Figure 1
Figure 2
Figure 3
Adhesion strength of cp934 gel with and without alginate microparticles (n=6)
| Formulation | Adhesion strength (mean ± SD) g/cm2 |
|---|---|
| cp934 gel without alginate particles | 1.88 ± 0.04 |
| cp934 gel containing alginate particles | 1.94 ± 0.15 |
Effect of different parameters on size of microparticles
| Experiment | Alginate (w/v%) | Cacl2 (w/v%) | Alginate to cacl2 ratio | drug to polymer ratio | Particle size (μm) |
|---|---|---|---|---|---|
| 1 | 1 | 1 | 1:10 | 1:1 | <250 |
| 2 | 0.5 | 1 | 1:10 | 1:1 | 710 |
| 3 | 1 | 2 | 1:10 | 1:1 | 296 |
| 4 | 1 | 1 | 1:5 | 1:1 | 450 |
| 5 | 1 | 1 | 1:10 | 1:5 | 710 |
Run parameters for two – level four factorial experimental design
| Experiments | Alginate solution conc.(w/v%) | CaCl2 solution conc. (w/v%) | Alginate:CaCl2 ratio | Drug:polymer ratio |
|---|---|---|---|---|
| 1 | 1 | 1 | 1:5 | 1:1 |
| 2 | 1 | 1 | 1:10 | 1:1 |
| 3 | 1 | 2 | 1:5 | 1:1 |
| 4 | 1 | 2 | 1:10 | 1:1 |
| 5 | 0.5 | 1 | 1:10 | 1:1 |
| 6 | 0.5 | 1 | 1:5 | 1:1 |
| 7 | 1 | 1 | 1:5 | 1:5 |
| 8 | 1 | 1 | 1:5 | 1:5 |
| 9 | 1 | 2 | 1:10 | 1:5 |
| 10 | 1 | 2 | 1:5 | 1:5 |
| 11 | 0.5 | 2 | 1:5 | 1:5 |
| 12 | 0.5 | 1 | 1:5 | 1:5 |
| 13 | 0.5 | 1 | 1:10 | 1:5 |
| 14 | 0.5 | 2 | 1:10 | 1:1 |
| 15 | 0.5 | 2 | 1:5 | 1:1 |
| 16 | 0.5 | 2 | 1:10 | 1:5 |