Have a personal or library account? Click to login
Anticancer activity of Lavandula stoechas L. flower ethanolic extract through apoptotic pathway modulation in colorectal cancer cells Cover

Anticancer activity of Lavandula stoechas L. flower ethanolic extract through apoptotic pathway modulation in colorectal cancer cells

Acta Pharmaceutica
Volume 75 (2025): Issue 3 (September 2025)
By:
Open Access
|Oct 2025

References

  1. H. Sung, J. Ferlay, R. L. Siegel, M. Laversanne, I. Soerjomataram, A. Jemal and F. Bray, Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries, <em>CA Cancer J. Clin</em>. <bold>71</bold>(3) (2021) 209–249; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.3322/caac.21660" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.3322/caac.21660</a>">https://doi.org/10.3322/caac.21660</ext-link>
    Search in Google ScholarBack to article
  2. A. K. Rustgi, The genetics of hereditary colon cancer, <em>Genes Dev</em>. <bold>21</bold> (2007) 2525–2538; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1101/gad.1593107" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1101/gad.1593107</a>">https://doi.org/10.1101/gad.1593107</ext-link>
    Search in Google ScholarBack to article
  3. Y. Dong, J. Zhou, Y. Zhu, L. Luo, T. He, H. Hu, H. Liu, Y. Zhang, D. Luo, S. Xu, L. Xu, J. Liu, J. Zhang and Z. Teng, Abdominal obesity and colorectal cancer risk: Systematic review and meta-analysis of prospective studies, <em>Biosci. Rep</em>. <bold>37</bold>(6) (2017) Article ID BSR20170945 (19 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1042/BSR20170945" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1042/BSR20170945</a>">https://doi.org/10.1042/BSR20170945</ext-link>
    Search in Google ScholarBack to article
  4. P. Ye, Y. Xi, Z. Huang and P. Xu, Linking obesity with colorectal cancer: Epidemiology and mechanistic insights, <em>Cancers</em> <bold>12</bold>(6) (2020) Article ID 1408 (20 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.3390/cancers12061408" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.3390/cancers12061408</a>">https://doi.org/10.3390/cancers12061408</ext-link>
    Search in Google ScholarBack to article
  5. P. H. Liu, K. Wu, K. Ng, A. G. Zauber, L. H. Nguyen, M. Song and Y. Cao, Association of obesity with risk of early-onset colorectal cancer among women, <em>JAMA Oncol</em>. <bold>5</bold>(1) (2019) 37–44; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1001/jamaoncol.2018.4280" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1001/jamaoncol.2018.4280</a>">https://doi.org/10.1001/jamaoncol.2018.4280</ext-link>
    Search in Google ScholarBack to article
  6. T. Jess, C. Rungoe and L. Peyrin-Biroulet, Risk of colorectal cancer in patients with ulcerative colitis: A meta-analysis of population-based cohort studies, <em>Clin. Gastroenterol. Hepatol</em>. <bold>10</bold> (2012) 639–645; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1016/j.cgh.2012.01.010" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1016/j.cgh.2012.01.010</a>">https://doi.org/10.1016/j.cgh.2012.01.010</ext-link>
    Search in Google ScholarBack to article
  7. M. S. Nadeem, V. Kumar, F. A. Al-Abbasi, M. A. Kamal and F. Anwar, Risk of colorectal cancer in inflammatory bowel diseases, <em>Semin. Cancer Biol.</em> <bold>64</bold> (2020) 51–60; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1016/j.semcancer.2019.05.001" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1016/j.semcancer.2019.05.001</a>">https://doi.org/10.1016/j.semcancer.2019.05.001</ext-link>
    Search in Google ScholarBack to article
  8. E. Dekker, P. J. Tanis, J. L. Vleugels, P. M. Kasi and M. Wallace, Colorectal cancer, <em>Lancet</em> <bold>394</bold> (2019) 1467–1480; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1016/S0140-6736(19)32319-0" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1016/S0140-6736(19)32319-0</a>">https://doi.org/10.1016/S0140-6736(19)32319-0</ext-link>
    Search in Google ScholarBack to article
