References
- H. Sung, J. Ferlay, R. L. Siegel, M. Laversanne, I. Soerjomataram, A. Jemal and F. Bray, Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries, CA Cancer J. Clin. 71(3) (2021) 209–249; https://doi.org/10.3322/caac.21660
- A. K. Rustgi, The genetics of hereditary colon cancer, Genes Dev. 21 (2007) 2525–2538; https://doi.org/10.1101/gad.1593107
- Y. Dong, J. Zhou, Y. Zhu, L. Luo, T. He, H. Hu, H. Liu, Y. Zhang, D. Luo, S. Xu, L. Xu, J. Liu, J. Zhang and Z. Teng, Abdominal obesity and colorectal cancer risk: Systematic review and meta-analysis of prospective studies, Biosci. Rep. 37(6) (2017) Article ID BSR20170945 (19 pages); https://doi.org/10.1042/BSR20170945
- P. Ye, Y. Xi, Z. Huang and P. Xu, Linking obesity with colorectal cancer: Epidemiology and mechanistic insights, Cancers 12(6) (2020) Article ID 1408 (20 pages); https://doi.org/10.3390/cancers12061408
- P. H. Liu, K. Wu, K. Ng, A. G. Zauber, L. H. Nguyen, M. Song and Y. Cao, Association of obesity with risk of early-onset colorectal cancer among women, JAMA Oncol. 5(1) (2019) 37–44; https://doi.org/10.1001/jamaoncol.2018.4280
- T. Jess, C. Rungoe and L. Peyrin-Biroulet, Risk of colorectal cancer in patients with ulcerative colitis: A meta-analysis of population-based cohort studies, Clin. Gastroenterol. Hepatol. 10 (2012) 639–645; https://doi.org/10.1016/j.cgh.2012.01.010
- M. S. Nadeem, V. Kumar, F. A. Al-Abbasi, M. A. Kamal and F. Anwar, Risk of colorectal cancer in inflammatory bowel diseases, Semin. Cancer Biol. 64 (2020) 51–60; https://doi.org/10.1016/j.semcancer.2019.05.001
- E. Dekker, P. J. Tanis, J. L. Vleugels, P. M. Kasi and M. Wallace, Colorectal cancer, Lancet 394 (2019) 1467–1480; https://doi.org/10.1016/S0140-6736(19)32319-0
- M. G. Guren, The global challenge of colorectal cancer, Lancet Gastroenterol. Hepatol. 4 (2019) 894–895; https://doi.org/10.1016/S2468-1253(19)30329-2
- R. L. Siegel, K. D. Miller, A. Goding Sauer, S. A. Fedewa, L. F. Butterly, J. C. Anderson and A. Jemal, Colorectal cancer statistics, 2020, CA Cancer J. Clin. 70 (2020) 145–164; https://doi.org/10.3322/caac.21601
- N. Keum and E. Giovannucci, Global burden of colorectal cancer: Emerging trends, risk factors and prevention strategies, Nat. Rev. Gastroenterol. Hepatol. 16 (2019) 713–732; https://doi.org/10.1038/s41575-019-0189-8
- J. Guinney, R. Dienstmann, X. Wang, A. De Reynies, A. Schlicker, C. Soneson and S. Tejpar, The consensus molecular subtypes of colorectal cancer, Nat. Med. 21 (2015) 1350–1356; https://doi.org/10.1038/nm.3967
- S. Kopetz, A. Grothey and J. Tabernero, Encorafenib, binimetinib, and cetuximab in BRAF V600E-mutated colorectal cancer, N. Engl. J. Med. 382(9) (2020) 877–878; https://doi.org/10.1056/nejmc1915676 (Correspondence to the Editor)
