Have a personal or library account? Click to login

Manifestation of Langerhans cell histiocytosis in the oral cavity: The authors’ experience

Open Access
|Jan 2022

Figures & Tables

Figure 1.

A 4-year-old patient. Premature loss of incisors and first maxillary and mandibular molars, generalised decrease in the translucency of the alveolar maxillary and mandibular bone with pronounced bone atrophy in the region of right mandibular cuspid and second mandibular molars, as well as root resorption of second mandibular molars
A 4-year-old patient. Premature loss of incisors and first maxillary and mandibular molars, generalised decrease in the translucency of the alveolar maxillary and mandibular bone with pronounced bone atrophy in the region of right mandibular cuspid and second mandibular molars, as well as root resorption of second mandibular molars

Figure 2.

A 10-month-year-old patient. Alveolar mandible expansion in the region of teeth 81-83 in the single-system LCH. Image of oral cavity lesions on computed tomography before treatment (a), 6 months after the start of treatment (b) and after completion of the therapy (c)
A 10-month-year-old patient. Alveolar mandible expansion in the region of teeth 81-83 in the single-system LCH. Image of oral cavity lesions on computed tomography before treatment (a), 6 months after the start of treatment (b) and after completion of the therapy (c)

Figure 3.

A 1,5 -year -old patient. Ulcer-like palatal lesions in the region of molars in the multi-system LCH
A 1,5 -year -old patient. Ulcer-like palatal lesions in the region of molars in the multi-system LCH

Characteristics of patients with Langerhans cell histiocytosis included in the study

Parameters Total study group single-system LCH form
multi-system
n/%
Total43/100%34/79.1 9/20.9
Sexmale25/58.1%19 6
female19/41.9%15 3
Age≤3 years18/41.9%12 6
>3–10 years13/30.2%11 2
≥10 years12/27.9%11 1
Systembones38/88.4%31 7
skin11/25.6%3 8
lungs5/11.6%0 5
pituitary gland4/9.3%0 4
neck lymph nodes2/4.6%0 2
liver1/2.3%0 1

Clinical and radiological symptoms in patients diagnosed with LCH

Patient no.Age at LCH diagnosis in years (age at the onset of oral lesions)SexDiagnosed form of LCHClinical symptoms of stomatognathic systemRadiological symptomsOther organs/systems, symptoms
Clinical pictureLocation
10.33femaleM-Sthird degree loose mandibular teeth, vivid red gingiva, bleeding on compressionalveolar part of the mandibleosteolytic bone lesionsskin, bones lungs, diabetes insipidus
20.87maleS-S bonealveolar mandible expansion in the region of teeth 81–83unilateral mandibleosteolytic right mandibular lesionno other symptoms
31.01maleS-S skingingivitis, loosening of teeth 71, 72, 81gingivanonetypical skin lesions on the chest
41.15maleM-Sgingivitis, tooth looseningpalatenonepapular lesions on the skin, exophthalmos, liver
51.44femaleM-Sulcer-like palatal lesions in the region of molars, root exposure and loosening of teeth 74, 75bilaterally involved palate in the region of molars and the alveolar part of the mandiblenoneskull bones, orbit, lungs
62.16maleM-Speriodontal destruction, exposed bifurcation of the first primary maxillary and mandibular molarsmaxilla and mandibleosteolytic lesions in the region of roots of first primary molarsskin lesions on the head, abdomen and back, liver infiltration
74.16femaleM-Smandibular expansion in the region of tooth 46 with gingival thickening and reddening in this regionUnilaterally involved mandible in the region of right molarsosteolytic lesions in the region of permanent molars and second primary molars, resorption of distal root of tooth 85, partial resorption of tooth bud 45neck lymph nodes, mediastinum, orbital tumour, skull bones, non-specific lesions in the lungs, liver
Language: English
Page range: 933 - 938
Submitted on: Aug 19, 2020
Accepted on: Apr 1, 2021
Published on: Jan 17, 2022
Published by: Hirszfeld Institute of Immunology and Experimental Therapy
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2022 Anna Matosek-Rutkowska, Monika Kuriata, Dorota Olczak-Kowalczyk, Ewa Krasuska-Sławińska, published by Hirszfeld Institute of Immunology and Experimental Therapy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.