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Formulation Options for Mucoadhesive Dosage Forms for Use in the Oral Cavity Cover

Formulation Options for Mucoadhesive Dosage Forms for Use in the Oral Cavity

Open Access
|Sep 2023

Figures & Tables

Mucoadhesive polymers used in mucoadhesive buccal film formulations identified in the literaturea

Mucoadhesive polymerApplication in mucoadhesive buccal films – APIUsed plasticizer(s)
Methyl cellulose (MC)Cetylpyridinium chloride, carvedilol, omeprazole, nebivololPropylene glycol, PEG-400
Ethyl cellulose (EC)Allantoin, fluticasone propionate, propranolol hydrochloride, ketorolac tromethamine, resveratrol, propranolol hydrochloride & nifedipinePEG-400, triethyl citrate, propylene glycol, PEG-800, PEG-600, castor oil, glycerol, dibutylphthalate
Hydroxypropyl methyl cellulose (HPMC)Cetylpyridinium chloride, carvedilol, omeprazole, allantoin, fluticasone propionate, propranolol hydrochloride, ketorolac tromethamine, enalapril maleate, glibenclamide, cetirizine dihydrochloride, glimepiride, nitrendipine, clotrimazole, lidocaine hydrochloride, ibuprofen, ondansetron hydrochloride, meloxicam, prednisolone, rizatriptan benzoate, lycopene, risedronate sodium, clinidipine, furosemide, domperidone, catechin, lidocaine hydrochloride & benzydamine hydrochloride & N-acetyl-l-cysteine, nebivolol, nicotine, piroxicamPropylene glycol, PEG-400, triethyl citrate, PEG-800, PEG-600, castor oil glycerol, PEG-3350, triethanolamine, sorbitol, PEG-200
Hydroxypropyl cellulose (HPC)Ketorolac tromethamine, resveratrol, nitrendipine, clotrimazole, lidocaine hydrochloride, diltiazem hydrochloride, indomethacin, lycopenePropylene glycol, PEG-400, glycerol, PEG-3350
Hydroxyethyl cellulose (HEC)Cetylpyridinium chloride, allantoin, propranolol hydrochloride, meloxicam, moxifloxacin hydrochloride & clove oil, acyclovir, hyaluronic acid, nebivololPEG-400, triethyl citrate, PEG-600, castor oil, glycerol propylene glycol
Carboxymethyl cellulose (CMC, SCMC)Allantoin, fluticasone propionate, ketorolac tromethamine, enalapril maleate, nitrendipine, ibuprofen, meloxicam, diltiazem hydrochloride, lysozyme, rizatriptan benzoate, ciprofloxacin, glipizide, carvedilol, lycopene, lidocaine hydrochloride & benzydamine hydrochloride & N-acetyl-L-cysteine, simvastatin, lysozyme & epidermal growth factor, imiquimodPEG-400, triethyl citrate, propylene glycol, PEG-800, glycerol, triethanolamine, sorbitol
Xyloglucan (XYL)Rizatriptan benzoateGlycerol
Polycarbophil (PCP)Lidocaine hydrochloride, ibuprofenGlycerol, PEG-3350, triethanolamine, propylene glycol
Polyethylene oxide (PEO)Lidocaine hydrochloride, streptomycin & diclofenac, rizatriptan benzoate, domperidonePEG-3350, glycerol
Poloxamer (POL)Glimepiride, ibuprofen, methylene bluePropylene glycol, PEG-600, glycerol
Polyacrylic acid (PAA)Carvedilol, fluticasone propionate, ketorolac, tromethamine, glimepiride, nitrendipine, clotrimazole, ibuprofen, rizatriptan benzoate, atenolol, prednisolone, lycopene, piroxicam, glipizidePropylene glycol, PEG-800, glycerol, triethanolamine, PEG-400
Polymethacrylic acid (PMA)Carvedilol, glibenclamide, glimepiride, clotrimazole, ibuprofen, acyclovir, penciclovir, almotriptan, prednisolone, glipizide, rizatriptan benzoatePropylene glycol, triethanolamine, PEG-400, PEG-200
Chitosan (CHT)Cetylpyridinium chloride, fluticasone propionate, propranolol hydrochloride & nifedipine, propranolol hydrochloride, ondansetron hydrochloride, tenoxicam, tramadol, progesterone, insulin, lidocaine hydrochloride, clotrimazole, paracetamol, metronidazole, miconazole nitrate, risedronate sodium, lidocaine hydrochloride & benzydamine hydrochloride & N-acetyl-l-cysteine, ropinirole hydrochloride, piroxicamPropylene glycol, PEG-800, glycerol, dibutylphthalate, PEG-400, sorbitol
Polyvinyl alcohol (PVA)Cetylpyridinium chloride, nitrendipine, meloxicam, methylene blue, benznidazole, dexamethasone, paracetamol, rizatriptan benzoate, carvedilol, propranolol hydrochloride, allantoin, propranololGlycerol, PEG-400, propylene glycol, sorbitol, triethyl citrate, PEG-600, castor oil
Polyvinylpyrrolidone (PVP)Hydrochloride, ketorolac tromethamine, enalapril maleate, nitrendipine, ibuprofen, methylene blue, penciclovir, ondansetron hydrochloride, tenoxicam, tramadol, progesterone, lysine clonixinate, carvedilol, lycopene, simvastatin, ropinirole hydrochloride, epidermal growth factor & lysozymeGlycerol, triethanolamine, propylene glycol
Gelatin (GEL)Ondansetron hydrochloride, lysozyme, progesterone, propranolol hydrochloride, lidocaine hydrochlorideGlycerol
Sodium alginate (SA)Cetylpyridinium chloride, omeprazole, cetirizine dihydrochloride, nitrendipine, ciprofloxacin, atenolol, nicotine, carvedilol, lycopenePEG-400, glycerol, propylene glycol
Gellan gum (GLG)Moxifloxacin hydrochloride & clove oil, triamcinolone, acetonide, fluconazoleGlycerol, propylene glycol
Guar gum (GUG)Lysine clonixinate, zolmitriptan succinate, α-casozepinePropylene glycol, glycerol
Xanthan gum (XG)DomperidoneNot stated
Carrageenan (CRG)Omeprazole, streptomycin & diclofenac, ibuprofen, miconazole nitratePEG-400, glycerol, PEG-600, propylene glycol
Pectin (PCT)Meloxicam, clotrimazole, paracetamol, metronidazole, triamcinolone acetonidePEG-400, glycerol propylene glycol
Hyaluronic acid (HA)Ondansetron hydrochloride, hyaluronic acid, benzydamine hydrochloridePEG-400, glycerol
Rice starch (RS)Lidocaine hydrochloride, diclofenac sodium, paracetamolGlycerol, PEG-400, propylene glycol, sorbitol
Tapioca starch (TS)Lidocaine hydrochlorideGlycerol
Arrowroot starch (AS)GlipizideGlycerol
Agarose (AGR)Zolmitriptan succinateGlycerol
Pullulan (PLL)Enalapril maleate, yonkenafil, methylene blueGlycerol, propylene glycol
Maltodextrin (MAL)Methylene bluePropylene glycol

