References
- R. Nagpal, R. Mainali, S. Ahmadi, S. Wang, R. Singh, K. Kavanagh, D. W. Kitzman, A. Kushugulova, F. Marotta and H. Yadav, Gut microbiome and aging: Physiological and mechanistic insights, Nutr. Healthy Aging 4(4) (2018) 267–285; https://doi.org/10.3233/NHA-170030
- C. Franceschi, P. Garagnani, P. Parini, C. Giuliani and A. Santoro, Inflammaging: A new immune-metabolic viewpoint for age-related diseases, Nat. Rev. Endocrinol. 14 (2018) 576–590; https://doi.org/10.1038/s41574-018-0059-4
- T. W. Buford, (Dis)Trust your gut: The gut microbiome in age-related inflammation, health, and disease, Microbiome 5 (2017) Article ID 80 (11 pages); https://doi.org/10.1186/s40168-017-0296-0
- J. F. Cryan, K. J. O’Riordan, C. S. M. Cowan, K. V. Sandhu, T. F. S. Bastiaanssen, M. Boehme, M. G. Codagnone, S. Cussotto, C. Fulling, A. V. Golubeva, K. E. Guzzetta, M. Jaggar, C. M. Long-Smith, J. M. Lyte, J. A. Martin, A. Molinero-Perez, G. Moloney, E. Morelli, E. Morillas, R. O’Connor, J. S. Cruz-Pereira, V. L. Peterson, K. Rea, N. L. Ritz, E. Sherwin, S. Spichak, E. M. Teichman, M. van de Wouw, A. P. Ventura-Silva, S. E. Wallace-Fitzsimons, N. Hyland, G. Clarke and T. G. Dinan, The micrbiota-gut-brain axis, Physiol. Rev. 99(4) (2019) 1877–2013; https://doi.org/10.1152/physrev.00018.2018
- A. K. El-Ansary, A. B. Bacha and M. Kotb, Etiology of autistic features: The persisting neurotoxic effects of propionic acid, J. Neuroinflam. 9(1) (2012) Article ID 74 (14 pages); https://doi.org/10.1186/1742-2094-9-74
- A. Ishaq, A. N. Alabdali, M. Alonazi, A. A. Alzahrani, E. Al-Shehri and A. B. Bacha, Luteolin mitigates oxidative stress and multi-organ impairment in a propionic acid-induced rodent model of autism, Front. Nutr. 12 (2025) Article ID 1583119 (15 pages); https://doi.org/10.3389/fnut.2025.1583119
- A. K. El-Ansary, S. K. Al-Daihan and A. R. El-Gezeery, On the protective effect of omega-3 against propionic acid-induced neurotoxicity in rat pups, Lipids Health Dis. 10 (2011) Article ID 142 (15 pages); https://doi.org/10.1186/1476-511X-10-142
- P. C. Calder, Omega-3 fatty acids and inflammatory processes: From molecules to man, Biochem. Soc. Trans. 45(5) (2017) 1105–1115; https://doi.org/10.1042/BST20160474
- J. K. Kiecolt-Glaser, E. S. Epel, M. A. Belury, R. Andridge, J. Lin, R. Glaser, W. B. Malarkey, B. S. Hwang and E. Blackburn, Omega-3 fatty acids, oxidative stress, and leukocyte telomere length: A randomised controlled trial, Brain Behav. Immun. 28 (2013) 16–24; https://doi.org/10.1016/j.bbi.2012.09.004
- L. A. Durkin, C. E. Childs and P. C. Calder, Omega-3 polyunsaturated fatty acids and the intestinal epithelium – A review, Foods 10(1) (2021) Article ID 199 (35 pages); https://doi.org/10.3390/foods10010199
- N. Kamalmaz, A. Ben Bacha, M. Alonazi, G. Albasher, A. I. A. Khayyat and A. El-Ansary, Unveiling sex-based differences in developing propionic acid-induced features in mice as a rodent model of ASD, Peer J. 11 (2023) e15488 (26 pages); https://doi.org/10.7717/peerj.15488
- H. M. Abdou and M. A. Hassan, Protective role of omega-3 polyunsaturated fatty acid against lead acetate-induced toxicity in liver and kidney of female rats, BioMed Res. Int. 2014 (2014) Article ID 435857 (11 pages); https://doi.org/10.1155/2014/435857
- E. Nelissen, N. P. van Goethem, V. T. Bonassoli, P. R. A. Heckman, B. T. J. van Hagen, D. Suay, C. Wouters and J. Prickaerts, Validation of the xylazine/ketamine anesthesia test as a predictor of the emetic potential of pharmacological compounds in rats, Neurosci. Lett. 699 (2019) 41–46; https://doi.org/10.1016/j.neulet.2019.01.026
- M. B. Ruiz-Larrea, A. M. Leal, M. Liza, M. Lacort and H. de Groot, Antioxidant effects of estradiol and 2-hydroxyestradiol on iron-induced lipid peroxidation of rat liver microsomes, Steroids 59(6) (1994) 383–388; https://doi.org/10.1016/0039-128X(94)90006-X
- E. Beutler, Improved method for the determination of blood glutathione, J. Lab. Clin. Med. 61 (1963) 882–888.