- S. Kopetz, K. A. Guthrie, V. K. Morris, H. J. Lenz, A. M. Magliocco, D. Maru and H. S. Hochster, Randomized trial of irinotecan and cetuximab with or without vemurafenib in BRAF-mutant metastatic colorectal cancer (SWOG S1406), J. Clin. Oncol. 39 (2021) 285–294; https://doi.org/10.1200/JCO.20.01994
- M. Ekor, The growing use of herbal medicines: Issues relating to adverse reactions and challenges in monitoring safety, Front. Pharmacol. 4 (2014) Article ID 177 (10 pages); https://doi.org/10.3389/fphar.2013.00177
- A. Garcia-Alvarez, B. Egan, S. De Klein, L. Dima, F. M. Maggi, M. Isoniemi and L. Serra-Majem, Usage of plant food supplements across six European countries: Findings from the PlantLIBRA consumer survey, PLoS One 9 (2014) e92265 (18 pages); https://doi.org/10.1371/journal.pone.0092265
- A. S. van Wyk and G. Prinsloo, Health, safety and quality concerns of plant-based traditional medicines and herbal remedies, S. Afr. J. Bot. 133 (2020) 54–62; https://doi.org/10.1016/j.sajb.2020.06.031
- R. Kotecha, A. Takami and J. L. Espinoza, Dietary phytochemicals and cancer chemoprevention: A review of clinical evidence, Oncotarget 7 (2016) 52517–52529; https://doi.org/10.18632/oncotarget.9593
- Z. Liu, Z. Ren, J. Zhang, C. C. Chuang, E. Kandaswamy, T. Zhou and L. Zuo, Role of ROS and nutritional antioxidants in human diseases, Front. Physiol. 9 (2018) Article ID 477 (14 pages); https://doi.org/10.3389/fphys.2018.00477
- C. Tiffon, The impact of nutrition and environmental epigenetics on human health and disease, Int. J. Mol. Sci. 19(11) (2018) Article ID 3425 (19 pages); https://doi.org/10.3390/ijms19113425
- Y. Guo, Z. Y. Su and A. N. T. Kong, Current perspectives on epigenetic modifications by dietary chemopreventive and herbal phytochemicals, Curr. Pharmacol. Rep. 1 (2015) 245–257; https://doi.org/10.1007/s40495-015-0023-0
- M. Samec, A. Liskova, P. Kubatka, S. Uramova, P. Zubor, S. M. Samuel and D. Büsselberg, The role of dietary phytochemicals in the carcinogenesis via the modulation of miRNA expression, J. Cancer Res. Clin. Oncol. 145 (2019) 1665–1679; https://doi.org/10.1007/s00432-019-02940-0
- A. Everest and E. Ozturk, Focusing on the ethnobotanical uses of plants in Mersin and Adana provinces (Turkey), J. Ethnobiol. Ethnomed. 1 (2005) Article ID 6 (6 pages); https://doi.org/10.1186/1746-4269-1-6
- A. C. Gören, G. Topçu, G. Bilsel, M. Bilsel, Z. Aydoğmuş and J. M. Pezzuto, The chemical constituents and biological activity of essential oil of Lavandula stoechas ssp. stoechas, Z. Naturforsch. C 57 (2002) 797–800; https://doi.org/10.1515/znc-2002-9-1007
- F. Algieri, A. Rodriguez-Nogales, T. Vezza, J. Garrido-Mesa, N. Garrido-Mesa, M. P. Utrilla and J. Galvez, Anti-inflammatory activity of hydroalcoholic extracts of Lavandula dentata L. and Lavandula stoechas L., J. Ethnopharmacol. 190 (2016) 142–158; https://doi.org/10.1016/j.jep.2016.05.063
- T. Baytop, Therapy with Medicinal Plants in Turkey – Past and Present, 2nd ed., Nobel Kitap Evi, Istanbul 1999, pp. 284–285.
