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N-glycans Profiling in Pilocarpine Induced Status Epilepticus in Immature Rats Cover

N-glycans Profiling in Pilocarpine Induced Status Epilepticus in Immature Rats

European Pharmaceutical Journal
Volume 69 (2022): Issue 2 (August 2022)
By: S. Kapoor,  M. Nemcovic,  J. Folbergrova,  D. Kala,  J. Svoboda,  J. Otahal and  Z. Brnoliakova  
Open Access
|Aug 2022

Figures & Tables

Figure 1

The relative intensities of N-glycans in the experimental model of lithium pilocarpine (Li-Pilo) induced status epilepticus (SE) in blood sera in immature rats. N-glycans were assorted according to (a) sialylation and non-sialylation; (b) their glycan type. Explanatory notes: High-Man – high-mannose type of N-glycan; C-Bi – complex bi-antennary; C-Bi-Fuc – complex bi-antennary with Fucose; C-Tri – complex tri-antennary; C-Tri-Fuc – complex tri-antennary with Fucose; C-Tetra – complex tetra-antennary; C-Tetra-Fuc – complex tetra-antennary with Fucose; Hybrid – hybrid type of N-glycan. Data were evaluated using GraphPad Software. Unpaired t-test with two tailed analysis was used to evaluate the difference among the experimental groups. The statistically significant difference are marked as * for p < 0.05 and ** for p < 0.01. Data were expressed as means ± SEM.
The relative intensities of N-glycans in the experimental model of lithium pilocarpine (Li-Pilo) induced status epilepticus (SE) in blood sera in immature rats. N-glycans were assorted according to (a) sialylation and non-sialylation; (b) their glycan type. Explanatory notes: High-Man – high-mannose type of N-glycan; C-Bi – complex bi-antennary; C-Bi-Fuc – complex bi-antennary with Fucose; C-Tri – complex tri-antennary; C-Tri-Fuc – complex tri-antennary with Fucose; C-Tetra – complex tetra-antennary; C-Tetra-Fuc – complex tetra-antennary with Fucose; Hybrid – hybrid type of N-glycan. Data were evaluated using GraphPad Software. Unpaired t-test with two tailed analysis was used to evaluate the difference among the experimental groups. The statistically significant difference are marked as * for p < 0.05 and ** for p < 0.01. Data were expressed as means ± SEM.

The list of detected N-glycans sorted according to their structural type_

Glycan typem/z
High-Man1579.8; 1783.5; 1988.1; 2192.2; 2396.4
C-Bi2227.4; 2431.5; 2736.8; 2792.7
C-Bi-Fuc1836.1; 2040.2; 2605.7; 2966.9
C-Tri3154.1; 3603.2
C-Tri-Fuc2081.2; 3328.1; 3777.4
C-Tetra3964.3
C-Tetra-Fuc4138.4
Hybrid2390.4
DOI: https://doi.org/10.2478/afpuc-2022-0011 | Journal eISSN: 2453-6725
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Language: English
Page range: 1 - 4
Submitted on: Feb 9, 2022
Accepted on: May 26, 2022
Published on: Aug 11, 2022
Published by: Comenius University in Bratislava, Faculty of Pharmacy
In partnership with: Paradigm Publishing Services
Publication frequency: 2 issues per year
Keywords:
N-glycans,
MALDI-TOF/MS,
Status epilepticus,
Sialic acid,
New-born rats
Related subjects:
Pharmacy,
Pharmacy, other

© 2022 S. Kapoor, M. Nemcovic, J. Folbergrova, D. Kala, J. Svoboda, J. Otahal, Z. Brnoliakova, published by Comenius University in Bratislava, Faculty of Pharmacy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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