Molekularne mechanizmy działania czynnika transkrypcyjnego FOXN1 w skórze

Barbara Gawrońska-Kozak; Anna Kur-Piotrowska; Joanna Wiśniewska; Marta Kopcewicz

doi:10.2478/ahem-2021-0028

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Molekularne mechanizmy działania czynnika transkrypcyjnego FOXN1 w skórze

Postępy Higieny i Medycyny Doświadczalnej

Volume 75 (2021): Issue 1 (January 2021)

By: Barbara Gawrońska-Kozak, Anna Kur-Piotrowska, Joanna Wiśniewska and Marta Kopcewicz

Open Access

|Oct 2021

Abstract

The review focuses on the research related to the function and the molecular mechanisms of transcription factor FOXN1 action. In mammals, FOXN1 is localized in the epithelium of the skin and thymus. In the skin, FOXN1 stimulates keratinocytes differentiation, regulates pigmentation process and participates in hair development and cycling. In skin wound healing processes, FOXN1 contributes to scar formation due to its involvement in reepithelialization and epithelialmesenchymal transition (EMT). Foxn1^-/^- mice displayed regenerative (scar-free) skin wound healing resolution, which is unique for adult mammals but characteristic for mammalian fetuses. A detailed comparative analysis of transcriptomes from the skin of adult Foxn1^-/^- mice and the skin of mouse fetuses (14^th day of embryonic development) revealed substantial similarities in the gene expression related to tissue remodelling, cytoskeletal rearrangements, wound healing, the immune response and differentiation. The results suggest that FOXN1 is a key factor regulating the transition from scar-free (regenerative) to scar-forming (reparative) skin wound healing process during fetal development

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Articles in this issue

DOI: https://doi.org/10.2478/ahem-2021-0028 | Journal eISSN: 1732-2693

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Language: English, Polish

Page range: 573 - 583

Submitted on: Oct 1, 2020

Accepted on: Jun 17, 2021

Published on: Oct 21, 2021

Published by: Hirszfeld Institute of Immunology and Experimental Therapy

In partnership with: Paradigm Publishing Services

Publication frequency: 1 issue per year

Keywords:

Transcription factor,

FOXN1,

skin,

Related subjects:

Microbiology and virology,

Medicine,

Basic medical science,

Immunology

© 2021 Barbara Gawrońska-Kozak, Anna Kur-Piotrowska, Joanna Wiśniewska, Marta Kopcewicz, published by Hirszfeld Institute of Immunology and Experimental Therapy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Volume 75 (2021): Issue 1 (January 2021)