Ligasure vs. Suture Ligation for Feline Ovariohysterectomy: Faster Ovarian Pedicle Dissection, Lower Early Pain, and Attenuated Fibrinolytic Activation
References
- Davidson EB, Payton ME: Comparison of laparoscopic ovariohysterectomy and ovariohysterectomy in dogs. Vet Surg 2004, 33:62–69.
- Van Goethem B, Schaefers-Okkens A, Kirpensteijn J: Making a rational choice between ovariectomy and ovariohysterectomy in the dog: a discussion of the benefits of either technique. Vet Surg 2006, 35:136–143.
- Olson PN, Johnston SD: New development in small animal population control. J Am Vet Med Assoc 1993, 202:904–909.
- DeTora M, McCarthy RJ: Ovariohysterectomy versus ovariectomy for elective sterilization of female dogs and cats: is removal of the uterus necessary? J Am Vet Med Assoc 2011, 239:1409–1412.
- Overley B, Shofer FS, Goldschmidt MH, Sherer D, Sorenmo KU: Association between ovariohysterectomy and feline mammary carcinoma. J Vet Intern Med 2005, 19:560–563.
- Lemke KA, Runyon CL, Horney BS: Effects of preoperative administration of ketoprofen on anesthetic requirements and signs of postoperative pain in dogs undergoing elective ovariohysterectomy. J Am Vet Med Assoc 2002, 221:1268–1275.
- Griffin B, Bushby PA, McCobb E, White SC, Rigdon-Brestle KY, Appel LD, Makolinski KV, Wilford CL, Bohling MW, Eddlestone SM, Farrell KA, Ferguson N, Harrison K, Howe LM, Isaza NM, Levy JK, Looney A, Moyer MR, Robertson SA, Tyson K: The Association of Shelter Veterinarians’ 2016 veterinary medical care guidelines for spay-neuter programs. J Am Vet Med Assoc 2016, 249:165–188.
- Gower S, Mayhew P: Canine laparoscopic and laparoscopic-assisted ovariohysterectomy and ovariectomy. Compend Contin Educ Vet 2008, 30:430–440.
- Peycke LE: Facilitation of soft tissue surgery: surgical staplers and vessel sealing devices. Vet Clin North Am Small Anim Pract 2015, 45:451–461.
- Adin CA: Complications of ovariohysterectomy and orchiectomy in companion animals. Vet Clin North Am Small Anim Pract 2011, 41:1023–1039.
- Schwarzkopf I, Van Goethem B, Vandekerckhove PM, De Rooster H: Vessel sealing versus suture ligation for canine ovarian pedicle haemostasis: a randomised clinical trial. Vet Rec 2015, 176:125.
- Dumartinet C, Matres-Lorenzo L, Linsart A, Bérard A, Bernard F: Comparison of conventional ligatures and a vessel sealing device for haemostasis during open ovariohysterectomy in rabbits. N Z Vet J 2022, 70:256–262.
- Landman J, Kerbl K, Rehman J, Andreoni C, Humphrey WC, Collyer W, Olweny E, Sundaram C, Clayman RV: Evaluation of a vessel sealing system, bipolar electrosurgery, harmonic scalpel, titanium clips, endoscopic gastrointestinal anastomosis vascular staples and sutures for arterial and venous ligation in a porcine model. J Urol 2003, 169:697–700.
- Mayhew PD, Culp WT, Pascoe PJ, Arzi NV: Use of the Ligasure vessel-sealing device for thoracoscopic peripheral lung biopsy in healthy dogs. Vet Surg 2012, 41:523–528.
- Risselada M, Ellison GW, Bacon NJ, Polyak MM, van Gilder J, Kirkby K, Kim SE: Comparison of 5 surgical techniques for partial liver lobectomy in the dog for intraoperative blood loss and surgical time. Vet Surg 2010, 39:856–862.
- Wouters EG, Buishand FO, Kik M, Kirpensteijn J: Use of a bipolar vessel-sealing device in resection of canine insulinoma. J Small Anim Pract 2011, 52:139–145.
- Pearson H: The complications of ovariohysterectomy in the bitch. J Small Anim Pract 1973, 14:257–266.
- Mayhew PD, Brown DC: Comparison of three techniques for ovarian pedicle hemostasis during laparoscopic-assisted ovariohysterectomy. Vet Surg 2007, 36:541–547.
- De Oliveira Carapeba G, Nacacio IP, Stelle ABF, Bruno TS, Nacacio GM, Costa Júnior JS, Giuffrida R, Teixeira Neto FJ, Cassu RN: Comparison of perioperative analgesia using the infiltration of the surgical site with ropivacaine alone and in combination with meloxicam in cats undergoing ovariohysterectomy. BMC Vet Res 2020, 16:1–10.
- Brondani JT, Luna SP, Padovani CR: Refinement and initial validation of a multidimensional composite scale for use in assessing acute postoperative pain in cats. Am J Vet Res 2011, 72(2):174-183.
- Monarski CJ, Jaffe MH, Kass PH: Decreased surgical time with a vessel sealing device versus a surgical stapler in performance of canine splenectomy. J Am Anim Hosp Assoc 2014, 50:42–45.
- McLean EJ, Woodward AP, Ryan SD: Comparison of the use of a vessel-sealing device versus ligatures for occlusion of uterine tissues during ovariohysterectomy or ovariectomy in rabbits (Oryctolagus cuniculus). Am J Vet Res 2020, 81:755–759.
- Shaukat A, Anjum MA: Comparison of axillary lymph node dissection by using Ligasure vessel sealing system vs conventional thread ligation in patients undergoing modified radical mastectomy for carcinoma of breast. Ann Punjab Med Coll 2020, 14:254–258.
