Effect of cisplatin on lipid peroxidation in the whole blood and plasma of female rats

Figures & Tables

Concentration of malondialdehyde (nmol/ml)
	Baseline without treatment	After cisplatin action
Whole blood	6.62 ± 0.32	16.30 ± 0.70^*
Blood plasma	4.62 ± 0.22	7.31 ± 0.25^*
Activity of catalase enzyme in μmol of H₂O₂/mg protein min
Blood plasma	517.00 ± 8.50	233.00 ± 4.60^*

Lipid peroxidation products	Isopropyl alcohol phase
	Whole blood		Blood plasma
	Baseline without treatment	After cisplatin action	Baseline without treatment	After cisplatin action
Unsaturated fatty acids	33.05 ± 0.58	56.00 ± 2.40^*	22.00 ± 1.30	27.75 ± 0.23^*
Conjugated dienes	9.00 ± 0.20	17.38 ± 0.34^*	6.88 ± 0.25	8.70 ± 0.31^*
Conjugated trienes	7.58 ± 0.14	12.10 ± 0.30^*	3.54 ± 0.05	4.40 ± 0.20^*

Lipid peroxidation products	Heptane phase
	Whole blood		Blood plasma
	Baseline without treatment	After cisplatin action	Baseline without treatment	After cisplatin action
Unsaturated fatty acids	41.00 ± 1.64	45.00 ± 1.15	29.27 ± 1.20	27.41 ± 0.78
Conjugated dienes	4.52 ± 0.13	7.15 ± 0.10^*	6.44 ± 0.35	8.84 ± 0.14^*
Conjugated trienes	1.63 ± 0.10	3.27 ± 0.16^*	2.45 ± 0.15	4.00 ± 0.11^*

Oxidation index	Phases of lipid peroxidation products	Whole blood		Blood plasma
Oxidation index	Phases of lipid peroxidation products	Baseline without treatment	After cisplatin action	Baseline without treatment	After cisplatin action
For conjugated dienes (D₂₃₂/D₂₂₀)	Heptane phase	0.110	0.158	0.220	0.323
For conjugated dienes (D₂₃₂/D₂₂₀)	Isopropyl alcohol phase	0.272	0.310	0.313	0.314
For conjugated trienes (D₂₇₈/D₂₂₀)	Heptane phase	0.040	0.073	0.084	0.146
For conjugated trienes (D₂₇₈/D₂₂₀)	Isopropyl alcohol phase	0.230	0.216	0.161	0.159