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eNOS Promoter Activation by Red Wine Polyphenols: an Interaction Study Cover

eNOS Promoter Activation by Red Wine Polyphenols: an Interaction Study

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Open Access
|Jun 2013

References

  1. [1] Appeldoorn MM et al. Some phenolic compounds increase the nitric oxide level in endothelial cells in vitro. J Agric Food Chem. 2009;57:7693–7699.
  2. [2] Bao M, Lou Y. Flavonoids from seabuckthorn protect endothelial cells (EA.hy926) from oxidized low-density lipoprotein induced injuries via regulation of Lox-1 and eNOS expression. J Cardiovasc Pharmacol. 2006;48:834–841.
  3. [3] Berenbaum, MC. What is synergy? Pharmacol Rev. 1989; 41:93–141.
  4. [4] Bradford, MM. A rapid and sensitive method for the quantitation of microgram quantities utilizing the principle of protein dye binding. Anal Biochem. 1976;72:248–254.
  5. [5] Chan MM, Mattiacci JA, Hwang HS, Shah A, Fong D. Synergy between ethanol and grape polyphenols, quercetin, and resveratrol, in the inhibition of the inducible nitric oxide synthase pathway. Biochem Pharmacol. 2000;60:1539– 1548.
  6. [6] Chen CC, Ke WH, Ceng LH, Hsieh CW, Wung BS. Calcium- and phosphatidylinositol 3-kinase/Akt-dependent activation of endothelial nitric oxide synthase by apigenin. Life Sci. 2010;87:743–749.
  7. [7] Chou TC. Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol Rev. 2006; 58:621–681.
  8. [8] Edgell CJ, McDonald CC, Graham JB. Permanent cell line expressing human factor VIII-related antigen established by hybridization. Proc Natl Acad Sci USA. 1983;80:3734–3737.
  9. [9] Han D, Yi OS, Shin HK. Solubilization of vitamin C in fish oil and synergistic effect with vitamin E in retarding oxidation. J Am Oil Chem Soc. 1991;68:740–743.
  10. [10] Kurin E, Atanasov AG, Donath O, Heiss EH, Dirsch VM, Nagy M. Synergy study of the inhibitory potential of red wine polyphenols on vascular smooth muscle cell proliferation. Planta Med. 2012;78:772–778.
  11. [11] Leikert JF, Räthel TR, Wohlfart P, Cheynier V, Vollmar AM, Dirsch VM. Red wine polyphenols enhance endothelial nitric oxide synthase expression and subsequent nitric oxide release from endothelial cells. Circulation. 2002;106:1614–1617.
  12. [12] Li H et al. Activation of protein kinase C alpha and/or epsilon enhances transcription of the human endothelial nitric oxide synthase gene. Mol Pharmacol. 1998;53:630–637.
  13. [13] Ma XH et al. Synergistic therapeutic actions of herbal ingredients and their mechanisms from molecular interaction and network perspectives. Drug Discov Today. 2009;14:579–588.
  14. [14] Palozza P, Krinsky NI. Beta-carotene and alpha-tocopherol are synergistic antioxidants. Arch Biochem Biophys. 1992;297:184–187.
  15. [15] Peyrat-Maillard MN, Bonnely S, Rondini L, Berset C. Effect of vitamin E and vitamin C on the antioxidant activity of malt rootlets extracts. Lebensm.-Wiss.Technol. 2001;34:176–182.
  16. [16] Räthel TR, Samtleben R, Vollmar AM, Dirsch VM. Activation of endothelial nitric oxide synthase by red wine polyphenols: impact of grape cultivars, growing area and the vinification process. J Hypertens. 2007;25:541–549.
  17. [17] Scarpa M, Rigo A, Maiorino M, Ursini F, Gregolin C. Formation of alpha-tocopherol radical and recycling of alpha-tocopherol by ascorbate during peroxidation of phosphatidylcholine liposomes: An electron paramagnetic resonance study. Biochim Biophys Acta. 1984;801:215–219.
  18. [18] Schmitt CA, Dirsch VM. Modulation of endothelial nitric oxide by plant-derived products. Nitric Oxide. 2009;21:77–91.
  19. [19] St Leger AS, Cochrane AL, Moore F. Factors associated with cardiac mortality in developed countries with particular reference to the consumption of wine. Lancet 1979;313:1017– 1020.
  20. [20] Wallerath T et al. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation. 2002;106:1652– 1658.
  21. [21] Wallerath T, Poleo D, Li H, Förstermann U. Red wine increases the expression of humanendothelial nitric oxide synthase a mechanism that maycontribute to its beneficial cardiovascular effects. J Am Coll Cardiol. 2003;41:471–478.
  22. [22] Wallerath T, Li H, Gödtel-Ambrust U, Schwarz PM, Förstermann U. A blend of polyphenolic compounds explains the stimulatory effect. of red wine on human endothelial NO synthase. Nitric Oxide. 2005;12:97–104.
  23. [23] Wang H, Yang YJ, Qian HY, Zhang Q, Xu H, Li JJ. Resveratrol in cardiovascular disease: what is known from current research? Heart Fail Rev. 2012;17:437–448.
  24. [24] Xu JW, Ikeda K, Yamori Y. Cyanidin-3-glucoside regulates phosphorylation of endothelial nitric oxide synthase. FEBS Letters. 2004;574:176–180.
  25. [25] Zhou B, Jia ZS, Chen ZH, Yang L, Wu LM., Liu ZL. Synergistic antioxidant effect of green tea polyphenols with alpha-tocopherol on free radical initiated peroxidation of linoleic acid in micelles. J Chem Soc Perkin Trans. 2000;2:785–791.
  26. [26] Zhou B, Wu LM, Yang L, Liu ZL. Evidence for alfa-tocopherol regeneration reaction of green tea polyphenols in SDS micelles. Free Radic Biol Med. 2005;38:78–84.
  27. [27] Zimmermann GR, Lehár J, Keith CT. Multi-target therapeutics: when the whole is greater than the sum of the parts. Drug Discov Today 2007;12:34–42.
DOI: https://doi.org/10.2478/afpuc-2013-0013 | Journal eISSN: 2453-6725 (formerly 1338-6786) | Journal ISSN: 0301-2298
Language: English
Page range: 27 - 33
Published on: Jun 27, 2013
Published by: Comenius University in Bratislava, Faculty of Pharmacy
In partnership with: Paradigm Publishing Services
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© 2013 E. Kurin, N. Fakhrudin, M. Nagy, published by Comenius University in Bratislava, Faculty of Pharmacy
This work is licensed under the Creative Commons License.