- M. N. Boukhatem, T. Sudha, N. H. E. Darwish, H. Chader, A. Belkadi, M. Rajabi, A. Houche, F. Benkebailli, F. Oudjida and S. A. Mousa, A new eucalyptol-rich lavender (Lavandula stoechas L.) essential oil: Emerging potential for therapy against inflammation and cancer, Molecules 25(16) (2020) Article 3671 (17 pages); https://doi.org/10.3390/molecules25163671
- L. S. Pimentel, L. M. Bastos, L. R. Goulart and L. N. D. M. Ribeiro, Therapeutic effects of essential oils and their bioactive compounds on prostate cancer treatment, Pharmaceutics 16(5) (2024) Article ID 583 (24 pages); https://doi.org/10.3390/pharmaceutics16050583
- H. M. Rasheed, U. Farooq, K. Bashir, F. Wahid, T. Khan, A. Khusro and M. U. K. Sahibzada, Isolation of oleanolic acid from Lavandula stoechas and its potent anticancer properties against MCF-7 cancer cells via induced apoptosis, J. King Saud Univ. Sci. 35 (2023) Article ID 102454 (11 pages); https://doi.org/10.1016/j.jksus.2022.102454
- L. Yu, M. M. Zhang and J. G. Hou, Molecular and cellular pathways in colorectal cancer: Apoptosis, autophagy and inflammation as key players, Scand. J. Gastroenterol. 57 (2022) 1279–1290; https://doi.org/10.1080/00365521.2022.2088247
- Y. Yilmaz and R. T. Toledo, Oxygen radical absorbance capacities of grape/wine industry byproducts and effect of solvent type on extraction of grape seed polyphenols, J. Food Comp. Anal. 19 (2006) 41–48; https://doi.org/10.1016/j.jfca.2004.10.009
- M. Pinelo, M. Rubilar, M. Jerez, J. Sineiro and M. J. Núñez, Effect of solvent, temperature, and solvent-to-solid ratio on the total phenolic content and antiradical activity of extracts from different components of grape pomace, J. Agric. Food Chem. 53 (2005) 2111–2117; https://doi.org/10.1021/jf0488110
- V. L. Singleton and J. A. Rossi, Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents, Am. J. Enol. Vitic. 16 (1965) 144–158; https://www.ajevonline.org/content/16/3/144
- E. Yilmaz, M. Ege, D. Misirli, G. D. Sonmez, O. Kilic and M. Elmastas, Phytochemical analysis, DNA barcoding and DNA protective activity of Ferulago cassia Boiss., Pak. J. Bot. 55 (2023) 2221–2229; https://doi.org/10.30848/PJB2023-6(31).
- S. Ataseven, D. Misirli, F. Uzar, N. N. Türkan and M. Elmastaş, Determination of phenolic compound composition of water and ethanol extracts of horsetail (Equisetum arvense), J. Integr. Anatol. Med. 2(2) (2021) 3–9.
- International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use, ICH Harmonised Guideline – Validation of Analytical Procedures Q2(R2), ICH, Geneva, November 2023
- A. Shrivastava and V. B. Gupta, Methods for the determination of limit of detection and limit of quantitation of the analytical methods, Chron. Young Sci. 2(1) (2011) 21–25; https://doi.org/10.4103/2229-5186.79345
- L. Z. Lambarki, F. Jhilal, L. Slimani, R. El Hajji, F. Bakkali, S. Iskandar, M. El Jemli, B. Ihssane, W. El Ghali and T. Saffaj, Comparison of approaches for assessing detection and quantitation limits in bioanalytical methods using HPLC for sotalol in plasma, Sci. Rep. 15 (2025) Article ID 5472 (12 pages); https://doi.org/10.1038/s41598-024-83474-5
- P. Prieto, M. Pineda and M. Aguilar, Spectrophotometric quantitation of antioxidant capacity through the formation of a phosphomolybdenum complex: Specific application to the determination of vitamin E, Anal. Biochem. 269 (1999) 337–341; https://doi.org/10.1006/abio.1999.4019
- E. Celep, S. Akyüz, Y. İnan and E. Yesilada, Assessment of potential bioavailability of major phenolic compounds in Lavandula stoechas L. ssp. stoechas, Ind. Crops Prod. 118 (2018) 111–117; https://doi.org/10.1016/j.indcrop.2018.03.041
