Immunological and pathological investigations of non-specific reactive hepatitis in shelter dogs

Jose Raduan Jaber; Alicia S Velázquez-Wallraf; David Farray; Antonio G. Ravelo-García; Conrado Carrascosa; Myriam Rodríguez-Ventura; Jose Perez

doi:10.2478/acve-2019-0004

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Immunological and pathological investigations of non-specific reactive hepatitis in shelter dogs

Acta Veterinaria

Volume 69 (2019): Issue 1 (March 2019)

By: Jose Raduan Jaber, Alicia S Velázquez-Wallraf, David Farray, Antonio G. Ravelo-García, Conrado Carrascosa, Myriam Rodríguez-Ventura and Jose Perez

Open Access

|Mar 2019

Abstract

The aim of this study was to describe the gross, histopathological and immunohistochemical features of non-specific reactive hepatitis (NSRH) in stray dogs. To perform this study the livers of 23 dogs of different breed and sex were used. The tissue sections were stained with hematoxylin–eosin, and immunohistochemically. The results of this work showed that NSRH was characterized by the infiltration of lymphocytes and plasma cells scattered throughout the liver parenchyma and in the portal stroma, and associated with inflammatory and non-inflammatory diseases in other organ systems. The inflammatory infiltrate of NSRH was composed of CD3+ T lymphocytes and HLA-DR+ lymphocytes, as well as IgG+ plasma cells and alpha-1-antitrypsin+ macrophages in the portal spaces and hepatic sinusoids.

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Articles in this issue

DOI: https://doi.org/10.2478/acve-2019-0004 | Journal eISSN: 1820-7448 | Journal ISSN: 0567-8315

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Language: English

Page range: 61 - 72

Submitted on: Jan 5, 2019

Accepted on: Mar 5, 2019

Published on: Mar 29, 2019

Published by: University of Belgrade, Faculty of Veterinary Medicine

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

liver,

hepatitis,

immunohistochemistry,

dog

Related subjects:

Medicine,

Veterinary medicine

© 2019 Jose Raduan Jaber, Alicia S Velázquez-Wallraf, David Farray, Antonio G. Ravelo-García, Conrado Carrascosa, Myriam Rodríguez-Ventura, Jose Perez, published by University of Belgrade, Faculty of Veterinary Medicine
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Volume 69 (2019): Issue 1 (March 2019)