Have a personal or library account? Click to login
Chemometrically-supported quality assessment of chamomile tea Cover

Chemometrically-supported quality assessment of chamomile tea

Acta Pharmaceutica
Volume 75 (2025): Issue 3 (September 2025)
By:
Open Access
|Oct 2025

References

  1. B. Blažeković and G. Stanić, Ispitivanje bioaktivnog sastava kamilice (<em>Matricaria recutita</em> L.) metodom tankoslojne kromatografije, <em>Farm. Glas.</em> <bold>60</bold> (2004) 243–254.
    Search in Google ScholarBack to article
  2. J. K. Srivastava, E. Shankar and S. Gupta, Chamomile: A herbal medicine of the past with bright future, <em>Mol. Med. Rep.</em> <bold>3</bold>(6) (2010) 895–901; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.3892/mmr.2010.377" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.3892/mmr.2010.377</a>">https://doi.org/10.3892/mmr.2010.377</ext-link>
    Search in Google ScholarBack to article
  3. M. M. El Joumaa and J. M. Borjac, <em>Matricaria chamomilla</em>: A valuable insight into recent advances in medicinal uses and pharmacological activities, <em>Phytochem. Rev.</em> <bold>21</bold> (2022) 1913–1940; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1007/s11101-022-09817-0" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1007/s11101-022-09817-0</a>">https://doi.org/10.1007/s11101-022-09817-0</ext-link>
    Search in Google ScholarBack to article
  4. M. Sánchez, E. González-Burgos and M. P. Gómez-Serranillos, The pharmacology and clinical efficacy of <em>Matricaria recutita</em> L.: A systematic review of <em>in vitro</em>, <em>in vivo</em> studies and clinical trials, <em>Food Rev. Int.</em> <bold>38</bold>(8) (2022) 1668–1702; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1080/87559129.2020.1834577" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1080/87559129.2020.1834577</a>">https://doi.org/10.1080/87559129.2020.1834577</ext-link>
    Search in Google ScholarBack to article
  5. European Medicines Agency, European Union herbal monograph on <em>Matricaria recutita</em> L., flos, Committee on Herbal Medicinal Products (HMPC), London, 7 July 2015.
    Search in Google ScholarBack to article
  6. H. Schilcher, P. Imming and S. Goeters, <em>Active Chemical Constituents of Matricaria chamomilla L. syn. Chamomilla recutita (L.) Rauschert,</em> in <em>Chamomile-Industrial Profiles</em> (Ed. R. Franke and H. Schilcher), CRC Press, Boca Raton 2005, pp. 55–76.
    Search in Google ScholarBack to article
  7. M. Saeedi, M. Khanavi, K. Shahsavari and A. Manayi, <em>Matricaria chamomilla</em>: An updated review on biological activities of the plant and constituents, <em>Res. J. Pharmacogn.</em> <bold>11</bold>(1) (2024) 109–136; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.22127/RJP.2023.404256.2145" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.22127/RJP.2023.404256.2145</a>">https://doi.org/10.22127/RJP.2023.404256.2145</ext-link>
    Search in Google ScholarBack to article
  8. B. Gosztola, S. Sárosi and É. Németh, Variability of the essential oil content and composition of chamomile (<em>Matricaria recutita</em> L.) affected by weather conditions, <em>Nat. Prod. Commun.</em> <bold>5</bold>(3) (2010) 465–470; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1177/1934578X1000500325" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1177/1934578X1000500325</a>">https://doi.org/10.1177/1934578X1000500325</ext-link>
    Search in Google ScholarBack to article
  9. B. Gosztola, É. Németh, A. Kozak, S. Sárosi and K. Szabó, Comparative evaluation of Hungarian chamomile (<em>Matricaria recutita</em> L.) populations, <em>Acta Hortic.</em> <bold>749</bold> (2007) 157–162; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.17660/ActaHortic.2007.749.16" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.17660/ActaHortic.2007.749.16</a>">https://doi.org/10.17660/ActaHortic.2007.749.16</ext-link>
    Search in Google ScholarBack to article
  10. R. Nurzyńska-Wierdak, The essential oil of <em>Chamomilla recutita</em> (L.) Rausch. cultivated and wild growing in Poland, <em>Curr. Issues Pharm. Med. Sci.</em> <bold>24</bold>(2) (2011) 195–204; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="https://czasopisma.umlub.pl/curipms/article/view/3022">https://czasopisma.umlub.pl/curipms/article/view/3022</ext-link>
    Search in Google ScholarBack to article
