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Collagen-I, Collagen-IV and Aquaporin-IV Protein Expressions Are Up-Regulated in Sheep Naturally Infected with Coenurosis; A Histopathological and Immunohistochemical Study

Acta Veterinaria
Volume 75 (2025): Issue 3 (September 2025)
By:
Open Access
|Sep 2025

References

  1. Akkuş E, Oğuz FE: Molecular prevalence of Coenurus cerebralis in sheep with neurological symptoms in Iğdır Province Türkiye. Pak Vet J 2024, 44(2):499-503.
    Search in Google ScholarBack to article
  2. Avcioglu H, Yildirim A, Duzlu O, Inci A, Terim KK, Balkaya I: Prevalence and molecular characterization of bovine coenurosis from Eastern Anatolian region of Turkey. Vet Parasitol 2011, 176(1):59-64.
    Search in Google ScholarBack to article
  3. Constable PD, Hinchcliff KW, Done SH, Grünberg W: Veterinary medicine: a textbook of the diseases of cattle, horses, sheep, pigs and goats: Elsevier Health Sciences; 2016.
    Search in Google ScholarBack to article
  4. Mohammed NH. Prevalence, morphological and biochemical study of larval stage Coenurus cerebralis of Taenia multiceps in sheep. Iraqi J Vet Sci 2020, 34(1):159-163.
    Search in Google ScholarBack to article
  5. Varcasia A, Tamponi C, Ahmed F, Cappai MG, Porcu F, Mehmood N, Dessi G, Scala A: Taenia multiceps coenurosis: a review. Parasites & Vectors 2022, 15(1):84.
    Search in Google ScholarBack to article
  6. Ajaj EA, Mohammad HA, Gharban HA: First molecular confirmation of Coenurus cerebralis in sheep and goats with neurological behaviors in Iraq. Vet World 2021, 14(6):1420.
    Search in Google ScholarBack to article
  7. Amer S, ElKhatam A, Fukuda Y, Bakr LI, Zidan S, Elsify A, Mohammed MA, Tada C, Nakai Y: Clinical, pathological, and molecular data concerning Coenurus cerebralis in sheep in Egypt. Data Br 2018,16:1-9.
    Search in Google ScholarBack to article
  8. Comba B, Mert H, Comba A, Mis L, Mert N: The some hematological and biochemical parameters in Karakul and Norduz sheep. Van Vet J 2017, 28(3):137-140.
    Search in Google ScholarBack to article
  9. Farjani Kish G, Khodakaram-Tafti A, Hajimohammadi A, Ahmadi N: Clinical and morphopathological characteristics of an enzootic occurrence of acute coenurosis (Coenurus cerebralis) in a sheep herd. J Parasit Dis 2015, 39:280-283.
    Search in Google ScholarBack to article
  10. Akbari M, Moazeni M, Oryan A, Sharifiyazdi H, Amrabadi O: Experimental cerebral and non-cerebral coenurosis in goats: A comparative study on the morphological and molecular characteristics of the parasite. Vet Parasitol 2015, 211(3-4):201-207.
    Search in Google ScholarBack to article
  11. Alvi MA, Ohiolei JA, Saqib M, Tayyab MH, Zafar Khan MU, Li L, Aqib AI, Hassan A, Alvi AA, Qamar W, Fu BQ, Yan HB, Jia WZ: First report on molecular characterization of Taenia multiceps isolates from sheep and goats in Faisalabad, Pakistan. Front Vet Sci 2020, 7:594599.
    Search in Google ScholarBack to article
  12. Giadinis N, Psychas V, Polizopoulou Z, Papadopoulos E, Papaioannou N, Komnenou A, Thomas AL, Petridou EJ, Konstantinou MK, LafiSQ, Brellou GD: Acute coenurosis of dairy sheep from 11 flocks in Greece. New Zealand Vet J 2012, 60(4):247-253.
    Search in Google ScholarBack to article
  13. Dincel GC, Yavuz O, Yildirim S, Al-Olayan EM, El-Ashram S: ADAMTS-13 and HMGB1-induced oxidative stress in Taenia multiceps-infected animals. Sci Rep 2023, 13(1):17929.
    Search in Google ScholarBack to article
  14. Rahsan Y, Nihat Y, Bestami Y, Adnan A, Nuran A: Histopathological, immunohistochemical, and parasitological studies on pathogenesis of in sheep. J Vet Res 2018, 62(1):35-41.
    Search in Google ScholarBack to article
  15. Yılmaz R, Özyıldız Z, Yumuşak N: Pathomorphological findings of Coenurus cerebralis in sheep. Harran Üniv Vet Fak Derg 2014, 3(2):73-77.
    Search in Google ScholarBack to article
