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A Multiple Unit Abuse-deterrent Dosage Form Based on Sodium Alginate Cover

A Multiple Unit Abuse-deterrent Dosage Form Based on Sodium Alginate

European Pharmaceutical Journal
Volume 70 (2023): Issue s1 (December 2023)
By: M. Papadakos,  M. Špaglová,  M. Čuchorová and  M. Hanko  
Open Access
|Sep 2023

Figures & Tables

Figure 1.

Hot dried Ca2+-alginate microcapsules at 77× and 100× magnification.
Hot dried Ca2+-alginate microcapsules at 77× and 100× magnification.

Figure 2.

Ca2+-alginate microcapsules taken after 24 h in artificial intestinal fluid pH 6.8 (a1 – hot dried, a2 – freeze-dried), artificial gastric fluid pH 1.2 (b1 – hot dried, b2 – freeze-dried), and artificial gastric fluid with ethanol 40% (w/w) (c1 – hot dried, c2 – freeze-dried)
Ca2+-alginate microcapsules taken after 24 h in artificial intestinal fluid pH 6.8 (a1 – hot dried, a2 – freeze-dried), artificial gastric fluid pH 1.2 (b1 – hot dried, b2 – freeze-dried), and artificial gastric fluid with ethanol 40% (w/w) (c1 – hot dried, c2 – freeze-dried)

Figure 3.

The swelling ability of Ca2+-alginate microcapsules in artificial gastric fluid (pH 1.2), artificial gastric fluid with 40% (w/w) ethanol (pH 1.2 + EtOH), and artificial intestinal fluid (pH 6.8).
The swelling ability of Ca2+-alginate microcapsules in artificial gastric fluid (pH 1.2), artificial gastric fluid with 40% (w/w) ethanol (pH 1.2 + EtOH), and artificial intestinal fluid (pH 6.8).
DOI: https://doi.org/10.2478/afpuc-2023-0020 | Journal eISSN: 2453-6725
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Language: English
Page range: 75 - 79
Submitted on: Apr 14, 2018
|
Accepted on: Jun 1, 2018
|
Published on: Sep 15, 2023
Published by: Comenius University in Bratislava, Faculty of Pharmacy
In partnership with: Paradigm Publishing Services
Publication frequency: 2 issues per year
Keywords:
Multiple unit dosage form,
Abuse deterrent dosage form,
Microcapsules,
Microbeads,
Sodium alginate
Related subjects:
Pharmacy,
Pharmacy, other

© 2023 M. Papadakos, M. Špaglová, M. Čuchorová, M. Hanko, published by Comenius University in Bratislava, Faculty of Pharmacy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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