  11. C. Formisano, S. Delfine, F. Oliviero, G. C. Tenore, D. Rigano and F. Senatore, Correlation among environmental factors, chemical composition and antioxidative properties of essential oil and extracts of chamomile (<em>Matricaria chamomilla</em> L.) collected in Molise (south-central Italy), <em>Ind. Crops Prod.</em> <bold>63</bold> (2015) 256–263; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1016/j.indcrop.2014.09.042" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1016/j.indcrop.2014.09.042</a>">https://doi.org/10.1016/j.indcrop.2014.09.042</ext-link>
    Search in Google ScholarBack to article
  12. K. D. Giannoulis, C.-A. Kamvoukou and N. G. Eleni Wogiatzi, <em>Matricaria chamomilla</em> L. (German chamomile) flower yield and essential oil affected by irrigation and nitrogen fertilization, <em>Emir. J. Food Agric.</em> <bold>32</bold>(5) (2020) 328–335; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.9755/ejfa.2020.v32.i5.2099" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.9755/ejfa.2020.v32.i5.2099</a>">https://doi.org/10.9755/ejfa.2020.v32.i5.2099</ext-link>
    Search in Google ScholarBack to article
  13. P. Mavandi, M. H. Assareh, A. Dehshiri, H. Rezadoost and V. Abdossi, Evaluation of morpho-physiological traits and essential oil production in Iranian genotypes and foreign varieties of chamomile (<em>Matricaria chamomilla</em> L.) through multivariate analyses, <em>Sci. Hortic.</em> <bold>282</bold> (2021) Article ID 110017 (8 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1016/j.scienta.2021.110017" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1016/j.scienta.2021.110017</a>">https://doi.org/10.1016/j.scienta.2021.110017</ext-link>
    Search in Google ScholarBack to article
  14. T. Benković-Lačić, I. Orehovec, K. Mirosavljević, R. Benković, S. Ćavar Zeljković, N. Štefelová, P. Tarkowski and B. Salopek-Sondi, Effect of drying methods on chemical profile of chamomile (<em>Matricaria chamomilla</em> L.) flowers, <em>Sustainability</em> <bold>15</bold>(21) (2023) Article ID 15373 (13 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.3390/su152115373" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.3390/su152115373</a>">https://doi.org/10.3390/su152115373</ext-link>
    Search in Google ScholarBack to article
  15. T. Kutsyk, I. Gorlachova and L. Hlushchenko, To the problem of influence of storage conditions on quality of medicinal plant raw materials, <em>Bull. Agric. Sci</em>. <bold>6</bold> (2018) 61–66; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.31073/agrovisnyk201806-10" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.31073/agrovisnyk201806-10</a>">https://doi.org/10.31073/agrovisnyk201806-10</ext-link>
    Search in Google ScholarBack to article
  16. A. Wesolowska, M. Grzeszczuk and D. Kulpa, Propagation method and distillation apparatus type affect essential oil from different parts of <em>Matricaria recutita</em> L. plants, <em>J. Essent. Oil-Bear. Plants</em> <bold>18</bold>(1) (2015) 179–194; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1080/0972060X.2014.895210" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1080/0972060X.2014.895210</a>">https://doi.org/10.1080/0972060X.2014.895210</ext-link>
    Search in Google ScholarBack to article
  17. Council of Europe, European Directorate for the Quality of Medicines &amp; HealthCare (EDQM), <em>European Pharmacopoeia</em>, 11th ed., Strasbourg 2022; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="https://pheur.edqm.eu/app/11-7/content/11-7/0404E.htm?highlight=on&amp;terms%5B%5D=matricariae;">https://pheur.edqm.eu/app/11-7/content/11-7/0404E.htm?highlight=on&amp;terms%5B%5D=matricariae;</ext-link> <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="https://pheur.edqm.eu/app/11-7/content/11-7/20812E.htm?highlight=on&amp;terms%5B%5D=essential&amp;terms%5B%5D=essential%20oils%20in%20herbal%20drugs&amp;terms%5B%5D=in&amp;terms%5B%5D=herbal;">https://pheur.edqm.eu/app/11-7/content/11-7/20812E.htm?highlight=on&amp;terms%5B%5D=essential&amp;terms%5B%5D=essential%20oils%20in%20herbal%20drugs&amp;terms%5B%5D=in&amp;terms%5B%5D=herbal;</ext-link> <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="https://pheur.edqm.eu/app/11-7/content/11-7/1217E.htm?highlight=on&amp;terms%5B%5D=sambuci%20flos;">https://pheur.edqm.eu/app/11-7/content/11-7/1217E.htm?highlight=on&amp;terms%5B%5D=sambuci%20flos;</ext-link> <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="https://pheur.edqm.eu/app/11-7/content/11-7/1836E.htm?highlight=on&amp;terms%5B%5D=matricariae%20aetheroleum;">https://pheur.edqm.eu/app/11-7/content/11-7/1836E.htm?highlight=on&amp;terms%5B%5D=matricariae%20aetheroleum;</ext-link> last access date August 15, 2025.