  16. Tavassoli M, Malekifard F, Soleimanzadeh A, Tajik H: Prevalence of Coenurus cerebralis in sheep in Northwest of Iran. Vet Res For 2011, 2(4):274-276.
    Search in Google ScholarBack to article
  17. Alahmari A: Blood-brain barrier overview: structural and functional correlation. Neural Plast 2021, 2021(1):6564585.
    Search in Google ScholarBack to article
  18. Halder SK, Sapkota A, Milner R: The importance of laminin at the blood-brain barrier. Neural Reg Res 2023, 18(12):2557-2563.
    Search in Google ScholarBack to article
  19. Pintér P, Alpár A: The role of extracellular matrix in human neurodegenerative diseases. Int J Mol Sci 2022, 23(19):11085.
    Search in Google ScholarBack to article
  20. Naomi R, Ridzuan PM, Bahari H: Current insights into collagen type I. Polymers 2021, 13(16):2642.
    Search in Google ScholarBack to article
  21. Wareham LK, Baratta RO, Del Buono BJ, Schlumpf E, Calkins DJ. Collagen in the central nervous system: contributions to neurodegeneration and promise as a therapeutic target. Mol Neurodeg 2024, 19(1):11.
    Search in Google ScholarBack to article
  22. D’Ambrosi N, Apolloni S: Fibrotic scar in neurodegenerative diseases. Front Immunol 2020, 11:1394.
    Search in Google ScholarBack to article
  23. Fernández-Klett F, Priller J: The fibrotic scar in neurological disorders. Brain Pathol 2014, 24(4):404-413.
    Search in Google ScholarBack to article
  24. Hara M, Kobayakawa K, Ohkawa Y, Kumamaru H, Yokota K, Saito T, Kijima K, Yoshizaki S, Harimaya K, Nakashima Y, Okada S: Interaction of reactive astrocytes with type I collagen induces astrocytic scar formation through the integrin–N-cadherin pathway after spinal cord injury. Nat Med 2017, 23(7):818-828.
    Search in Google ScholarBack to article
  25. Cescon M, Chen P, Castagnaro S, Gregorio I, Bonaldo P: Lack of collagen VI promotes neurodegeneration by impairing autophagy and inducing apoptosis during aging. Aging (Albany NY) 2016, 8(5):1083.
    Search in Google ScholarBack to article
  26. Mader S, Brimberg L: Aquaporin-4 water channel in the brain and its implication for health and disease. Cells 2019, 8(2):90.
    Search in Google ScholarBack to article
  27. Vandebroek A, Yasui M: Regulation of AQP4 in the central nervous system. Int J Mol Sci 2020, 21(5):1603.
    Search in Google ScholarBack to article
  28. Iacovetta C, Rudloff E, Kirby R: The role of aquaporin 4 in the brain. Vet Clin Pathol 2012, 41(1):32-44.
    Search in Google ScholarBack to article
  29. Tang G, Yang G-Y: Aquaporin-4: A potential therapeutic target for cerebral edema. Int J Mol Sci 2016, 17(10):1413.
    Search in Google ScholarBack to article
  30. Akcakavak G, Kazak F, Karatas O, Alakus H, Alakus I, Kirgiz O, Celik Z, Deveci MZY, Ozdemir O, Tuzcu M: Eucalyptol regulates Nrf2 and NF-kB signaling and alleviates gentamicin-induced kidney injury in rats by downregulating oxidative stress, oxidative DNA damage, inflammation, and apoptosis. Toxicol Mech Method 2024, 34(4):413-422.
    Search in Google ScholarBack to article
  31. Kazak F, Akcakavak G, Alakus I, Alakus H, Kirgiz O, Karatas O, Deveci MZY, Coskun P: Proanthocyanidin alleviates testicular torsion/detorsion-induced ischemia/reperfusion injury in rats. Tissue and Cell 2024, 89:102459.
    Search in Google ScholarBack to article
  32. Rehman TU, Elsaid FG, Toledo MMG, Gentile A, Gul RA, Rashid M, Aleem MT, Zaman MA: Fasciolosis: Recent update in vaccines development and their efficacy. Pak Vet J 2023, 43(2): 224-231.
    Search in Google ScholarBack to article
  33. Ceylan C, Ekici ÖD: Molecular investigation of ovine and caprine anaplasmosis in south-Eastern Anatolia region of Turkey. Pak Vet J 2023, 43(1):139-145.
    Search in Google ScholarBack to article
  34. Ur Rehman T, Elsaid FG, Toledo MMG, Gentile A, Gul RA, Rashid M, Aleem MT, Zaman MA: Fasciolosis: recent update in vaccines development and their efficacy. Pak Vet J 2023, 43:224-231.
