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Synergistic effect of piperine combined with luteolin on anti-non-small cell lung cancer activity in vitro and in LLC tumour-bearing mice: Mechanistic insights from network pharmacology and molecular docking Cover

Synergistic effect of piperine combined with luteolin on anti-non-small cell lung cancer activity in vitro and in LLC tumour-bearing mice: Mechanistic insights from network pharmacology and molecular docking

Open Access
|Jun 2026

Authors

Liangfeng Wang

School of Medicine, Anhui University of Science and Technology, Huainan, China
Key Laboratory of Industrial Dust Deep Reduction and Occupational Health and Safety of Anhui Higher Education Institutes, Huainan, China
Anhui Province Engineering Laboratory of Occupational Health and Safety Huainan, Anhui Province Engineering Laboratory of Occupational Health and Safety Huainan, China

Yuexing Chang

yxchang@aust.edu.cn

School of Medicine, Anhui University of Science and Technology, Huainan, China
Key Laboratory of Industrial Dust Deep Reduction and Occupational Health and Safety of Anhui Higher Education Institutes, Huainan, China
Anhui Province Engineering Laboratory of Occupational Health and Safety Huainan, Anhui Province Engineering Laboratory of Occupational Health and Safety Huainan, China
Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province Hainan Normal University, Haikou, China
Analytical and testing center, Anhui University of Science and Technology, Huainan, China

Yufeng Liu

School of Medicine, Anhui University of Science and Technology, Huainan, China
Key Laboratory of Industrial Dust Deep Reduction and Occupational Health and Safety of Anhui Higher Education Institutes, Huainan, China
Anhui Province Engineering Laboratory of Occupational Health and Safety Huainan, Anhui Province Engineering Laboratory of Occupational Health and Safety Huainan, China

Ailing Guo

School of Medicine, Anhui University of Science and Technology, Huainan, China
Key Laboratory of Industrial Dust Deep Reduction and Occupational Health and Safety of Anhui Higher Education Institutes, Huainan, China
Anhui Province Engineering Laboratory of Occupational Health and Safety Huainan, Anhui Province Engineering Laboratory of Occupational Health and Safety Huainan, China
Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province Hainan Normal University, Haikou, China

Baorong Wang

School of Medicine, Anhui University of Science and Technology, Huainan, China
Key Laboratory of Industrial Dust Deep Reduction and Occupational Health and Safety of Anhui Higher Education Institutes, Huainan, China
Anhui Province Engineering Laboratory of Occupational Health and Safety Huainan, Anhui Province Engineering Laboratory of Occupational Health and Safety Huainan, China

Feng Jin

School of Medicine, Anhui University of Science and Technology, Huainan, China
Key Laboratory of Industrial Dust Deep Reduction and Occupational Health and Safety of Anhui Higher Education Institutes, Huainan, China
Anhui Province Engineering Laboratory of Occupational Health and Safety Huainan, Anhui Province Engineering Laboratory of Occupational Health and Safety Huainan, China

Yun Deng

School of Medicine, Anhui University of Science and Technology, Huainan, China
Key Laboratory of Industrial Dust Deep Reduction and Occupational Health and Safety of Anhui Higher Education Institutes, Huainan, China
Anhui Province Engineering Laboratory of Occupational Health and Safety Huainan, Anhui Province Engineering Laboratory of Occupational Health and Safety Huainan, China
DOI: https://doi.org/10.2478/acph-2026-0015 | Journal eISSN: 1846-9558 | Journal ISSN: 1330-0075
Language: English
Page range: 1 - 26
Accepted on: May 25, 2026
Published on: Jun 30, 2026
In partnership with: Paradigm Publishing Services
Related subjects:

© 2026 Liangfeng Wang, Yuexing Chang, Yufeng Liu, Ailing Guo, Baorong Wang, Feng Jin, Yun Deng, published by Croatian Pharmaceutical Society
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.