  9. M. G. Guren, The global challenge of colorectal cancer, <em>Lancet Gastroenterol. Hepatol.</em> <bold>4</bold> (2019) 894–895; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1016/S2468-1253(19)30329-2" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1016/S2468-1253(19)30329-2</a>">https://doi.org/10.1016/S2468-1253(19)30329-2</ext-link>
    Search in Google ScholarBack to article
  10. R. L. Siegel, K. D. Miller, A. Goding Sauer, S. A. Fedewa, L. F. Butterly, J. C. Anderson and A. Jemal, Colorectal cancer statistics, 2020, <em>CA Cancer J. Clin.</em> <bold>70</bold> (2020) 145–164; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.3322/caac.21601" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.3322/caac.21601</a>">https://doi.org/10.3322/caac.21601</ext-link>
    Search in Google ScholarBack to article
  11. N. Keum and E. Giovannucci, Global burden of colorectal cancer: Emerging trends, risk factors and prevention strategies, <em>Nat. Rev. Gastroenterol. Hepatol.</em> <bold>16</bold> (2019) 713–732; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1038/s41575-019-0189-8" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1038/s41575-019-0189-8</a>">https://doi.org/10.1038/s41575-019-0189-8</ext-link>
    Search in Google ScholarBack to article
  12. J. Guinney, R. Dienstmann, X. Wang, A. De Reynies, A. Schlicker, C. Soneson and S. Tejpar, The consensus molecular subtypes of colorectal cancer, <em>Nat. Med.</em> <bold>21</bold> (2015) 1350–1356; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1038/nm.3967" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1038/nm.3967</a>">https://doi.org/10.1038/nm.3967</ext-link>
    Search in Google ScholarBack to article
  13. S. Kopetz, A. Grothey and J. Tabernero, Encorafenib, binimetinib, and cetuximab in BRAF V600E-mutated colorectal cancer, <em>N. Engl. J. Med.</em> <bold>382</bold>(9) (2020) 877–878; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1056/nejmc1915676" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1056/nejmc1915676</a>">https://doi.org/10.1056/nejmc1915676</ext-link> (Correspondence to the Editor)
    Search in Google ScholarBack to article
  14. S. Kopetz, K. A. Guthrie, V. K. Morris, H. J. Lenz, A. M. Magliocco, D. Maru and H. S. Hochster, Randomized trial of irinotecan and cetuximab with or without vemurafenib in BRAF-mutant metastatic colorectal cancer (SWOG S1406), <em>J. Clin. Oncol.</em> <bold>39</bold> (2021) 285–294; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1200/JCO.20.01994" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1200/JCO.20.01994</a>">https://doi.org/10.1200/JCO.20.01994</ext-link>
    Search in Google ScholarBack to article
  15. M. Ekor, The growing use of herbal medicines: Issues relating to adverse reactions and challenges in monitoring safety, <em>Front. Pharmacol.</em> <bold>4</bold> (2014) Article ID 177 (10 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.3389/fphar.2013.00177" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.3389/fphar.2013.00177</a>">https://doi.org/10.3389/fphar.2013.00177</ext-link>
    Search in Google ScholarBack to article
  16. A. Garcia-Alvarez, B. Egan, S. De Klein, L. Dima, F. M. Maggi, M. Isoniemi and L. Serra-Majem, Usage of plant food supplements across six European countries: Findings from the PlantLIBRA consumer survey, <em>PLoS One</em> <bold>9</bold> (2014) e92265 (18 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1371/journal.pone.0092265" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1371/journal.pone.0092265</a>">https://doi.org/10.1371/journal.pone.0092265</ext-link>
    Search in Google ScholarBack to article
  17. A. S. van Wyk and G. Prinsloo, Health, safety and quality concerns of plant-based traditional medicines and herbal remedies, <em>S. Afr. J. Bot.</em> <bold>133</bold> (2020) 54–62; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1016/j.sajb.2020.06.031" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1016/j.sajb.2020.06.031</a>">https://doi.org/10.1016/j.sajb.2020.06.031</ext-link>
