Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Physical properties of metronidazole granules prepared with different diluents_
| Formulations with diluents | ||||||
|---|---|---|---|---|---|---|
| Parameters | I | II | III | IV | V | VI |
| Particle size (d50, μm) | 290.00 | 270.00 | 235.00 | 165.00 | 150.00 | 155.00 |
| Angle of repose (°) | 30.03 ± 0.20 | 29.63 ± 0.50 | 28.58 ± 1.87 | 30.25 ± 0.61 | 27.52 ± 0.32 | 28.27 ± 0.56 |
| Bulk density (g/cm3) | 0.55 ± 0.01 | 0.54 ± 0.02 | 0.48 ± 0.01 | 0.43 ± 0.03 | 0.43 ± 0.03 | 0.41 ± 0.01 |
| Tapped density (g/cm3) | 0.66 ± 0.02 | 0.67 ± 0.00 | 0.60 ± 0.01 | 0.62 ± 0.07 | 0.58 ± 0.01 | 0.56 ± 0.02 |
| True density (g/cm3) | 1.46 | 1.44 | 1.54 | 1.52 | 1.52 | 1.54 |
| Carr's Index (%) | 16.44 ± 0.32 | 18.86 ± 3.10 | 19.28 ± 0.33 | 30.95 ± 3.37 | 26.51 ± 2.92 | 25.79 ± 1.83 |
| Hausner's ratio | 1.20 ± 0.00 | 1.23 ± 0.05 | 1.24 ± 0.01 | 1.45 ± 0.07 | 1.36 ± 0.05 | 1.35 ± 0.03 |
| Moisture content (%) | 5.00 | 5.00 | 5.00 | 7.00 | 9.00 | 8.00 |
Physical properties of metronidazole tablets prepared using different diluents_
| Formulations with diluents | ||||||
|---|---|---|---|---|---|---|
| Parameters | I | II | III | IV | V | VI |
| Mean weight (mg) | 503.10 ± 26.62 | 507.00 ± 11.41 | 501.80 ± 13.40 | 511.90 ± 15.21 | 509.20 ± 12.84 | 506.00 ± 9.36 |
| Thickness (mm) | 4.02 ± 0.13 | 4.33 ± 0.06 | 4.38 ± 0.02 | 4.02 ± 0.05 | 4.27 ± 0.06 | 4.08 ± 0.02 |
| Tensile strength (MPa) | 0.78 ± 0.12 | 0.67 ± 0.30 | 0.57 ± 0.05 | 1.19 ± 0.11 | 0.77 ± 0.04 | 1.20 ± 0.23 |
| Friability (%) | 1.20 | 1.95 | 2.00 | 0.78 | 1.1 | 0.69 |
| Disintegration time (min) | 14.01 ± 1.57 | 10.99 ± 1.39 | 10.96 ± 1.08 | 25.40 ± 0.34 | 5.77 ± 2.37 | 0.32 ± 0.06 |
| T80% (min) | 18.00 | 15.00 | 14.00 | 30.00 | 4.00 | 35.00 |
Formula for preparing metronidazole granules and tablets (n = 100 tablets)_
| Formulations | ||||||
|---|---|---|---|---|---|---|
| Ingredients | I | II | III | IV | V | VI |
| Metronidazole (40%) | 20.00 | 20.00 | 20.00 | 20.00 | 20.00 | 20.00 |
| Diluent (39%) | 19.50 | 19.50 | 19.50 | 19.50 | 19.50 | 19.50 |
| Maize starch (10%) | 5.00 | 5.00 | 5.00 | 5.00 | 5.00 | 5.00 |
| Acacia (10%) | 5.00 | 5.00 | 5.00 | 5.00 | 5.00 | 5.00 |
| CSD (0.5%) | 0.25 | 0.25 | 0.25 | 0.25 | 0.25 | 0.25 |
| SSF (0.5%) | 0.25 | 0.25 | 0.25 | 0.25 | 0.25 | 0.25 |
| Total (g) | 50.00 | 50.00 | 50.00 | 50.00 | 50.00 | 50.00 |