Have a personal or library account? Click to login
Comparison of the Serum Protein Electrophoretic Pattern and Concentrations of Acute Phase Proteins in Bitches with and Without Mammary Gland Tumors Cover

Comparison of the Serum Protein Electrophoretic Pattern and Concentrations of Acute Phase Proteins in Bitches with and Without Mammary Gland Tumors

Acta Veterinaria
Volume 73 (2023): Issue 4 (December 2023)
By: Csilla Tóthová,  Alexandra Valenčáková,  Ľubica Horňáková and  Oskar Nagy  
Open Access
|Dec 2023

References

  1. 1. Sorenmo K: Canine mammary gland tumors. Vet Clin Am Small Anim Pract 2003, 33:573-596.
    Search in Google Scholar
  2. 2. Benavente MA, Bianchi CP, Aba MA: Canine mammary tumors: risk factors, prognosis and treatments. J Vet Adv 2016, 6:1291-1300.
    Search in Google Scholar
  3. 3. Benjamin SA, Lee AC, Saunders WJ: Classification and behavior of canine mammary epithelial neoplasms based on life-span observations in Beagles. Vet Pathol 1999, 36:423-436.
    Search in Google Scholar
  4. 4. Peña L, Perez-Alenza M, Rodriguez B, Nieto A: Canine inflammatory mammary carcinoma: histopathology, immunohistochemistry and clinical implications of 21 cases. Breast Cancer Res Treat 2003, 78:141-148.
    Search in Google Scholar
  5. 5. Kurilj A, Marko H, Branka A, Kresimir S, Ivan C, Sostaric Z: Histopathological evaluation and immunohistochemical study of estrogen receptor α, HER-2 and Ki-67 in canine neoplastic mammary lesions. Vet Arhiv 2011, 81:709-722.
    Search in Google Scholar
  6. 6. Reddy GBM, Kumar P, Kumar R, Pawaiya RVS, Ravindran R: Histopathological classification and incidence of canine mammary tumors. Indian J Vet Pathol 2009, 33:152-155.
    Search in Google Scholar
  7. 7. Zamani-Ahmadmahmudi M, Nassiri SM, Rahbarghazi R: Serological proteome analysis of dogs with breast cancer unveils common serum biomarkers with human counterparts. Electrophor 2014, 35:901-910.
    Search in Google Scholar
  8. 8. Valdivia G, Alonso-Diez Á, Pérez-Alenza D, Peña L: From conventional to precision therapy in canine mammary cancer: A comprehensive review. Front Vet Sci 2021, 8:623800.
    Search in Google Scholar
  9. 9. Seker D, Kaya O, Adabag A, Necipoglu G, Baran I: Role of preoperative plasma CA 15-3 and carcinoembryonic antigen levels in determining histopathologic conventional prognostic factors for breast cancer. World J Surg 2003, 27:519-521.
    Search in Google Scholar
  10. 10. Duffy J, Duggan C, Keane R, Hill ADK, McDermott E, Crown J, O’Higgins N: High preoperative CA 15-3 concentrations predict adverse outcome in node-negative and node-positive breast cancer: study of 600 patients with histologically confirmed breast cancer. Clin Chem 2004, 50:559-563.
    Search in Google Scholar
  11. 11. Al-Azawi D, Kelly G, Myers E, McDermott EW, Hill AD, Duffy MJ, Higgins NO: CA 15-3 is predictive of response and disease recurrence following treatment in locally advanced breast cancer. BMC Cancer 2006, 6:220.
    Search in Google Scholar
  12. 12. Emi Tokuda MD, Yoshiya Horimoto MD, Atsushi Arakawa MD, Himuro T, Senuma K, Nakai K, Saito M: Differences in Ki67expressions between pre-and post-neoadjuvant chemotherapy specimens might predict early recurrence of breast cancer. Hum Pathol 2017, 63:40-45.
    Search in Google Scholar
  13. 13. Mortensen RF, Rudczynski AB: Prognostic significance of serum CRP levels and lymphoid cell infiltrates in human breast cancer. Oncology 1982, 39:129-133.
    Search in Google Scholar
  14. 14. O’Hanlon DM, Lynch J, Cormican M, Given HF: The acute-phase response in breast carcinoma. Anticancer Res 2002, 22:1289-1293.
    Search in Google Scholar
  15. 15. Tecles F, Caldin M, Zanella A, Membiela F, Tvarijonaviciute A, Martínez Subiela S, Cerón JJ: Serum acute phase protein concentrations in female dogs with mammary tumors. J Vet Diagn Invest 2009, 21:214-219.
    Search in Google Scholar