    Search in Google ScholarBack to article
  18. R. Kotecha, A. Takami and J. L. Espinoza, Dietary phytochemicals and cancer chemoprevention: A review of clinical evidence, <em>Oncotarget</em> <bold>7</bold> (2016) 52517–52529; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.18632/oncotarget.9593" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.18632/oncotarget.9593</a>">https://doi.org/10.18632/oncotarget.9593</ext-link>
    Search in Google ScholarBack to article
  19. Z. Liu, Z. Ren, J. Zhang, C. C. Chuang, E. Kandaswamy, T. Zhou and L. Zuo, Role of ROS and nutritional antioxidants in human diseases, <em>Front. Physiol.</em> <bold>9</bold> (2018) Article ID 477 (14 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.3389/fphys.2018.00477" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.3389/fphys.2018.00477</a>">https://doi.org/10.3389/fphys.2018.00477</ext-link>
    Search in Google ScholarBack to article
  20. C. Tiffon, The impact of nutrition and environmental epigenetics on human health and disease, <em>Int. J. Mol. Sci.</em> <bold>19</bold>(11) (2018) Article ID 3425 (19 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.3390/ijms19113425" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.3390/ijms19113425</a>">https://doi.org/10.3390/ijms19113425</ext-link>
    Search in Google ScholarBack to article
  21. Y. Guo, Z. Y. Su and A. N. T. Kong, Current perspectives on epigenetic modifications by dietary chemopreventive and herbal phytochemicals, <em>Curr. Pharmacol. Rep.</em> <bold>1</bold> (2015) 245–257; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1007/s40495-015-0023-0" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1007/s40495-015-0023-0</a>">https://doi.org/10.1007/s40495-015-0023-0</ext-link>
    Search in Google ScholarBack to article
  22. M. Samec, A. Liskova, P. Kubatka, S. Uramova, P. Zubor, S. M. Samuel and D. Büsselberg, The role of dietary phytochemicals in the carcinogenesis via the modulation of miRNA expression, <em>J. Cancer Res. Clin. Oncol.</em> <bold>145</bold> (2019) 1665–1679; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1007/s00432-019-02940-0" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1007/s00432-019-02940-0</a>">https://doi.org/10.1007/s00432-019-02940-0</ext-link>
    Search in Google ScholarBack to article
  23. A. Everest and E. Ozturk, Focusing on the ethnobotanical uses of plants in Mersin and Adana provinces (Turkey), <em>J. Ethnobiol. Ethnomed.</em> <bold>1</bold> (2005) Article ID 6 (6 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1186/1746-4269-1-6" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1186/1746-4269-1-6</a>">https://doi.org/10.1186/1746-4269-1-6</ext-link>
    Search in Google ScholarBack to article
  24. A. C. Gören, G. Topçu, G. Bilsel, M. Bilsel, Z. Aydoğmuş and J. M. Pezzuto, The chemical constituents and biological activity of essential oil of <em>Lavandula stoechas</em> ssp. <em>stoechas</em>, <em>Z. Naturforsch. C</em> <bold>57</bold> (2002) 797–800; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1515/znc-2002-9-1007" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1515/znc-2002-9-1007</a>">https://doi.org/10.1515/znc-2002-9-1007</ext-link>
    Search in Google ScholarBack to article
  25. F. Algieri, A. Rodriguez-Nogales, T. Vezza, J. Garrido-Mesa, N. Garrido-Mesa, M. P. Utrilla and J. Galvez, Anti-inflammatory activity of hydroalcoholic extracts of <em>Lavandula dentata</em> L. and <em>Lavandula stoechas</em> L., <em>J. Ethnopharmacol.</em> <bold>190</bold> (2016) 142–158; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1016/j.jep.2016.05.063" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1016/j.jep.2016.05.063</a>">https://doi.org/10.1016/j.jep.2016.05.063</ext-link>
    Search in Google ScholarBack to article
  26. T. Baytop, <em>Therapy with Medicinal Plants in Turkey – Past and Present</em>, 2<sup>nd</sup> ed., Nobel Kitap Evi, Istanbul 1999, pp. 284–285.