Various techniques used to produce mucoadhesive buccal films (Shipp et al_, 2022)_

MethodAdvantagesDisadvantages
Solvent castingSimple, reproducible, and established process; industrial solvent casting offers better control over film thickness and polymer concentrationsDrug recrystallization after production; changes in film mechanical properties due to plasticizing small molecules; difficult to achieve dose uniformity; potential for entrapped air bubbles; lack of control over film thickness and polymer concentration
Hot melt extrusionSolventless, continuous process, with fewer operations and better content uniformity than solvent casting; ability to incorporate poorly soluble drugsDrug recrystallization after production; swelling of film after leaving the die; limited and specialist excipients required; agglomeration of ingredients; weight variations due to improper flow, problems with chemical stability; not suitable for thermosensitive drugs
Inkjet printingRecrystallization prevented by depositing API onto the film, rather than building API in; mechanical properties of drug-free film retained; able to precisely deposit small volumes of liquids; ability to personalize treatmentRequires another process to make the film deposit drug substances onto; primarily applicable where a low dose of active substance is required; nozzle blockage may lead to inaccurate printed dosages
3D printingContinuous process capability, with personalized treatment; compartmentalization can prevent incompatible excipient interactions; increases precision of manufacture; thermosensitive drugs can be used with high loading capacityFDM (fused deposition modelling) filament production by HME (hot melt extrusion) has the same challenges; drying in SSE (semi-solid extrusion) may alter the dimensions of printed objects; only small-scale, nonreproducible manufacture possible; barriers to clinical adoption for this emerging technology
Language: English
Page range: 44 - 51
Submitted on: Jun 22, 2023
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Accepted on: Jun 23, 2023
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Published on: Sep 13, 2023
In partnership with: Paradigm Publishing Services
Publication frequency: 2 issues per year
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© 2023 V. Šimunková, E. Tichý, M. Špaglová, M. Potúčková, published by Comenius University in Bratislava, Faculty of Pharmacy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.