    Search in Google ScholarBack to article
  18. Allied Market Research, <em>Herbal Tea Market Size, Share, Competitive Landscape and Trend Analysis Report, by Type, by Packaging, by Distribution Channel: Global Opportunity Analysis and Industry Forecast, 2022 – 2032</em>, December 2023; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="https://www.alliedmarketresearch.com/herbal-tea-market;">https://www.alliedmarketresearch.com/herbal-tea-market;</ext-link> last access date May 2, 2025.
    Search in Google ScholarBack to article
  19. H. Wang, Y. Chen, L. Wang, Q. Liu, S. Yang and C. Wang, Advancing herbal medicine: Enhancing product quality and safety through robust quality control practices, <em>Front. Pharmacol</em>. <bold>14</bold> (2023) Article ID 1265178 (16 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.3389/fphar.2023.1265178" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.3389/fphar.2023.1265178</a>">https://doi.org/10.3389/fphar.2023.1265178</ext-link>
    Search in Google ScholarBack to article
  20. E. J. Abraham and J. J. Kellogg, Chemometric-guided approaches for profiling and authenticating botanical materials, <em>Front. Nutr.</em> <bold>8</bold> (2021) Article ID 780228 (24 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.3389/fnut.2021.780228" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.3389/fnut.2021.780228</a>">https://doi.org/10.3389/fnut.2021.780228</ext-link>
    Search in Google ScholarBack to article
  21. S. Syafri, I. Jaswir, F. Yusof, A. Rohman, M. Ahda and D. Hamidi, The use of instrumental technique and chemometrics for essential oil authentication: a review, <em>Results Chem</em>. <bold>4</bold> (2022), Article ID 100622 (10 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1016/j.rechem.2022.100622" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1016/j.rechem.2022.100622</a>">https://doi.org/10.1016/j.rechem.2022.100622</ext-link>
    Search in Google ScholarBack to article
  22. S. Das, B. Horváth, S. Šafranko, S. Jokić, A. Széchenyi and T. Kőszegi, Antimicrobial activity of chamomile essential oil: Effect of different formulations, <em>Molecules</em> <bold>24</bold> (2019) Article ID 4321 (17 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.3390/molecules24234321" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.3390/molecules24234321</a>">https://doi.org/10.3390/molecules24234321</ext-link>
    Search in Google ScholarBack to article
  23. R. P. Adams, <em>Identification of Essential Oil Components by Gas Chromatography/Mass Spectrometry</em>, 4<sup>th</sup> ed., Allured Publishing Corporation, Carol Stream 2007.
    Search in Google ScholarBack to article
  24. H. van Den Dool and P. D. Kratz, A generalization of the retention index system including linear temperature programmed gas-liquid partition chromatography, <em>J. Chromatogr. A</em> <bold>11</bold> (1963) 463–471; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1016/S0021-9673(01)80947-X" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1016/S0021-9673(01)80947-X</a>">https://doi.org/10.1016/S0021-9673(01)80947-X</ext-link>
    Search in Google ScholarBack to article
  25. A. Raal, A. Orav, T. Püssa, C. Valner, B. Malmiste and E. Arak, Content of essential oil, terpenoids and polyphenols in commercial chamomile (<em>Chamomilla recutita</em> L. Rauschert) teas from different countries, <em>Food Chem.</em> <bold>131</bold>(3) (2012) 632–638; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1016/j.foodchem.2011.09.042" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1016/j.foodchem.2011.09.042</a>">https://doi.org/10.1016/j.foodchem.2011.09.042</ext-link>
    Search in Google ScholarBack to article
  26. A. Orav, A. Raal and E. Arak, Content and composition of the essential oil of <em>Chamomilla recutita</em> (L.) Rauschert from some European countries, <em>Nat. Prod. Res.</em> <bold>24</bold>(1) (2010) 48–55; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1080/14786410802560690" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1080/14786410802560690</a>">https://doi.org/10.1080/14786410802560690</ext-link>
    Search in Google ScholarBack to article