    Search in Google ScholarBack to article
  27. M. N. Boukhatem, T. Sudha, N. H. E. Darwish, H. Chader, A. Belkadi, M. Rajabi, A. Houche, F. Benkebailli, F. Oudjida and S. A. Mousa, A new eucalyptol-rich lavender (<em>Lavandula stoecha</em>s L.) essential oil: Emerging potential for therapy against inflammation and cancer, <em>Molecules</em> <bold>25</bold>(16) (2020) Article 3671 (17 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.3390/molecules25163671" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.3390/molecules25163671</a>">https://doi.org/10.3390/molecules25163671</ext-link>
    Search in Google ScholarBack to article
  28. L. S. Pimentel, L. M. Bastos, L. R. Goulart and L. N. D. M. Ribeiro, Therapeutic effects of essential oils and their bioactive compounds on prostate cancer treatment, <em>Pharmaceutics</em> <bold>16</bold>(5) (2024) Article ID 583 (24 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.3390/pharmaceutics16050583" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.3390/pharmaceutics16050583</a>">https://doi.org/10.3390/pharmaceutics16050583</ext-link>
    Search in Google ScholarBack to article
  29. H. M. Rasheed, U. Farooq, K. Bashir, F. Wahid, T. Khan, A. Khusro and M. U. K. Sahibzada, Isolation of oleanolic acid from <em>Lavandula stoechas</em> and its potent anticancer properties against MCF-7 cancer cells via induced apoptosis, <em>J. King Saud Univ. Sci.</em> <bold>35</bold> (2023) Article ID 102454 (11 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1016/j.jksus.2022.102454" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1016/j.jksus.2022.102454</a>">https://doi.org/10.1016/j.jksus.2022.102454</ext-link>
    Search in Google ScholarBack to article
  30. L. Yu, M. M. Zhang and J. G. Hou, Molecular and cellular pathways in colorectal cancer: Apoptosis, autophagy and inflammation as key players, <em>Scand. J. Gastroenterol.</em> <bold>57</bold> (2022) 1279–1290; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1080/00365521.2022.2088247" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1080/00365521.2022.2088247</a>">https://doi.org/10.1080/00365521.2022.2088247</ext-link>
    Search in Google ScholarBack to article
  31. Y. Yilmaz and R. T. Toledo, Oxygen radical absorbance capacities of grape/wine industry byproducts and effect of solvent type on extraction of grape seed polyphenols, <em>J. Food Comp. Anal.</em> <bold>19</bold> (2006) 41–48; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1016/j.jfca.2004.10.009" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1016/j.jfca.2004.10.009</a>">https://doi.org/10.1016/j.jfca.2004.10.009</ext-link>
    Search in Google ScholarBack to article
  32. M. Pinelo, M. Rubilar, M. Jerez, J. Sineiro and M. J. Núñez, Effect of solvent, temperature, and solvent-to-solid ratio on the total phenolic content and antiradical activity of extracts from different components of grape pomace, <em>J. Agric. Food Chem.</em> <bold>53</bold> (2005) 2111–2117; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1021/jf0488110" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1021/jf0488110</a>">https://doi.org/10.1021/jf0488110</ext-link>
    Search in Google ScholarBack to article
  33. V. L. Singleton and J. A. Rossi, Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents, <em>Am. J. Enol. Vitic.</em> <bold>16</bold> (1965) 144–158; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="https://www.ajevonline.org/content/16/3/144">https://www.ajevonline.org/content/16/3/144</ext-link>
    Search in Google ScholarBack to article
  34. E. Yilmaz, M. Ege, D. Misirli, G. D. Sonmez, O. Kilic and M. Elmastas, Phytochemical analysis, DNA barcoding and DNA protective activity of <em>Ferulago cassia</em> Boiss., <em>Pak. J. Bot.</em> <bold>55</bold> (2023) 2221–2229; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.30848/PJB2023-6(31)" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.30848/PJB2023-6(31)</a>">https://doi.org/10.30848/PJB2023-6(31)</ext-link>.
    Search in Google ScholarBack to article
  35. S. Ataseven, D. Misirli, F. Uzar, N. N. Türkan and M. Elmastaş, Determination of phenolic compound composition of water and ethanol extracts of horsetail (<em>Equisetum arvense</em>), <em>J. Integr. Anatol. Med.</em> <bold>2</bold>(2) (2021) 3–9.