- Peterson SL, Stranahan PL, Schmaltz D, Mihaichuk C, Cosgriff N: Comparison of healing process following ligation with sutures and bipolar vessel sealing. Surg Technol Int 2002, 10:55–60.
- Bubalo V, Moens YP, Holzmann A, Coppens P: Anaesthetic sparing effect of local anaesthesia of the ovarian pedicle during ovariohysterectomy in dogs. Vet Anaesth Analg 2008, 35:537–542.
- Vicente D, Bergström A: Evaluation of intraoperative analgesia provided by incisional lidocaine and bupivacaine in cats undergoing ovariohysterectomy. J Feline Med Surg 2018, 20:922–927.
- Devitt CM, Cox RE, Hailey JJ: Duration, complications, stress, and pain of open ovariohysterectomy versus a simple method of laparoscopic-assisted ovariohysterectomy in dogs. J Am Vet Med Assoc 2005, 227:921–927.
- Tallant A, Ambros B, Freire C, Sakals S: Comparison of intraoperative and post-operative pain during canine ovariohysterectomy and ovariectomy. Can Vet J 2016, 57:741–746.
- Minto BW, Filgueira FGF, de Alcântara BM, Sargi LF, Magalhães Moi TS, Dias LGGG: Comparison of intraoperative nociception and post-operative acute pain after traditional or minimally invasive ovariohysterectomy in dogs. Acta Sci Vet 2021, 49:1822.
- Sunghan J, Manmoo S, Suriyasathaporn W, Warrit K, Kusolphat P: Comparison of the efficacy and perioperative pain between vessel sealing and suture ligation for median laparotomy in dogs. Vet World 2023, 16(2):386-394.
- Case JB, Boscan PL, Monnet EL, Niyom SR, Imhoff DJ, Wallace ML, Smeak DD: Comparison of surgical variables and pain in cats undergoing ovariohysterectomy, laparoscopic-assisted ovariohysterectomy, and laparoscopic ovariectomy. J Am Anim Hosp Assoc 2015, 51:1–7.
- Oliveira JP, Mencalha R, Sousa CA, Abidu-Figueiredo M, Jorge SF: Pain assessment in cats undergoing ovariohysterectomy by midline or lateral celiotomy through use of a previously validated multidimensional composite pain scale. Acta Cir Bras 2014, 29:633–638.
- Banchi P, Quaranta G, Ricci A, Mauthe von Degerfeld M: Reliability and construct validity of a composite pain scale for rabbit (CANCRS) in a clinical environment. PLoS ONE 2020, 15:e0221377.
- Tacconelli E, Mueller NF, Lemmen S, Mutters NT, Hagel S, Meyer E: Infection risk in sterile operative procedures: a systematic review and meta-analysis. Dtsch Arztebl Int 2016, 113:271–278.
- Kwok SY, Chung CC, Tsui KK, Li MKW: A double-blind, randomized trial comparing Ligasure and Harmonic Scalpel hemorrhoidectomy. Dis Colon Rectum 2005, 48:344–348.
- Ntourakis D, Sergentanis TN, Georgiopoulos I, Papadopoulou E, Liasis L, Kritikos E, Tzardis P, Laopodis V: Subclinical activation of coagulation and fibrinolysis in laparoscopic cholecystectomy: do risk factors exist? Int J Surg 2011, 9:374–377.
- Luo Y, Li X, Dong J, Sun W: A comparison of surgical outcomes and complications between hemostatic devices for thyroid surgery: a network meta-analysis. Eur Arch Otorhinolaryngol 2017, 274:1269–1278.
- Garas G, Okabayashi K, Ashrafian H, Shetty K, Palazzo F, Tolley N, Darzi A, Athanasiou T, Zacharakis E: Which hemostatic device in thyroid surgery? A network meta-analysis of surgical technologies. Thyroid 2013, 23:1138–1150.
- Muraro L, White RS: Complications of ovariohysterectomy procedures performed in 1880 dogs. Tierarztl Prax Ausg K Kleintiere Heimtiere 2014, 42:297–302.
- Yons SD, Law KSK: Laparoscopic vessel sealing technologies. J Minim Invasive Gynecol 2013, 20:301–307.
- Muir P, Goldsmid SE, Bellenger CR: Megacolon in a cat following ovariohysterectomy. Vet Rec 1991, 129:512–513.
- Boza S, Lucas X, Zarelli M, Soler M, Belda E, Agut A: Late abscess formation caused by silk suture following hysterectomy in a female dog. Reprod Domest Anim 2009, 44:920–923.
- Bhattarai B, Kuricová M, Lipták T, Murachova O, Chersakova O, Kozlov N, Pozyabin S: Ventral slot surgery for management of ganglioneuroma and IVDD in a cat. Acta Vet- Beograd 2024, 74(3): 484-490.
Language: English
Page range: 212 - 227
Submitted on: Sep 25, 2025
Accepted on: May 11, 2026
Published on: Jun 23, 2026
Published by: University of Belgrade, Faculty of Veterinary Medicine
In partnership with: Paradigm Publishing Services
Keywords:
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© 2026 Damla Tuğçe Okur, Şifanur Aydin, Alper Yasin Çiplak, Selçuk Özdemir, Şeyma Aydin, Elif Dalkilinç, Vefa Tohumcu, Sitkican Okur, Şükrü Değirmençay, Ayşe Gölgeli Bedir, Büşra Baykal, Şaab Elban, published by University of Belgrade, Faculty of Veterinary Medicine
This work is licensed under the Creative Commons Attribution 4.0 License.