Influence of Semax and Selank on the leukocyte counts of animals in conditions of “social” stress_
| Indicators (M ± m) | Control | „Social” stress | „Social” stress + Semax (100 mcg/kg/day) | „Social” stress + Selank (100 mcg/kg/day) |
|---|---|---|---|---|
| Experimental group (n = 10) | ||||
| Animals with an aggressive type of behaviour | ||||
| Total number of leukocytes, ×109/l | 11.7 ± 0.93 | 8.3 ± 0.82* | 12.5 ± 1.04## | 15.7 ± 1.24### |
| Eosinophils, % | 2.8 ± 0.33 | 2.0 ± 0.21* | 2.8 ± 0.24# | 2.4 ± 0.20 |
| Band neutrophils, % | 2.2 ± 0.23 | 3.4 ± 0.25** | 2.3 ± 0.30# | 2.1 ± 0.36# |
| Segmented neutrophils, % | 12.7 ± 1.59 | 26.7 ± 1.81*** | 13.3 ± 2.0### | 16.0 ± 2.10## |
| Lymphocytes,% | 81.5 ± 5.95 | 67.1 ± 4.27 | 80.8 ± 4.9 | 78.7 ± 4.87 |
| Monocytes, % | 0.83 ± 0.15 | 0.71 ± 0.10 | 0.81 ± 0.10 | 0.86 ± 0.11 |
| Animals with a submissive type of behaviour | ||||
| Total number of leukocytes, ×109/l | 11.7 ± 0.93 | 8.4 ± 0.77* | 11.6 ± 1.01# | 13.1 ± 0.58### |
| Eosinophils, % | 2.8 ± 0.33 | 1.6 ± 0.11## | 2.3 ± 0.31# | 2.1 ± 0.22# |
| Band neutrophils, % | 2.2 ± 0.23 | 4.1 ± 0.40** | 2.0 ± 0.24### | 2.1 ± 0.37## |
| Segmented neutrophils, % | 12.7 ± 1.59 | 27.1 ± 2.11*** | 16.4 ± 2.1## | 16.1 ± 2.57## |
| Lymphocytes,% | 81.5 ± 5.95 | 66.4 ± 4.77 | 78.5 ± 4.4 | 78.9 ± 4.87 |
| Monocytes, % | 0.83 ± 0.15 | 0.71 ± 0.10 | 0.82 ± 0.14 | 0.86 ± 0.11 |
The influence of Semax and Selank on the formation of DTH and DAT in conditions of “social” stress_
| Experimental groups (n = 10) | Index DTH, % | Titre of antibodies in DAT, log2 |
|---|---|---|
| Indicators (M ± m) | ||
| Animals with an aggressive type of behavior | ||
| Control | 30.83 ± 3.52 | 224.77 ± 23.27 |
| „Social” stress | 16.57 ± 1.75** | 40.46 ± 5.81*** |
| „Social” stress + Semax (100 mcg /kg/day) | 25.20 ± 2.46* | 152.60 ± 18.62### |
| „Social” stress + Selank(100 mcg /kg/day) | 30.38 ± 3.48## | 210.56 ± 22.54### |
| Animals with a submissive type of behavior | ||
| Control | 30.83 ± 3.52 | 224.77 ± 23.27 |
| „Social” stress | 20.78 ± 2.54* | 103.55 ± 11.64*** |
| „Social” stress + Semax (100 mcg /kg/day) | 27.40 ± 2.76 | 148.21 ± 18.81# |
| „Social” stress + Selank (100 mcg /kg/day) | 28.26 ± 2.66# | 231.19 ± 34.91## |
Influence of Semax and Selank on the phagocytic activity of neutrophils in conditions of “social” stress_
| Experimental groups (n = 10) | Phagocytic index | Phagocytic number, % |
|---|---|---|
| Indicators (M ± m) | ||
| Animals with an aggressive type of behaviour | ||
| Control | 17.7 ± 1.68 | 53.3 ± 3.66 |
| „Social” stress | 21.0 ± 1.85 | 74.3 ± 7.37* |
| „Social” stress + Semax (100 mcg /kg/day) | 16.8 ± 1.23 | 53.2 ± 4.63# |
| „Social” stress + Selank (100 mcg /kg/day) | 16.3 ± 1.87 | 57.6 ± 4.23 |
| Animals with a submissive type of behaviour | ||
| Control | 17.7 ± 1.68 | 53.3 ± 3.66 |
| „Social” stress | 22.9 ± 1.61* | 63.7 ± 4.73 |
| „Social” stress + Semax (100 mcg /kg/day) | 10.8 ± 1.30### | 44.6 ± 4.53# |
| „Social” stress + Selank (100 mcg /kg/day) | 18.4 ± 1.58 | 50.5 ± 4.65 |