  16. 16. Franco-Martínez L, Gelemanović A, Horvatić A, Contreras-Aguilar MD, Dbrowski R, Mrljak V, Cerón JJ, Martínez-Subiela S, Tvarijonaviciute A: Changes in serum and salivary proteins in canine mammary tumors. Animals 2020, 10:741.
    Search in Google Scholar
  17. 17. Jania B, Andraszek K: Application of native agarose gel electrophoresis of serum proteins in veterinary diagnostics. J Vet Res 2016, 60:501-508.
    Search in Google Scholar
  18. 18. Gama FG, Santana AE, Filho EC, Nogueira CA: Agarose gel electrophoresis of cerebrospinal fluid proteins in dogs after sample concentration using a membrane microconcentrator technique. Vet Clin Pathol 2007, 36:85-88.
    Search in Google Scholar
  19. 19. Vavricka SR, Burri E, Beglinger C, Degen L, Manz M: Serum protein electrophoresis: An underused but very useful test. Digestion 2009, 79:203-210.
    Search in Google Scholar
  20. 20. Gerou-Ferriani M, McBrearty AR, Burchmore RJ, Jayawardena KGI, Eckersall PD, Morris JS: Agarose gel serum protein electrophoresis in cats with and without lymphoma and preliminary results of tandem mass fingerprinting analysis. Vet Clin Pathol 2011, 40:159-173.
    Search in Google Scholar
  21. 21. Owen LN: Classification of tumors in domestic animals. World Health Organization, Geneva, 1980.
    Search in Google Scholar
  22. 22. Gilson SD, Stone E: Principles of oncologic surgery. Contin Educ Small Anim 1990, 12:827-835.
    Search in Google Scholar
  23. 23. Misdorp W, Else RW, Hellman I, Lipscomb TP: Histological classification of mammary tumors of the dog and cat. In: World Health Organization International Histological Classification of Tumors of Domestic Animals. Series 2, vol. 7, no. 2, Armed Forces Institute of Pathology, Washington, DC, 1993.
    Search in Google Scholar
  24. 24. Finora K: Common paraneoplastic syndromes. Clin Tech Small Anim Pract 2003, 18:123-126.
    Search in Google Scholar
  25. 25. Cerón JJ, Eckersall PD, Martinez Subiela S: Acute-phase proteins in dogs and cats: current knowledge and future perspectives. Vet Clin Pathol 2005, 34:85-99.
    Search in Google Scholar
  26. 26. Childress MO: Hematologic abnormalities in the small animal cancer patient. Vet Clin North Am Small Anim Pract 2012, 42:123-155.
    Search in Google Scholar
  27. 27. Al-Muhtaseb SI: Serum and saliva protein levels in females with breast cancer. Oncol Lett 2014, 8:2752-2756.
    Search in Google Scholar
  28. 28. Satilmis F, Alan BS, Altunok V, Kivrak MB, Demirsöz M, Alkan H, Aydin I: The effect of size and clinical staging of mammary tumors on blood parameters in bitches. Acta Sci Vet 2022, 50: 886.
    Search in Google Scholar
  29. 29. Oliveira MR, Carneiro RA, Nunes FC, Teixeira SV, Vieira TC, Lavalle GE, Cassali GD: Hematological and biochemical alterations in female dogs with mammary cancer and inflammatory carcinoma. Arq Bras Med Vet Zootec 2022, 74:428-436.
    Search in Google Scholar
  30. 30. Aldred AR, Schreiber G: The negative acute phase protein. In: Mackiewicz I, Kushner I, Baumann H: Acute phase proteins. Molecular biology, biochemistry, and clinical applications. Boca Raton, Florida, CRC Press, 1993, 21-37.
    Search in Google Scholar
  31. 31. Vilhena H, Tvarijonaviciute A, Cerón JJ, Figueira AC, Miranda S, Ribeiro A, Canadas A, Dias-Pereira P, Rubio CP, Franco L, Tecles F, Cabeças R, Pastor J, Silvestre-Ferreira AC: Acute phase proteins and biomarkers of oxidative status in feline spontaneous malignant mammary tumors. Vet Comp Oncol 2019, 17:394-406.
    Search in Google Scholar
  32. 32. Costa-Santos K, Damasceno K, Dias Portela R, Lima Santos F, Carneiro Araújo G, Ferreira Martins-Filho E, Pereira Silva L, Barral TD, Alvarenga Santos S, Estrela-Lima A: Lipid and metabolic profiles in female dogs with mammary carcinoma receiving dietary fish oil supplementation. BMC Vet Res 2019, 15:401.
    Search in Google Scholar
  33. 33. Hochepied T, Berger FG, Baumann H, Libert C: α1-Acid glycoprotein: an acute phase protein with inflammatory and immunomodulating properties. Cytokine Growth Factor Rev 2003, 14:25-34.
    Search in Google Scholar