    Search in Google ScholarBack to article
  36. International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use, <em>ICH Harmonised Guideline – Validation of Analytical Procedures Q2(R2)</em>, ICH, Geneva, November 2023
    Search in Google ScholarBack to article
  37. A. Shrivastava and V. B. Gupta, Methods for the determination of limit of detection and limit of quantitation of the analytical methods, <em>Chron. Young Sci.</em> <bold>2</bold>(1) (2011) 21–25; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.4103/2229-5186.79345" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.4103/2229-5186.79345</a>">https://doi.org/10.4103/2229-5186.79345</ext-link>
    Search in Google ScholarBack to article
  38. L. Z. Lambarki, F. Jhilal, L. Slimani, R. El Hajji, F. Bakkali, S. Iskandar, M. El Jemli, B. Ihssane, W. El Ghali and T. Saffaj, Comparison of approaches for assessing detection and quantitation limits in bioanalytical methods using HPLC for sotalol in plasma, <em>Sci. Rep.</em> <bold>15</bold> (2025) Article ID 5472 (12 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1038/s41598-024-83474-5" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1038/s41598-024-83474-5</a>">https://doi.org/10.1038/s41598-024-83474-5</ext-link>
    Search in Google ScholarBack to article
  39. P. Prieto, M. Pineda and M. Aguilar, Spectrophotometric quantitation of antioxidant capacity through the formation of a phosphomolybdenum complex: Specific application to the determination of vitamin E, <em>Anal. Biochem.</em> <bold>269</bold> (1999) 337–341; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1006/abio.1999.4019" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1006/abio.1999.4019</a>">https://doi.org/10.1006/abio.1999.4019</ext-link>
    Search in Google ScholarBack to article
  40. E. Celep, S. Akyüz, Y. İnan and E. Yesilada, Assessment of potential bioavailability of major phenolic compounds in <em>Lavandula stoechas</em> L. ssp. <em>stoechas</em>, <em>Ind. Crops Prod.</em> <bold>118</bold> (2018) 111–117; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1016/j.indcrop.2018.03.041" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1016/j.indcrop.2018.03.041</a>">https://doi.org/10.1016/j.indcrop.2018.03.041</ext-link>
    Search in Google ScholarBack to article
  41. I. Spiridon, S. Colceru, N. Anghel, C. A. Teaca, R. Bodirlau and A. Armatu, Antioxidant capacity and total phenolic contents of oregano (<em>Origanum vulgare</em>), lavender (<em>Lavandula angustifolia</em>) and lemon balm (<em>Melissa officinalis</em>) from Romania, <em>Nat. Prod. Res.</em> <bold>25</bold> (2011) 1657–1661; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1080/14786419.2010.521502" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1080/14786419.2010.521502</a>">https://doi.org/10.1080/14786419.2010.521502</ext-link>
    Search in Google ScholarBack to article
  42. I. K. Karabagias, V. K. Karabagias and K. A. Riganakos, Physico-chemical parameters, phenolic profile, in vitro antioxidant activity and volatile compounds of ladastacho (<em>Lavandula stoechas</em>) from the region of Saidona, <em>Antioxidants</em> <bold>8</bold>(4) (2019) Article ID 80 (16 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.3390/antiox8040080" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.3390/antiox8040080</a>">https://doi.org/10.3390/antiox8040080</ext-link>
    Search in Google ScholarBack to article
  43. X. Dong, X. Li, X. Ruan, L. Kong, N. Wang, W. Gao and M. Jin, A deep insight into the structure-solubility relationship and molecular interaction mechanism of diverse flavonoids in molecular solvents, ionic liquids, and molecular solvent/ionic liquid mixtures, <em>J. Mol. Liq</em>. <bold>385</bold> (2023) Article ID 122359 (53 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1016/j.molliq.2023.122359" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1016/j.molliq.2023.122359</a>">https://doi.org/10.1016/j.molliq.2023.122359</ext-link>
    Search in Google ScholarBack to article
  44. F. Laila, D. Fardiaz, N. D. Yuliana, M. R. M. Damanik and F. N. A. Dewi, Methanol extract of <em>Coleus amboinicus</em> (Lour) exhibited antiproliferative activity and induced programmed cell death in colon cancer cell WiDr, <em>Int. J. Food Sci.</em> <bold>2020</bold> (2020) Article ID 9068326 (12 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1155/2020/9068326" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1155/2020/9068326</a>">https://doi.org/10.1155/2020/9068326</ext-link>
