacy of hemodialysis [kT/V]1.28 [1.11-1.50]1.40 [1.10-1.65]0.22
SBP before HD [mmHg]145 [120-150]145 [130-160]0.43
SBP after HD [mmHg]140 [125-160]130 [120-158]0.56
DBP before HD [mmHg]70 [60-80]80 [70-90]0.019
DBP after HD [mmHg]73 [65-80]80 [70-89.5]0.27
HR before HD [mmHg]75 [61-86]72 [67-79]0.72
HR after HD [mmHg]72.5 [63-83]80 [65-84]0.55
Urea before HD [mg/dl]114 [92-132]117 [99-137]0.65
Urea after HD [mg/dl]36 [27-47]35 [26-46]0.68
Creatinine before HD [mg/dl]6.46 [3.35-7.95]8.04 [5.57-9.65]0.038
Creatinine after HD [mg/dl]2.73 [1.99-3.81]2.73 [2.15-4.26]0.44
Hemoglobin [g/dl]10.8 [9.4-11.4]10.4 [9.5-12.1]0.95
Total cholesterol [mg/dl]167 [142-209]171 [146-209]0.76
High-density lipoprotein [mg/dl]40 [34-46]42 [36-48]0.58
Low-density lipoprotein [mg/dl]92 [69-129]95 [76-120]0.83
Triglycerides [mg/dl]165 [119-263]146 [95-221]0.13
C-reactive protein [mg/l]5.63 [3.03-23.07]8.48 [3.2-19.5]0.69
Glucose [mg/dl]153 [118-203]98 [90-112]< 0.001

1 SBP – systolic blood pressure; DBP – diastolic blood pressure; HR- heart rate

HD – hemodialysis

Table 4.

Carotid stiffness parameters assessed by means of echo tracking between diabetic and non-diabetic patients

Diabetic N=37 median (IQR)Non-diabetic N=53 median (IQR)p
β before HD7.65 [5.35–10.55]7.85 [4.7–10.8]0.91
β after HD7.7 [5.3–9.0]7.1 [5.35–8.65]0.53
PWV β before HD [m/s]5.95 [4.55–7.15]5.9 [4.8–7.3]0.77
PWV β after HD [m/s]5.8 [4.7–6.5]5.8 [5.100–6.425]0.92
AC before HD [mm2/kPa]0.71 [0.56–1.24]0.795 [0.530–1.020]0.49
AC after HD [mm2/kPa]0.87 [0.68–1.04]0.765 [0.570–1.000]0.29
Ep before HD [kPa]103 [67–146]116 [69–155]0.76
Ep after HD [kPa]99 [68–139]95 [72–119]0.64

1 HD – hemodialysis; β – beta stiffness index; PWVβ – one-point pulse wave velocity; AC – arterial compliance; Ep – epsilon

Table 5.

Cardiovascular and non-cardiovascular mortality – comparison in both groups

Survived N=47 ptsCardiovascular death N=19 ptsNon-cardiovascular death N=24 pts
Non-diabetic patients N=5374.47% (35)52.63% (10)33.33% (8)
Diabetic patients N=3725.53% (12)47.37% (9)66.67% * (16)

1* p<0.01

DOI: https://doi.org/10.2478/ahem-2021-0046 | Journal eISSN: 1732-2693
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Language: English, Polish
Page range: 1012 - 1019
Submitted on: Mar 8, 2021
Accepted on: Aug 17, 2021
Published on: Dec 30, 2021
Published by: Hirszfeld Institute of Immunology and Experimental Therapy
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year
Keywords:
Chronic kidney disease,
echo-tracking,
diabetes mellitus,
hemodialysis,
arterial stiffness
Related subjects:
Life sciences,
Molecular biology,
Microbiology and virology,
Medicine,
Basic medical science,
Immunology

© 2021 Konrad Rekucki, Agnieszka Sławuta, Marta Obremska, Katarzyna Madziarska, published by Hirszfeld Institute of Immunology and Experimental Therapy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Volume 75 (2021): Issue 1 (January 2021)
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