Fototerapia – metoda wykorzystywana w leczeniu przewlekłych schorzeń dermatologicznych

Klaudia Banach; Marta Karkoszka; Dorota Wrześniok

doi:10.2478/ahem-2021-0010

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Fototerapia – metoda wykorzystywana w leczeniu przewlekłych schorzeń dermatologicznych

Postępy Higieny i Medycyny Doświadczalnej

Volume 75 (2021): Issue 1 (January 2021)

By: Klaudia Banach, Marta Karkoszka and Dorota Wrześniok

Open Access

|Dec 2021

Abstract

Light energy is used in the therapy of various etiology diseases since ancient times. The main element determining the success of the therapy is the selection of the appropriate radiation length (NB-UVB, BB-UVB and UVA1 therapy) or the interaction between the photosensitive substance accumulated in the diseased tissue and the radiation used (PUVA therapy and photodynamic therapy). Therapeutic methods using light energy are classified based on the radiation range used. Currently, UV phototherapy is distinguished, using UVA or UVB radiation, and photodynamic therapy (PDT), which uses radiation oscillating in the range of 350-700 nm.

Due to its immunosuppressive and antiproliferative effects, UV phototherapy is used to treat dermatological diseases such as psoriasis, vitiligo and atopic dermatitis. PUVA therapy uses the synergistic effect of ultraviolet radiation (UVA) and compounds with photosensitizing action (8-methoxypsolaren, 5-methoxypsolaren). In addition, monotherapy with ultraviolet radiation A1 (UVA1), broad-band UVB (BB-UVB) and narrow-band UVB (NB-UVB) are used.

Photodynamic therapy, apart from conventional treatment methods, is a modern and non-invasive alternative used both in the diagnosis and treatment of diseases of various etiologies. In 90% of cases, PDT is used to treat dermatological diseases such as acne vulgaris or psoriasis, allowing us to avoid invasive surgical intervention. Selective cytotoxic activity towards malignant tumor cells means that photodynamic therapy is also successfully used in the oncological treatment. The great progress made in the development of innovative photosensitive substances as well as new radiation sources expands the range of applicability of photodynamic therapy.

The aim of the study is to present the current forms of phototherapy by describing the mechanism of their action, application and the possibility of adverse effects.

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Articles in this issue

DOI: https://doi.org/10.2478/ahem-2021-0010 | Journal eISSN: 1732-2693

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Language: English, Polish

Page range: 873 - 888

Submitted on: May 27, 2020

Accepted on: Jun 25, 2021

Published on: Dec 27, 2021

Published by: Hirszfeld Institute of Immunology and Experimental Therapy

In partnership with: Paradigm Publishing Services

Publication frequency: 1 issue per year

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Related subjects:

Microbiology and virology,

Medicine,

Basic medical science,

Immunology

© 2021 Klaudia Banach, Marta Karkoszka, Dorota Wrześniok, published by Hirszfeld Institute of Immunology and Experimental Therapy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Volume 75 (2021): Issue 1 (January 2021)