    Search in Google ScholarBack to article
  45. Y.-H. Lu, Y. Hong, T.-Y. Zhang, Y.-X. Chen, Z.-J. Wei and C.-Y. Gao, Rosmarinic acid exerts anti-inflammatory effect and relieves oxidative stress via Nrf2 activation in carbon tetrachloride- induced liver damage, <em>Food Nutr. Res.</em> <bold>66</bold> (2022) Article ID 8359 (13 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.29219/fnr.v66.8359" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.29219/fnr.v66.8359</a>">https://doi.org/10.29219/fnr.v66.8359</ext-link>
    Search in Google ScholarBack to article
  46. Y.-G. Jang, K.-A. Hwang and K.-C. Choi, Rosmarinic acid, a component of rosemary tea, induced the cell cycle arrest and apoptosis through modulation of HDAC2 expression in prostate cancer cell lines, <em>Nutrients</em> <bold>10</bold>(11) (2018) Article ID 1784 (15 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.3390/nu10111784" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.3390/nu10111784</a>">https://doi.org/10.3390/nu10111784</ext-link>
    Search in Google ScholarBack to article
  47. J. Y. Kee, Y. H. Han, D. S. Kim, J. G. Mun, J. Park, M. Y. Jeong and S. H. Hong, Inhibitory effect of quercetin on colorectal lung metastasis through inducing apoptosis, and suppression of meta-static ability, <em>Phytomedicine</em> <bold>23</bold> (2016) 1680–1690; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1016/j.phymed.2016.09.011" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1016/j.phymed.2016.09.011</a>">https://doi.org/10.1016/j.phymed.2016.09.011</ext-link>
    Search in Google ScholarBack to article
  48. X.-A. Zhang, S. Zhang, Q. Yin and J. Zhang, Quercetin induces human colon cancer cells apoptosis by inhibiting the nuclear factor-kappa B pathway, <em>Pharmacogn. Mag.</em> <bold>11</bold>(42) (2015) 404–409; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.4103/0973-1296.153096" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.4103/0973-1296.153096</a>">https://doi.org/10.4103/0973-1296.153096</ext-link>
    Search in Google ScholarBack to article
  49. M. Han, Y. Song and X. Zhang, Quercetin suppresses the migration and invasion in human colon cancer Caco-2 cells through regulating toll-like receptor 4/nuclear factor-kappa B pathway, <em>Pharmacogn. Mag.</em> <bold>12</bold>(46s) (2016) s237–s244; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.4103/0973-1296.182154" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.4103/0973-1296.182154</a>">https://doi.org/10.4103/0973-1296.182154</ext-link>
    Search in Google ScholarBack to article
  50. Y. Ez Zoubi, D. Bousta, M. Lachkar and A. Farah, Antioxidant and anti-inflammatory properties of ethanolic extract of <em>Lavandula stoechas</em> L. from Taounate region in Morocco, <em>Int. J. Phytopharm.</em> <bold>5</bold> (2014) 21–26.
    Search in Google ScholarBack to article
  51. A. Bouyahya, A. Et-Touys, J. Abrini, A. Talbaoui, H. Fellah, Y. Bakri and N. Dakka, <em>Lavandula stoechas</em> essential oil from Morocco as novel source of antileishmanial, antibacterial and antioxidant activities, <em>Biocatal. Agric. Biotechnol.</em> <bold>12</bold> (2017) 179–184; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1016/j.bcab.2017.10.003" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1016/j.bcab.2017.10.003</a>">https://doi.org/10.1016/j.bcab.2017.10.003</ext-link>
    Search in Google ScholarBack to article
  52. R. B. Badisa, O. Tzakou, M. Couladis and E. Pilarinou, Cytotoxic activities of some Greek Labiatae herbs, <em>Phytother. Res.</em> <bold>17</bold> (2003) 472–476; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1002/ptr.1175" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1002/ptr.1175</a>">https://doi.org/10.1002/ptr.1175</ext-link>
    Search in Google ScholarBack to article
  53. M. A. Siddiqui, H. H. Siddiqui, A. Mishra and A. Usmani, Evaluation of cytotoxic activity of <em>Lavandula stoechas</em> aerial parts fractions against HepG2 cell lines, <em>Curr. Bioact. Compd.</em> <bold>16</bold> (2020) 1281–1289; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.2174/1573407215666190916102325" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.2174/1573407215666190916102325</a>">https://doi.org/10.2174/1573407215666190916102325</ext-link>
