Nephroprotective Effect of Coenzyme Q10 alone and in Combination with N-acetylcysteine in Diabetic Nephropathy

Manojkumar S. Mahajan; Aman B. Upaganlawar; Chandrashekar D. Upasani

doi:10.2478/afpuc-2020-0020

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Nephroprotective Effect of Coenzyme Q10 alone and in Combination with N-acetylcysteine in Diabetic Nephropathy

European Pharmaceutical Journal

Volume 68 (2021): Issue 1 (January 2021)

By: Manojkumar S. Mahajan, Aman B. Upaganlawar and Chandrashekar D. Upasani

Open Access

|Jun 2021

Figures & Tables

Effect of CoQ10, NAC or their combination on a) serum urea, b) BUN and c) uric acid.

Effect of CoQ10, NAC or their combination on a) urine volume (mL/Day), b) urinary protein (mg/dL) and c) UAER (μg/min).

Effect of CoQ10, NAC or their combination on renal OS and anti-oxidant markers a) MDA, b) SOD, c) CAT and d) GSH.

Effect of CoQ10, NAC or their combination on MPO activity and NO in renal tissue_

Groups	MPO	NO
Groups	(U/g Tissue)	(μmol/g Tissue)
Control	8.00 ± 0.718	4.38 ± 0.567
STZ-NAD DN	27.28 ± 0.871^a	12.45 ± 0.776 ^a
CoQ10 (10 mg/kg)	16.63 ± 0.639^ab	6.36 ± 0.355^b
NAC (300 mg/kg)	17.27 ± 0.556^ab	7.23 ± 0.480^ab
CoQ10 + NAC	13.07 ± 0.582^abcd	4.68 ± 0.425^bd

Effect of CoQ10, NAC or their combination on body weight% and kidney to body weight ratio (mg/g)_

Groups	Body weight %		Kidney to Body Weight Ratio (mg/g)
Groups	Initial at Week 0	Final at Week 12	Kidney to Body Weight Ratio (mg/g)
Control	100.0 ± 0.368	145.2 ± 0.865^*	3.807 ± 0.041
STZ-NAD DN	100.0 ±1.389	87.5 ± 0.958^a*	7.504 ± 0.193 ^a
CoQ10 (10 mg/kg)	100.0 ±0.763	105.2 ± 1.122^ab*	5.490 ± 0.199^ab
NAC (300 mg/kg)	100.0 ±1.128	106.5 ± 0.467^ab*	5.201 ± 0.072^ab
CoQ10 + NAC	100.0 ±1.039	112.0 ± 1.217^abcd*	4.530 ± 0.126^abcd

Effect of CoQ10, NAC or their combination on blood glucose level (mg/dL) and HbA1C

Groups	Blood Glucose (mg/dL)		HbA_1C (%)
Groups	Initial at Week 0	Final at Week 12	HbA_1C (%)
Control	91.83 ± 2.937	91.0 ± 3.13	4.733 ± 0.084
STZ-NAD DN	499.0 ± 17.27^a	534.0 ± 24.28^a	9.05 ± 0.283 ^a
CoQ10 (10 mg/kg)	473.2 ± 17.35^a	413.5 ± 5.812^ab*	6.15 ± 0.080^ab
NAC (300 mg/kg)	480.0 ± 15.73^a	451.7 ± 11.8^ab	6.4 ± 0.085^ab
CoQ10 + NAC	477.7 ± 15.34^a	351.5 ± 12.03^abcd*	5.4 ± 0.171^abcd

Effect of CoQ10, NAC or their combination on serum total protein, albumin, creatinine and creatinine clearance_

Groups	Total Protein (g/dL)	Albumin (g/dL)	Creatinine (mg/dL)	Creatinine clearance (mL/min)
Control	7.55 ± 0.071	3.65 ± 0.042	0.426 ± 0.032	1.134 ± 0.088
STZ-NAD DN	4.88 ± 0.094^a	1.86 ± 0.114 ^a	2.7 ± 0.182 ^a	0.269 ± 0.030^ab
CoQ10 (10 mg/kg)	6.21 ± 0.149^ab	2.95 ± 0.117^ab	1.51 ± 0.110^ab	0.631 ± 0.039^ab
NAC (300 mg/kg)	5.93 ± 0.195^ab	2.56 ± 0.133^ab	1.55 ± 0.105^ab	0.608 ± 0.045^ab
CoQ10 + NAC	6.9 ± 0.063^abcd	3.05 ± 0.067^abd	1.05 ± 0.058^abcd	0.907 ± 0.039^abcd

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DOI: https://doi.org/10.2478/afpuc-2020-0020 | Journal eISSN: 2453-6725

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Language: English

Page range: 30 - 39

Submitted on: Nov 3, 2020

Accepted on: Mar 29, 2021

Published on: Jun 18, 2021

Published by: Comenius University in Bratislava, Faculty of Pharmacy

In partnership with: Paradigm Publishing Services

Publication frequency: 2 issues per year

Keywords:

Diabetic nephropathy,

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© 2021 Manojkumar S. Mahajan, Aman B. Upaganlawar, Chandrashekar D. Upasani, published by Comenius University in Bratislava, Faculty of Pharmacy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Volume 68 (2021): Issue 1 (January 2021)

Nephroprotective Effect of Coenzyme Q10 alone and in Combination with N-acetylcysteine in Diabetic Nephropathy

Figures & Tables

Figure 1

Figure 2

Figure 3

Effect of CoQ10, NAC or their combination on MPO activity and NO in renal tissue_

Effect of CoQ10, NAC or their combination on body weight% and kidney to body weight ratio (mg/g)_

Effect of CoQ10, NAC or their combination on blood glucose level (mg/dL) and HbA1C

Effect of CoQ10, NAC or their combination on serum total protein, albumin, creatinine and creatinine clearance_

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