Comparison of the Effects of Autologous Cytokine-Rich Serum (ACRS) and Platelet-Rich Plasma (PRP) on Skin Wound Healing

Hanifi Erol; Erol Karakas; Mustafa Ermis; Gokhan Akcakavak; Nevzat Emre Aslan; Ozhan Karatas

doi:10.2478/acve-2025-0013

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Comparison of the Effects of Autologous Cytokine-Rich Serum (ACRS) and Platelet-Rich Plasma (PRP) on Skin Wound Healing

Acta Veterinaria

Volume 75 (2025): Issue 2 (June 2025)

By: Hanifi Erol , Erol Karakas , Mustafa Ermis , Gokhan Akcakavak , Nevzat Emre Aslan and Ozhan Karatas

Open Access

|Jun 2025

Abstract

Wound healing is one of the most complex biological events, involving physiological processes such as tissue restoration and intricate cellular and molecular activities. The aim of this study was to investigate the effects of Autologous Cytokine Rich Serum (ACRS) and Platelet-rich plasma (PRP) on wound healing and to compare their impact on tissue repair using histopathological and immunohistochemical methods. A total of 42 healthy Wistar-Albino rats were used as material. The histopathological and immunohistochemical evaluations showed that ACRS is more effective than PRP on wound healing. The superior efficacy of ACRS is attributed to its stimulation of anti-inflammatory cytokines and provision of essential nutrients such as amino acids, vitamins, and lipids. Further detailed studies are recommended to explore these findings.

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Articles in this issue

DOI: https://doi.org/10.2478/acve-2025-0013 | Journal eISSN: 1820-7448 | Journal ISSN: 0567-8315

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Language: English

Page range: 151 - 165

Submitted on: Jan 8, 2025

Accepted on: Feb 27, 2025

Published on: Jun 16, 2025

Published by: University of Belgrade, Faculty of Veterinary Medicine

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

rat,

wound,

PRP,

ACRS

Related subjects:

Medicine,

Veterinary medicine

© 2025 Hanifi Erol, Erol Karakas, Mustafa Ermis, Gokhan Akcakavak, Nevzat Emre Aslan, Ozhan Karatas, published by University of Belgrade, Faculty of Veterinary Medicine
This work is licensed under the Creative Commons Attribution 4.0 License.

Volume 75 (2025): Issue 2 (June 2025)