    Search in Google ScholarBack to article
  54. M. Abotaleb, A. Liskova, P. Kubatka and D. Büsselberg, Therapeutic potential of plant phenolic acids in the treatment of cancer, <em>Biomolecules</em> <bold>10</bold>(2) (2020) Article ID 221 (23 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.3390/biom10020221" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.3390/biom10020221</a>">https://doi.org/10.3390/biom10020221</ext-link>
    Search in Google ScholarBack to article
  55. S. Jafari, S. Saeidnia and M. Abdollahi, Role of natural phenolic compounds in cancer chemoprevention via regulation of the cell cycle, <em>Curr. Pharm. Biotechnol.</em> <bold>15</bold> (2014) 409–421; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.2174/1389201015666140813124832" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.2174/1389201015666140813124832</a>">https://doi.org/10.2174/1389201015666140813124832</ext-link>
    Search in Google ScholarBack to article
  56. A. S. Y. Kong, S. Maran and H. S. Loh, Navigating the interplay between BCL-2 family proteins, apoptosis, and autophagy in colorectal cancer, <em>Adv. Cancer Biol. Metastasis</em> <bold>11</bold> (2024) Article ID 100126 (9 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1016/j.acb.2024.100126" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1016/j.acb.2024.100126</a>">https://doi.org/10.1016/j.acb.2024.100126</ext-link>
    Search in Google ScholarBack to article
  57. N. Mehrotra, S. Kharbanda and H. Singh, BH3 mimetics in cancer therapy and their future perspectives with nanodelivery, <em>Nanomedicine</em> <bold>16</bold> (2021) 1067–1070; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.2217/nnm-2021-0059" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.2217/nnm-2021-0059</a>">https://doi.org/10.2217/nnm-2021-0059</ext-link>
    Search in Google ScholarBack to article
  58. F. Sakanashi, M. Shintani, M. Tsuneyoshi, H. Ohsaki and S. Kamoshida, Apoptosis, necroptosis and autophagy in colorectal cancer: Associations with tumor aggressiveness and p53 status, <em>Pathol. Res. Pract.</em> <bold>215</bold>(7) (2019) Article ID 152425 (6 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1016/j.prp.2019.04.017" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1016/j.prp.2019.04.017</a>">https://doi.org/10.1016/j.prp.2019.04.017</ext-link>
    Search in Google ScholarBack to article
  59. E. Gurpinar and K. H. Vousden, Hitting cancers’ weak spots: Vulnerabilities imposed by p53 mutation, <em>Trends Cell Biol.</em> <bold>25</bold> (2015) 486–495; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1016/j.tcb.2015.04.001" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1016/j.tcb.2015.04.001</a>">https://doi.org/10.1016/j.tcb.2015.04.001</ext-link>
    Search in Google ScholarBack to article
  60. M. C. Liebl and T. G. Hofmann, The role of p53 signaling in colorectal cancer, <em>Cancers</em> <bold>13</bold>(9) (2021) Article ID 2125 (29 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.3390/cancers13092125" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.3390/cancers13092125</a>">https://doi.org/10.3390/cancers13092125</ext-link>
    Search in Google ScholarBack to article
  61. Q. Hao, J. Chen, H. Lu and X. Zhou, The ARTS of p53-dependent mitochondrial apoptosis, <em>J. Mol. Cell Biol.</em> <bold>14</bold>(10) (2022) Article ID mjac074 (8 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1093/jmcb/mjac074" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1093/jmcb/mjac074</a>">https://doi.org/10.1093/jmcb/mjac074</ext-link>
    Search in Google ScholarBack to article
  62. E. Mojodi, S. K. Sabbagh, K. Shahamiri and M. Rajabi, Antitumor effect of lavender essential oil-synthesized nanoparticles against MCF7 and SKBR3 cancer cell lines: Cytotoxicity and gene expression analysis, <em>Biomed. Res. Ther.</em> <bold>12</bold> (2025) 7224–7235; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.15419/bmrat.v12i3.965" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.15419/bmrat.v12i3.965</a>">https://doi.org/10.15419/bmrat.v12i3.965</ext-link>
    Search in Google ScholarBack to article
