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In vitro mechanism of luteolin suppresses enhanced endothelial permeability Cover

In vitro mechanism of luteolin suppresses enhanced endothelial permeability

European Pharmaceutical Journal
Volume 71 (2024): Issue 2 (December 2024)
By: ,  ,  ,   and    
Open Access
|Sep 2024
Figures & tables

Figures & Tables

Figure 1.

Chemical Structure of Luteolin.

Table 1.

In Vitro Vascular Permeability Assay Test: Mean of Permeability Index.

GroupMean ±S.E.M.Suppression (%)
Basal Cells--
Negative Control44.32 ±4.803-
Positive Control2.638 ±3.089***94.05
Luteolin (5 μM)13.62 ±3.763***69.27
Luteolin (10 μM)5.690 ±4.210***87.16
Luteolin (25 μM)0.8780 ±3.763***98.02

*** P < 0.001 significantly different from the negative control

Table 2.

Protein Kinase C Assay Test: Mean of Protein Kinase C Activity.

GroupMean ±S.E.M.Suppression (%)
Basal Cells0.03747 ±0.002667-
Negative Control0.04980 ±0.002458-
Positive Control0.03693 ±0.001637**104.38
Luteolin (5 μM)0.03817 ±0.001506*94.32
Luteolin (10 μM)0.03550 ±0.001646**115.98
Luteolin (25 μM)0.03437 ±0.001713**125.14

* P < 0.05 significantly different from the negative control

** P < 0.01 significantly different from the negative control

Table 3.

Intracellular Calcium Concentration Determination Test: Mean of Intracellular Calcium Concentration.

GroupMean ±S.E.M.Suppression (%)
Basal Cells360.6 ±11.85-
Negative Control502.4 ±22.05-
Positive Control412.2 ±17.15*63.61
Luteolin (5 μM)439.4 ±12.4344.43
Luteolin (10 μM)373.5 ±13.48**90.90
Luteolin (25 μM)354.7 ±16.06***104.16

* P < 0.05 significantly different from the negative control

** P < 0.01 significantly different from the negative control

*** P < 0.001 significantly different from the negative control

DOI: https://doi.org/10.2478/afpuc-2024-0010 | Journal eISSN: 2453-6725 (formerly 1338-6786) | Journal ISSN: 0301-2298
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Language: English
Page range: 1 - 6
Submitted on: Jun 25, 2024
Accepted on: Aug 7, 2024
Published on: Sep 26, 2024
Published by: Comenius University in Bratislava, Faculty of Pharmacy
In partnership with: Paradigm Publishing Services
Keywords:
Luteolin,
Endothelial Permeability,
Protein Kinase C,
Intracellular Calcium
Related subjects:
Pharmacy,
Pharmacy, other

© 2024 S.C Shuit, T.Y Wong, M.S Omar Fauzee, A Zuraini, M.N Somchit, published by Comenius University in Bratislava, Faculty of Pharmacy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Volume 71 (2024): Issue 2 (December 2024)
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