- H. Cai, J. L. Caswell and J. F. Prescott, Nonculture molecular techniques for diagnosis of bacterial disease in animals: A diagnostic laboratory perspective, Vet. Pathol. 51(2) (2014) 341–351; https://doi.org/10.1177/0300985813511132
- D. Tellez, M. Balkenhol, N. Karssemeijer, G. Litjens, J. van der Laak and F. Ciompi, H and E stain augmentation improves generalization of convolutional networks for histopathological mitosis detection, Conf. Proceedings Vol. 10581: Medical Imaging 2018: Digital Pathology, 105810Z (2018); Conf. SPIE Medical Imaging, March 2018, Houston (TX, USA); https://doi.org/10.1117/12.2293048
- C. N. Serhan, Pro-resolving lipid mediators are leads for resolution physiology, Nature 510 (2014) 92–101; https://doi.org/10.1038/nature13479
- S. Layé, A. Nadjar, C. Joffre and R. P. Bazinet, Anti-inflammatory effects of omega-3 fatty acids in the brain: Physiological mechanisms and relevance to pharmacology, Pharmacol. Rev. 70(1) (2018) 12–38; https://doi.org/10.1124/pr.117.014092
- W. T. Kuo, L. Zuo, M. A. Odenwald, S. Madha, G. Singh, C. B. Gurniak, C. Abraham and J. R. Turner, The tight junction protein ZO-1 is dispensable for barrier function but critical for effective mucosal repair, Gastroenterology 161(6) (2021) 1924–1939; https://doi.org/10.1053/j.gastro.2021.08.047
- R. C. De Lisle, Disrupted tight junctions in the small intestine of cystic fibrosis mice, Cell Tissue Res. 355(1) (2013) 131–142; https://doi.org/10.1007/s00441-013-1734-3
- D. Camuesco, J. Gálvez, A. Nieto, M. Comalada, M.E. Rodríguez-Cabezas, A. Concha, J. Xaus and A. Zarzuelo, Dietary olive oil supplemented with fish oil, rich in EPA and DHA (n-3) polyunsatu-rated fatty acids, attenuates colonic inflammation in rats with DSS-induced colitis, J. Nutr. 135(4) (2005) 687–694; https://doi.org/10.1093/jn/135.4.687
- G. P. Zaloga, Narrative review of n-3 polyunsaturated fatty acid supplementation upon immune functions, resolution molecules and lipid peroxidation, Nutrients 13(2) (2021) Article ID 662 (30 pages); https://doi.org/10.3390/nu13020662
- R. P. Bazinet and S. Layé, Polyunsaturated fatty acids and their metabolites in brain function and disease, Nat. Rev. Neurosci. 15(12) (2014) 771–785; https://doi.org/10.1038/nrn3820
- S. Chalon, Omega-3 fatty acids and monoamine neurotransmission, PLEFA 75(4–5) (2006) 259–269; https://doi.org/10.1016/j.plefa.2006.07.005
- L. Costantini, R. Molinari, B. Farinon and N. Merendino, Impact of omega-3 fatty acids on the gut microbiota, Int. J. Mol. Sci. 18(12) (2017) Article ID 2645 (18 pages); https://doi.org/10.3390/ijms18122645
- E. Fock and R. Parnova, Mechanisms of blood-brain barrier protection by microbiota-derived short-chain fatty acids, Cells 12(4) (2023) Article ID 657 (29 pages); https://doi.org/10.3390/cells12040657
- B. Dalile, L. Van Oudenhove, B. Vervliet and K. Verbeke, The role of short-chain fatty acids in microbiota-gut-brain communication, Nat. Rev. Gastroenterol. Hepatol. 16(8) (2019) 461–478; https://doi.org/10.1038/s41575-019-0157-3
- N. S. Alsaqer, D. M. Al-Nouri, R. S. Bhat, S. Arzoo, L. N. Al-Harbi, M. A. Bin Obead, A. Y. Almubarak, H. Alkhalidi, A. Almotairi and A. K. E.-D. El-Ansary, Ameliorative effect of omega-3-rich fish diet on the neurotoxic effects of propionic acid in a rodent model of autism, Appl Sci. 13(13) (2023) Article ID 7392 (15 pages); https://doi.org/10.3390/app13137392
- J. Wang, B. Zheng, D. Zhou, J. Xing, H. Li, J. Li, Z. Zhang, B. Zhang and P. Li, Supplementation of diet with different n-3/n-6 PUFA ratios ameliorates autistic behavior, reduces serotonin, and improves intestinal barrier impairments in a valproic acid rat model of autism, Front. Psychiatry 11 (2020) Article ID 552345 (11 pages); https://doi.org/10.3389/fpsyt.2020.552345