- I. Spiridon, S. Colceru, N. Anghel, C. A. Teaca, R. Bodirlau and A. Armatu, Antioxidant capacity and total phenolic contents of oregano (Origanum vulgare), lavender (Lavandula angustifolia) and lemon balm (Melissa officinalis) from Romania, Nat. Prod. Res. 25 (2011) 1657–1661; https://doi.org/10.1080/14786419.2010.521502
- I. K. Karabagias, V. K. Karabagias and K. A. Riganakos, Physico-chemical parameters, phenolic profile, in vitro antioxidant activity and volatile compounds of ladastacho (Lavandula stoechas) from the region of Saidona, Antioxidants 8(4) (2019) Article ID 80 (16 pages); https://doi.org/10.3390/antiox8040080
- X. Dong, X. Li, X. Ruan, L. Kong, N. Wang, W. Gao and M. Jin, A deep insight into the structure-solubility relationship and molecular interaction mechanism of diverse flavonoids in molecular solvents, ionic liquids, and molecular solvent/ionic liquid mixtures, J. Mol. Liq. 385 (2023) Article ID 122359 (53 pages); https://doi.org/10.1016/j.molliq.2023.122359
- F. Laila, D. Fardiaz, N. D. Yuliana, M. R. M. Damanik and F. N. A. Dewi, Methanol extract of Coleus amboinicus (Lour) exhibited antiproliferative activity and induced programmed cell death in colon cancer cell WiDr, Int. J. Food Sci. 2020 (2020) Article ID 9068326 (12 pages); https://doi.org/10.1155/2020/9068326
- Y.-H. Lu, Y. Hong, T.-Y. Zhang, Y.-X. Chen, Z.-J. Wei and C.-Y. Gao, Rosmarinic acid exerts anti-inflammatory effect and relieves oxidative stress via Nrf2 activation in carbon tetrachloride- induced liver damage, Food Nutr. Res. 66 (2022) Article ID 8359 (13 pages); https://doi.org/10.29219/fnr.v66.8359
- Y.-G. Jang, K.-A. Hwang and K.-C. Choi, Rosmarinic acid, a component of rosemary tea, induced the cell cycle arrest and apoptosis through modulation of HDAC2 expression in prostate cancer cell lines, Nutrients 10(11) (2018) Article ID 1784 (15 pages); https://doi.org/10.3390/nu10111784
- J. Y. Kee, Y. H. Han, D. S. Kim, J. G. Mun, J. Park, M. Y. Jeong and S. H. Hong, Inhibitory effect of quercetin on colorectal lung metastasis through inducing apoptosis, and suppression of meta-static ability, Phytomedicine 23 (2016) 1680–1690; https://doi.org/10.1016/j.phymed.2016.09.011
- X.-A. Zhang, S. Zhang, Q. Yin and J. Zhang, Quercetin induces human colon cancer cells apoptosis by inhibiting the nuclear factor-kappa B pathway, Pharmacogn. Mag. 11(42) (2015) 404–409; https://doi.org/10.4103/0973-1296.153096
- M. Han, Y. Song and X. Zhang, Quercetin suppresses the migration and invasion in human colon cancer Caco-2 cells through regulating toll-like receptor 4/nuclear factor-kappa B pathway, Pharmacogn. Mag. 12(46s) (2016) s237–s244; https://doi.org/10.4103/0973-1296.182154
- Y. Ez Zoubi, D. Bousta, M. Lachkar and A. Farah, Antioxidant and anti-inflammatory properties of ethanolic extract of Lavandula stoechas L. from Taounate region in Morocco, Int. J. Phytopharm. 5 (2014) 21–26.
- A. Bouyahya, A. Et-Touys, J. Abrini, A. Talbaoui, H. Fellah, Y. Bakri and N. Dakka, Lavandula stoechas essential oil from Morocco as novel source of antileishmanial, antibacterial and antioxidant activities, Biocatal. Agric. Biotechnol. 12 (2017) 179–184; https://doi.org/10.1016/j.bcab.2017.10.003
- R. B. Badisa, O. Tzakou, M. Couladis and E. Pilarinou, Cytotoxic activities of some Greek Labiatae herbs, Phytother. Res. 17 (2003) 472–476; https://doi.org/10.1002/ptr.1175
- M. A. Siddiqui, H. H. Siddiqui, A. Mishra and A. Usmani, Evaluation of cytotoxic activity of Lavandula stoechas aerial parts fractions against HepG2 cell lines, Curr. Bioact. Compd. 16 (2020) 1281–1289; https://doi.org/10.2174/1573407215666190916102325
- M. Abotaleb, A. Liskova, P. Kubatka and D. Büsselberg, Therapeutic potential of plant phenolic acids in the treatment of cancer, Biomolecules 10(2) (2020) Article ID 221 (23 pages); https://doi.org/10.3390/biom10020221