  34. 34. Ceciliani F, Lecchi C: The immune functions of α1 acid glycoprotein. Curr Protein Pept Sci 2019, 20:505-524.
    Search in Google Scholar
  35. 35. Rikihasa Y, Yamamoto S, Kwak I, Igbal Z, Kociba G, Mott J, Chichana Siriwithaya W: C-reactive protein and α1-acid glycoprotein levels in dogs infected with Ehrlichia canis. J Clin Microbiol 1994, 32:912-917.
    Search in Google Scholar
  36. 36. Hagman R: Serum α-1-acid glycoprotein concentrations in 26 dogs with pyometra. Vet Clin Pathol 2011, 40:52-59.
    Search in Google Scholar
  37. 37. Ogilvie GK, Walters LM, Greeley SG, Henkel SE, Salman MD: Concentration of α1-acid glycoprotein in dogs with malignant neoplasia. J Am Vet Med Assoc 1993, 203:1144-1146.
    Search in Google Scholar
  38. 38. Thougaard AV, Hellmén E, Pedersen HD, Jensen AL: Correlation between α1-acid glycoprotein and total sialic acid in serum from dogs with tumours. J Vet Med A 1999, 46:231-237.
    Search in Google Scholar
  39. 39. Szarková A, Tóthová C, Weissová T, Lukáč B, Turňa H, Kottferová L, Nagy O: Evaluation of acute phase proteins in dogs suffering from various diseases. Int J Vet Sci 2023, 12:82-88.
    Search in Google Scholar
  40. 40. Mischke R, Waterston M, Eckersall PD: Changes in C-reactive protein and haptoglobin in dogs with lymphatic neoplasia. Vet J 2007, 174:188-192.
    Search in Google Scholar
  41. 41. Atherton MJ, Braceland M, Fontaine S, Waterston MM, Burchmore RJ, Eadie S, Eckersall PD, Morris JS: Changes in the serum proteome of canine lymphoma identified by electrophoresis and mass spectrometry. Vet J 2013, 196:320-324.
    Search in Google Scholar
  42. 42. Planellas M, Bassols A, Siracusa C, Saco Y, Giménez M, Pato R, Pastor J: Evaluation of serum haptoglobin and C-reactive protein in dogs with mammary tumors. Vet Clin Pathol 2009, 38:348-352.
    Search in Google Scholar
  43. 43. Chen F, Han B, Meng Y, Han Y, Liu B, Zhang B, Chang Y, Cao P, Fan Y, Tan K: Ceruloplasmin correlates with immune infiltration and serves as a prognostic biomarker in breast cancer. Aging 2021, 13:20438-20467.
    Search in Google Scholar
  44. 44. Senra Valera A, Lopez Saez JJ, Quintela Senra D: Serum ceruloplasmin as a diagnostic marker of cancer. Cancer Lett 1997, 121:139-145.
    Search in Google Scholar
  45. 45. Dickerson BD, Geist BL, Spillman WB Jr, Robertson JL: Canine cancer screening via ultraviolet absorbance and fluorescence spectroscopy of serum proteins. Appl Opt 2007, 46:8080-8088.
    Search in Google Scholar
  46. 46. Nowak M, Madej JP, Rossowska J, Madej JA: Involvement of CD8+ cells in protective mechanisms in canine mammary adenocarcinomas (short communication). Bull Vet Inst Pul 2007, 51:445-448.
    Search in Google Scholar
  47. 47. Tecles F, Spiranelli E, Bonfanti U, Cerón JJ, Paltrinieri S: Preliminary studies of serum acute-phase protein concentrations in hematologic and neoplastic diseases of the dog. J Vet Intern Med 2005, 19:865-870.
    Search in Google Scholar
  48. 48. Nieto A, Peña L, Perez-Alenza MD: Immunohistologic detection of estrogen receptor alpha in canine mammary tumors: Clinical and pathological associations and prognostic significance. Vet Pathol 2000, 37:239-247.
    Search in Google Scholar
DOI: https://doi.org/10.2478/acve-2023-0037 | Journal eISSN: 1820-7448 | Journal ISSN: 0567-8315
Journal RSS Feed
Language: English
Page range: 486 - 501
Accepted on: Nov 14, 2023
Published on: Dec 14, 2023
Published by: University of Belgrade, Faculty of Veterinary Medicine
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
Acute phase proteins,
bitches,
electrophoresis,
mammary gland neoplasia,
serum proteins,
protein fractions
Related subjects:
Medicine,
Veterinary medicine

© 2023 Csilla Tóthová, Alexandra Valenčáková, Ľubica Horňáková, Oskar Nagy, published by University of Belgrade, Faculty of Veterinary Medicine
This work is licensed under the Creative Commons Attribution 4.0 License.

Previous articleVolume 73 (2023): Issue 4 (December 2023)Next article