Figure 1.
Figure 2.
Figure 3.
Characteristics of patients with Langerhans cell histiocytosis included in the study
| Parameters | Total study group single-system | LCH form | |||
|---|---|---|---|---|---|
| multi-system | |||||
| n/% | |||||
| Total | 43/100% | 34/79.1 | 9/20.9 | ||
| Sex | male | 25/58.1% | 19 | 6 | |
| female | 19/41.9% | 15 | 3 | ||
| Age | ≤3 years | 18/41.9% | 12 | 6 | |
| >3–10 years | 13/30.2% | 11 | 2 | ||
| ≥10 years | 12/27.9% | 11 | 1 | ||
| System | bones | 38/88.4% | 31 | 7 | |
| skin | 11/25.6% | 3 | 8 | ||
| lungs | 5/11.6% | 0 | 5 | ||
| pituitary gland | 4/9.3% | 0 | 4 | ||
| neck lymph nodes | 2/4.6% | 0 | 2 | ||
| liver | 1/2.3% | 0 | 1 |
Clinical and radiological symptoms in patients diagnosed with LCH
| Patient no. | Age at LCH diagnosis in years (age at the onset of oral lesions) | Sex | Diagnosed form of LCH | Clinical symptoms of stomatognathic system | Radiological symptoms | Other organs/systems, symptoms | |
|---|---|---|---|---|---|---|---|
| Clinical picture | Location | ||||||
| 1 | 0.33 | female | M-S | third degree loose mandibular teeth, vivid red gingiva, bleeding on compression | alveolar part of the mandible | osteolytic bone lesions | skin, bones lungs, diabetes insipidus |
| 2 | 0.87 | male | S-S bone | alveolar mandible expansion in the region of teeth 81–83 | unilateral mandible | osteolytic right mandibular lesion | no other symptoms |
| 3 | 1.01 | male | S-S skin | gingivitis, loosening of teeth 71, 72, 81 | gingiva | none | typical skin lesions on the chest |
| 4 | 1.15 | male | M-S | gingivitis, tooth loosening | palate | none | papular lesions on the skin, exophthalmos, liver |
| 5 | 1.44 | female | M-S | ulcer-like palatal lesions in the region of molars, root exposure and loosening of teeth 74, 75 | bilaterally involved palate in the region of molars and the alveolar part of the mandible | none | skull bones, orbit, lungs |
| 6 | 2.16 | male | M-S | periodontal destruction, exposed bifurcation of the first primary maxillary and mandibular molars | maxilla and mandible | osteolytic lesions in the region of roots of first primary molars | skin lesions on the head, abdomen and back, liver infiltration |
| 7 | 4.16 | female | M-S | mandibular expansion in the region of tooth 46 with gingival thickening and reddening in this region | Unilaterally involved mandible in the region of right molars | osteolytic lesions in the region of permanent molars and second primary molars, resorption of distal root of tooth 85, partial resorption of tooth bud 45 | neck lymph nodes, mediastinum, orbital tumour, skull bones, non-specific lesions in the lungs, liver |