Figure 1.
Figure 2.
Composition of ketoprofen floating in situ gel_
| Formulation code | Ketoprofen (g) | Sodium alginate (%) | Gellan gum (%) | HPMC K100M (%) | Trisodium citrate (%) | CaCl2 (%) | CaCO3 paraben (%) | Methyl (%) | Propyl paraben saccharine (%) | Sodium (%) | Distilled water (q. s) (ml) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| F1 | 2 | 0.5 | - | - | 0.25 | 0.16 | 0.750 | 0.18 | 0.02 | 0.2 | 100 |
| F2 | 2 | 1 | - | - | 0.25 | 0.16 | 0.750 | 0.18 | 0.02 | 0.2 | 100 |
| F3 | 2 | 1.5 | - | - | 0.25 | 0.16 | 0.750 | 0.18 | 0.02 | 0.2 | 100 |
| F4 | 2 | - | 0.150 | - | 0.25 | 0.16 | 0.750 | 0.18 | 0.02 | 0.2 | 100 |
| F5 | 2 | - | 0.175 | - | 0.25 | 0.16 | 0.750 | 0.18 | 0.02 | 0.2 | 100 |
| F6 | 2 | - | 0.150 | 0.2 | 0.25 | 0.16 | 0.750 | 0.18 | 0.02 | 0.2 | 100 |
| F7 | 2 | - | 0.175 | 0.2 | 0.25 | 0.16 | 0.750 | 0.18 | 0.02 | 0.2 | 100 |
In vitro buoyancy study of prepared in situ gel of ketoprofen_
| Formulation code | Floating lag time (s) | Total floating time (h) |
|---|---|---|
| F1 | 45 | >24 |
| F2 | 30 | >24 |
| F3 | 24 | >24 |
| F4 | 69 | >24 |
| F5 | 64 | >24 |
| F6 | 37 | >24 |
| F7 | 22 | >24 |
Physical appearance, pH, and gelling capacity of prepared in situ gel_
| Formulation code | Physical appearance | pH* | Gelling capacity |
|---|---|---|---|
| F1 | Light yellow | 7.61 ± 0.03 | ++ |
| F2 | Light yellow | 6.98 ± 0.01 | ++ |
| F3 | Light yellow | 6.94 ± 0.04 | +++ |
| F4 | Milky white | 6.95 ± 0.05 | ++ |
| F5 | Milky white | 7.32 ± 0.02 | +++ |
| F6 | Milky white | 6.89 ± 0.03 | +++ |
| F7 | Milky white | 7.34 ± 0.01 | +++ |
Drug content, gel strength, density of prepared in situ gel of ketoprofen_
| Formulation code | Drug content (%)* | Gel strength (s)* | Density (g/cm3)* |
|---|---|---|---|
| F1 | 83.45 ± 0.03 | 30.1 ± 0.22 | 0.575 ± 0.0102 |
| F2 | 90.50 ± 0.53 | 36.14 ± 0.03 | 0.615 ± 0.0021 |
| F3 | 92.42 ± 0.02 | 45.21 ± 0.51 | 0.632 ± 0.0062 |
| F4 | 86.71 ± 0.31 | 21.21 ± 0.04 | 0.522 ± 0.0028 |
| F5 | 93.65 ± 0.31 | 27.54 ± 0.02 | 0.550 ± 0.0025 |
| F6 | 90.09 ± 0.72 | 73.65 ± 0.31 | 0.613 ± 0.0166 |
| F7 | 95.53 ± 0.01 | 78.65 ± 0.01 | 0.616 ± 0.0025 |
Viscosity of prepared in situ gel of ketoprofen_
| Formulation code | Viscosity (cps)* |
|---|---|
| F1 | 209.0 ± 0.2 |
| F2 | 225.9 ± 0.03 |
| F3 | 239.7 ± 0.32 |
| F4 | 133.8 ± 0.07 |
| F5 | 138.9 ± 0.51 |
| F6 | 153.7 ± 0.03 |
| F7 | 155.3 ± 0.06 |