- S. Jafari, S. Saeidnia and M. Abdollahi, Role of natural phenolic compounds in cancer chemoprevention via regulation of the cell cycle, Curr. Pharm. Biotechnol. 15 (2014) 409–421; https://doi.org/10.2174/1389201015666140813124832
- A. S. Y. Kong, S. Maran and H. S. Loh, Navigating the interplay between BCL-2 family proteins, apoptosis, and autophagy in colorectal cancer, Adv. Cancer Biol. Metastasis 11 (2024) Article ID 100126 (9 pages); https://doi.org/10.1016/j.acb.2024.100126
- N. Mehrotra, S. Kharbanda and H. Singh, BH3 mimetics in cancer therapy and their future perspectives with nanodelivery, Nanomedicine 16 (2021) 1067–1070; https://doi.org/10.2217/nnm-2021-0059
- F. Sakanashi, M. Shintani, M. Tsuneyoshi, H. Ohsaki and S. Kamoshida, Apoptosis, necroptosis and autophagy in colorectal cancer: Associations with tumor aggressiveness and p53 status, Pathol. Res. Pract. 215(7) (2019) Article ID 152425 (6 pages); https://doi.org/10.1016/j.prp.2019.04.017
- E. Gurpinar and K. H. Vousden, Hitting cancers’ weak spots: Vulnerabilities imposed by p53 mutation, Trends Cell Biol. 25 (2015) 486–495; https://doi.org/10.1016/j.tcb.2015.04.001
- M. C. Liebl and T. G. Hofmann, The role of p53 signaling in colorectal cancer, Cancers 13(9) (2021) Article ID 2125 (29 pages); https://doi.org/10.3390/cancers13092125
- Q. Hao, J. Chen, H. Lu and X. Zhou, The ARTS of p53-dependent mitochondrial apoptosis, J. Mol. Cell Biol. 14(10) (2022) Article ID mjac074 (8 pages); https://doi.org/10.1093/jmcb/mjac074
- E. Mojodi, S. K. Sabbagh, K. Shahamiri and M. Rajabi, Antitumor effect of lavender essential oil-synthesized nanoparticles against MCF7 and SKBR3 cancer cell lines: Cytotoxicity and gene expression analysis, Biomed. Res. Ther. 12 (2025) 7224–7235; https://doi.org/10.15419/bmrat.v12i3.965
- I. Malami, A. B. Abdul, R. Abdullah, N. K. B. Kassim, R. Rosli, S. K. Yeap and M. B. Bello, Crude extracts, flavokawain B and alpinetin compounds from the rhizome of Alpinia mutica induce cell death via UCK2 enzyme inhibition and in turn reduce 18S rRNA biosynthesis in HT-29 cells, PLoS One 12 (2017) e0170233 (19 pages); https://doi.org/10.1371/journal.pone.0170233
- G. Maitisha, M. Aimaiti, Z. An and X. Li, Allicin induces cell cycle arrest and apoptosis of breast cancer cells in vitro via modulating the p53 pathway, Mol. Biol. Rep. 48 (2021) 7261–7272; https://doi.org/10.1007/s11033-021-06722-1
- H. K. Permatasari, D. S. Wewengkang, N. I. Tertiana, F. Z. Muslim, M. Yusuf, S. O. Baliulina, V. P. A. Daud, A. A. Setiawan and F. Nurkolis, Anti-cancer properties of Caulerpa racemosa by altering expression of Bcl-2, BAX, cleaved caspase 3 and apoptosis in HeLa cancer cell culture, Front. Oncol. 12 (2022) Article ID 964816 (11 pages); https://doi.org/10.3389/fonc.2022.964816
- M. A. Mahmoud, T. M. Okda, G. A. Omran and M. M. Abd-Alhaseeb, Rosmarinic acid suppresses inflammation, angiogenesis, and improves paclitaxel induced apoptosis in a breast cancer model via NF-κB-p53-caspase-3 pathways modulation, J. Appl. Biomed. 19(4) (2021) 202–209; https://doi.org/10.32725/jab.2021.024
- P. Kadkhoda, A. R. Farimani, E. Chamani and S. M. Hashemi, Molecular mechanisms of HT-29 colorectal cancer cell death induced by Artemisia annua methanolic extract, Modern Care J. 22(2) (2024) e148090 (8 pages); https://doi.org/10.5812/mcj-148090
- B. Ku, C. Liang, J. U. Jung and B. H. Oh, Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX, Cell Res. 21 (2011) 627–641; https://doi.org/10.1038/cr.2010.149
- Z. Tayarani-Najaran, E. Hadipour, S. M. S. Mousavi, S. A. Emami, L. Mohtashami and B. Javadi, Protective effects of Lavandula stoechas L. methanol extract against 6-OHDA-induced apoptosis in PC12 cells, J. Ethnopharmacol. 273 (2021) Article ID 114023; https://doi.org/10.1016/j.jep.2021.114023