Table 1
The composition of indomethacin suppositories (the mass for preparation of 14 supp.).
| Supp. 1 | Supp. 2 | Supp. 3 | Supp. 4 | Supp. 5 | Supp. 6 | |
|---|---|---|---|---|---|---|
| Indomethacin (g) | 1.4 | 1.4 | 1.4 | 1.4 | 1.4 | 1.4 |
| Polysorbate 80 (g) | - | 7.9 | - | - | 7.9 | - |
| Microemulsion (g) | - | - | 7.9 | - | - | 7.9 |
| Adeps base (g) | 28.0 | 18.7 | 18.7 | - | - | - |
| Macrogol base (g) | - | - | - | 33.1 | 23.9 | 23.9 |
Figure 1
The dissolution profiles of indomethacin from different suppository bases depending on the presence of the solubilizer (Polysorbate 80/ME).
Table 2
The comparison of indomethacin suppositories through physical parameters.
| Uniformity of mass (g) | Hardness (N) | Softening time (s) | |
|---|---|---|---|
| Adeps | 1.97 ± 0.01 | 76.3 ± 18,6 | 474.0 ± 8.5 |
| Adeps + Polysorbate 80 | 2.06 ± 0.02 | 54.3 ± 4.5 | 361.0 ± 80.6 |
| Adeps + ME | 1.93 ± 0.03 | 51.6 ± 10.6 | 261.0 ± 42.4 |
| Macrogol | 2.33 ± 0.07 | - | 2265.0 ±190.9 |
| Macrogol + Polysorbate 80 | 2.36 ± 0.02 | - | 1680.0 ± 84.9 |
[i] (-) not possible to evaluate, suppositories did not break but deformed