Formulation and Evaluation of Gastroretentive In Situ Gelling System of Ketoprofen

Formulation code	Ketoprofen (g)	Sodium alginate (%)	Gellan gum (%)	HPMC K100M (%)	Trisodium citrate (%)	CaCl₂ (%)	CaCO₃ paraben (%)	Methyl (%)	Propyl paraben saccharine (%)	Sodium (%)	Distilled water (q. s) (ml)
F1	2	0.5	-	-	0.25	0.16	0.750	0.18	0.02	0.2	100
F2	2	1	-	-	0.25	0.16	0.750	0.18	0.02	0.2	100
F3	2	1.5	-	-	0.25	0.16	0.750	0.18	0.02	0.2	100
F4	2	-	0.150	-	0.25	0.16	0.750	0.18	0.02	0.2	100
F5	2	-	0.175	-	0.25	0.16	0.750	0.18	0.02	0.2	100
F6	2	-	0.150	0.2	0.25	0.16	0.750	0.18	0.02	0.2	100
F7	2	-	0.175	0.2	0.25	0.16	0.750	0.18	0.02	0.2	100

Table 2.

Physical appearance, pH, and gelling capacity of prepared in situ gel.

Formulation code	Physical appearance	pH^*	Gelling capacity
F1	Light yellow	7.61 ± 0.03	++
F2	Light yellow	6.98 ± 0.01	++
F3	Light yellow	6.94 ± 0.04	+++
F4	Milky white	6.95 ± 0.05	++
F5	Milky white	7.32 ± 0.02	+++
F6	Milky white	6.89 ± 0.03	+++
F7	Milky white	7.34 ± 0.01	+++

* Mean and SD of n determinations; n = 3

SD: standard deviation

+: Gels after a few seconds and is rapidly dispersed

++: Gels immediately and the formed gel remained buoyant for 12 h

+++: Gels immediately and the formed gel remained buoyant for >12 h

Table 3.

Viscosity of prepared in situ gel of ketoprofen.

Formulation code	Viscosity (cps)^*
F1	209.0 ± 0.2
F2	225.9 ± 0.03
F3	239.7 ± 0.32
F4	133.8 ± 0.07
F5	138.9 ± 0.51
F6	153.7 ± 0.03
F7	155.3 ± 0.06

* Mean and SD of n determinations; n = 3

SD: standard deviation

Table 4.

In vitro buoyancy study of prepared in situ gel of ketoprofen.

Formulation code	Floating lag time (s)	Total floating time (h)
F1	45	>24
F2	30	>24
F3	24	>24
F4	69	>24
F5	64	>24
F6	37	>24
F7	22	>24

In vitro buoyancy study of formulation F7.

Table 5.

Drug content, gel strength, density of prepared in situ gel of ketoprofen.

Formulation code	Drug content (%)^*	Gel strength (s)^*	Density (g/cm³)^*
F1	83.45 ± 0.03	30.1 ± 0.22	0.575 ± 0.0102
F2	90.50 ± 0.53	36.14 ± 0.03	0.615 ± 0.0021
F3	92.42 ± 0.02	45.21 ± 0.51	0.632 ± 0.0062
F4	86.71 ± 0.31	21.21 ± 0.04	0.522 ± 0.0028
F5	93.65 ± 0.31	27.54 ± 0.02	0.550 ± 0.0025
F6	90.09 ± 0.72	73.65 ± 0.31	0.613 ± 0.0166
F7	95.53 ± 0.01	78.65 ± 0.01	0.616 ± 0.0025

* Mean and SD of n determinations; n = 3

SD: standard deviation

In vitro release profile of ketoprofen in situ gel formulations.

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DOI: https://doi.org/10.2478/afpuc-2023-0018 | Journal eISSN: 2453-6725 (formerly 1338-6786) | Journal ISSN: 0301-2298

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Language: English

Page range: 10 - 19

Submitted on: May 24, 2022

Accepted on: Aug 28, 2023

Published on: Oct 7, 2023

Published by: Comenius University in Bratislava, Faculty of Pharmacy

In partnership with: Paradigm Publishing Services

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© 2023 AR. Shabaraya, T. T Ashwini, K. Vineetha, published by Comenius University in Bratislava, Faculty of Pharmacy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Volume 70 (2023): Issue 2 (December 2023)

Formulation and Evaluation of Gastroretentive In Situ Gelling System of Ketoprofen

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Table 1.

Table 2.

Table 3.

Table 4.

Figure 1.

Table 5.

Figure 2.

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