  63. I. Malami, A. B. Abdul, R. Abdullah, N. K. B. Kassim, R. Rosli, S. K. Yeap and M. B. Bello, Crude extracts, flavokawain B and alpinetin compounds from the rhizome of <em>Alpinia mutica</em> induce cell death via UCK2 enzyme inhibition and in turn reduce 18S rRNA biosynthesis in HT-29 cells, <em>PLoS One</em> <bold>12</bold> (2017) e0170233 (19 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1371/journal.pone.0170233" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1371/journal.pone.0170233</a>">https://doi.org/10.1371/journal.pone.0170233</ext-link>
    Search in Google ScholarBack to article
  64. G. Maitisha, M. Aimaiti, Z. An and X. Li, Allicin induces cell cycle arrest and apoptosis of breast cancer cells in vitro via modulating the p53 pathway, <em>Mol. Biol. Rep.</em> <bold>48</bold> (2021) 7261–7272; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1007/s11033-021-06722-1" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1007/s11033-021-06722-1</a>">https://doi.org/10.1007/s11033-021-06722-1</ext-link>
    Search in Google ScholarBack to article
  65. H. K. Permatasari, D. S. Wewengkang, N. I. Tertiana, F. Z. Muslim, M. Yusuf, S. O. Baliulina, V. P. A. Daud, A. A. Setiawan and F. Nurkolis, Anti-cancer properties of <em>Caulerpa racemosa</em> by altering expression of Bcl-2, BAX, cleaved caspase 3 and apoptosis in HeLa cancer cell culture, <em>Front. Oncol.</em> <bold>12</bold> (2022) Article ID 964816 (11 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.3389/fonc.2022.964816" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.3389/fonc.2022.964816</a>">https://doi.org/10.3389/fonc.2022.964816</ext-link>
    Search in Google ScholarBack to article
  66. M. A. Mahmoud, T. M. Okda, G. A. Omran and M. M. Abd-Alhaseeb, Rosmarinic acid suppresses inflammation, angiogenesis, and improves paclitaxel induced apoptosis in a breast cancer model via NF-κB-p53-caspase-3 pathways modulation, <em>J. Appl. Biomed.</em> <bold>19</bold>(4) (2021) 202–209; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.32725/jab.2021.024" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.32725/jab.2021.024</a>">https://doi.org/10.32725/jab.2021.024</ext-link>
    Search in Google ScholarBack to article
  67. P. Kadkhoda, A. R. Farimani, E. Chamani and S. M. Hashemi, Molecular mechanisms of HT-29 colorectal cancer cell death induced by <em>Artemisia annua</em> methanolic extract, <em>Modern Care J.</em> <bold>22</bold>(2) (2024) e148090 (8 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.5812/mcj-148090" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.5812/mcj-148090</a>">https://doi.org/10.5812/mcj-148090</ext-link>
    Search in Google ScholarBack to article
  68. B. Ku, C. Liang, J. U. Jung and B. H. Oh, Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX, <em>Cell Res.</em> <bold>21</bold> (2011) 627–641; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1038/cr.2010.149" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1038/cr.2010.149</a>">https://doi.org/10.1038/cr.2010.149</ext-link>
    Search in Google ScholarBack to article
  69. Z. Tayarani-Najaran, E. Hadipour, S. M. S. Mousavi, S. A. Emami, L. Mohtashami and B. Javadi, Protective effects of <em>Lavandula stoechas</em> L. methanol extract against 6-OHDA-induced apoptosis in PC12 cells, <em>J. Ethnopharmacol.</em> <bold>273</bold> (2021) Article ID 114023; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1016/j.jep.2021.114023" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1016/j.jep.2021.114023</a>">https://doi.org/10.1016/j.jep.2021.114023</ext-link>
    Search in Google ScholarBack to article
DOI: https://doi.org/10.2478/acph-2025-0034 | Journal eISSN: 1846-9558 | Journal ISSN: 1330-0075
Journal RSS Feed
Language: English
Page range: 449 - 468
Accepted on: Sep 22, 2025
Published on: Oct 10, 2025
Published by: Croatian Pharmaceutical Society
In partnership with: Paradigm Publishing Services
Publication frequency: 4 times per year
Keywords:
flowers,
colorectal cancer,
phenolic compounds,
apoptosis,
HT-29,
TP53,
CASP3
Related subjects:
Pharmacy,
Pharmacy, other

© 2025 Zeynep Doğru, Mustafa Selim Doğru, Gamze Yeşilay, Özgecan Kayalar, Mahfuz Elmastaş, published by Croatian Pharmaceutical Society
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Previous articleVolume 75 (2025): Issue 3 (September 2025)Next article