    Search in Google ScholarBack to article
  35. Gicik Y, Kara M, Arslan MO: Prevalence of Coenurus cerebralis in sheep in Kars Province, Turkey. Bull Vet Inst Pulawy 2007, 51(3):379.
    Search in Google ScholarBack to article
  36. Sonmez B, Koroglu E, Simsek S: Molecular characterization and detection of variants of Taenia multiceps in sheep in Turkey. Parasitology 2017, 144(2):220-225.
    Search in Google ScholarBack to article
  37. Güçlü F, Uslu U, Ozdemir O: Bilateral bone perforation caused by Coenurus cerebralis in a sheep: case report. Turkiye Parazitolojii Dergisi 2006, 30(4):282-284.
    Search in Google ScholarBack to article
  38. Uztimür M, Dörtbudak MB: Evaluation of brain injury in goats naturally infected with Coenurus cerebralis; brain specific biomarkers, acute inflammation, and DNA oxidation. Res Vet Sci 2023, 165:105043.
    Search in Google ScholarBack to article
  39. Smolders SM-T, Kessels S, Vangansewinkel T, Rigo J-M, Legendre P, Brône B: Microglia: Brain cells on the move. Prog Neurobiol 2019, 178:101612.
    Search in Google ScholarBack to article
  40. Wu D, Chen Q, Chen X, Han F, Chen Z, Wang Y: The blood–brain barrier: structure, regulation, and drug delivery. Signal Transduct Target Ther 2023, 8(1):217.
    Search in Google ScholarBack to article
  41. Zador Z, Stiver S, Wang V, Manley GT: Role of aquaporin-4 in cerebral edema and stroke. Aquaporins 2009, 159-170.
    Search in Google ScholarBack to article
  42. Zeng XN, Xie LL, Liang R, Sun XL, Fan Y, Hu G: AQP4 knockout aggravates ischemia/reperfusion injury in mice. CNS Neurosci Ther 2012, 18(5):388-394.
    Search in Google ScholarBack to article
  43. Promeneur D, Lunde LK, Amiry-Moghaddam M, Agre P: Protective role of brain water channel AQP4 in murine cerebral malaria. Proc Natl Acad Sci 2013, 110(3):1035-1040.
    Search in Google ScholarBack to article
  44. Manley GT, Fujimura M, Ma T, Noshita N, Filiz F, Bollen AW, Chan P, Verkman AS: Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Nat Med 2000, 6(2):159-163.
    Search in Google ScholarBack to article
  45. Promeneur D, Liu Y, Maciel J, Agre P, King LS, Kumar N: Aquaglyceroporin PbAQP during intraerythrocytic development of the malaria parasite Plasmodium berghei. Proc Natl Acad Sci 2007, 104(7):2211-2216.
    Search in Google ScholarBack to article
  46. Papadopoulos MC, Manley GT, Krishna S, Verkman A: Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema. FASEB J 2004, 18(11):1291-1293.
    Search in Google ScholarBack to article
  47. Tait MJ, Saadoun S, Bell BA, Verkman AS, Papadopoulos MC: Increased brain edema in aqp4-null mice in an experimental model of subarachnoid hemorrhage. Neuroscience 2010, 167(1):60-67.
    Search in Google ScholarBack to article
  48. Fadiel A, Isokpehi RD, Stambouli N, Hamza A, Benammar-Elgaaied A, Scalise TJ: Protozoan parasite aquaporins. Expert Rev Proteomics 2009, 6(2):199-211.
    Search in Google ScholarBack to article
  49. Bruschi F, Pinto B: Matrix metalloproteinases in parasitic infections. Pathophysiological aspects of proteases, 2017, pp 321-352.
    Search in Google ScholarBack to article
DOI: https://doi.org/10.2478/acve-2025-0023 | Journal eISSN: 1820-7448 | Journal ISSN: 0567-8315
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Language: English
Page range: 295 - 308
Submitted on: Mar 1, 2025
Accepted on: Jun 30, 2025
Published on: Sep 18, 2025
Published by: University of Belgrade, Faculty of Veterinary Medicine
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
Coenurosis,
sheep,
collagen-I,
collagen-IV,
aquaporin-IV
Related subjects:
Medicine,
Veterinary medicine

© 2025 Ozhan Karatas, Gokhan Akcakavak, published by University of Belgrade, Faculty of Veterinary Medicine
This work is licensed under the Creative Commons Attribution 4.0 License.

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