  27. I. Šalamon and I. Sudimáková, Quality of chamomile teas-essential oil content and its composition, <em>Acta Hortic.</em> <bold>749</bold> (2007) 181–186; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.17660/ActaHortic.2007.749.19" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.17660/ActaHortic.2007.749.19</a>">https://doi.org/10.17660/ActaHortic.2007.749.19</ext-link>
    Search in Google ScholarBack to article
  28. B. Tischer, R. G. Vendruscolo, R. Wagner, C. R. Menezes, C. S. Barin, S. R. Giacomelli, J. M. Budel and J. S. Barin, Effect of grinding method on the analysis of essential oil from <em>Baccharis articulata</em> (Lam.) Pers., <em>Chem. Pap.</em> <bold>71</bold>(6) (2017) 753–761; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1007/s11696-016-0052-0" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1007/s11696-016-0052-0</a>">https://doi.org/10.1007/s11696-016-0052-0</ext-link>
    Search in Google ScholarBack to article
  29. W. Letchamo, Effect of storage temperatures and duration on the essential oil and flavonoids of chamomile, <em>J. Herbs Spices Med. Plants</em> <bold>1</bold>(3) (1993) 13–26; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1300/J044v01n03_03" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1300/J044v01n03_03</a>">https://doi.org/10.1300/J044v01n03_03</ext-link>
    Search in Google ScholarBack to article
  30. E. Guzelmeric, P. Ristivojević, I. Vovk, D. Milojković-Opsenica and E. Yesilada, Quality assessment of marketed chamomile tea products by a validated HPTLC method combined with multivariate analysis, <em>J. Pharm. Biomed. Anal</em>. <bold>132</bold> (2017) 35–45; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1016/j.jpba.2016.09.030" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1016/j.jpba.2016.09.030</a>">https://doi.org/10.1016/j.jpba.2016.09.030</ext-link>
    Search in Google ScholarBack to article
  31. A. Pérez-Vásquez, A. Peña-Álvarez and R. Mata, GC-MS and chemometric analysis of the essential oils obtained from Mexican commercial <em>Chamomilla recutita</em> teas, <em>Chem. Biodivers.</em> <bold>21</bold>(6) (2024) e202400333 (6 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1002/cbdv.202400333" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1002/cbdv.202400333</a>">https://doi.org/10.1002/cbdv.202400333</ext-link>
    Search in Google ScholarBack to article
  32. G. Stanić, N. Blažević, I. Bošnjak and Z. Ostojić, Essential oil of chamomile cultivated in Slavonija, <em>Farm. Glas.</em> <bold>56</bold>(5) (2000) 139–147.
    Search in Google ScholarBack to article
  33. B. Gosztola, E. Németh, S. Sárosi, K. Szabó and A. Kozák, Comparative evaluation of chamomile (<em>Matricaria recutita</em> L.) populations from different origin, <em>Int. J. Hortic. Sci.</em> <bold>12</bold>(1) (2006) 91–95; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.31421/IJHS/12/1/629" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.31421/IJHS/12/1/629</a>">https://doi.org/10.31421/IJHS/12/1/629</ext-link>
    Search in Google ScholarBack to article
  34. P. Rubiolo, F. Belliardo, C. Cordero, E. Liberto, B. Sgorbini and C. Bicchi, Headspace-solid-phase microextraction fast GC in combination with principal component analysis as a tool to classify different chemotypes of chamomile flower-heads (<em>Matricaria recutita</em> L.), <em>Phytochem. Anal.</em> <bold>17</bold>(4) (2006) 217–225; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1002/pca.919" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1002/pca.919</a>">https://doi.org/10.1002/pca.919</ext-link>
    Search in Google ScholarBack to article
  35. I. Salamon, Slovak chamomile varieties and their comparison of natural components, <em>Curr. Perspect. Med. Aromat. Plants</em> <bold>2</bold>(2) (2019) 59–65; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.38093/CUPMAP.656099" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.38093/CUPMAP.656099</a>">https://doi.org/10.38093/CUPMAP.656099</ext-link>
    Search in Google ScholarBack to article
  36. I. A. Saddye, A. Celik, A. Kan and Y. Kan, Essential oil yield and compositions of chamomile (<em>Matricaria chamomilla</em> L.) cultivated in different provinces of Turkey, <em>J. Agric. Environ. Food Sci.</em> <bold>2</bold>(1) (2018) 202–203; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.31015/jaefs.18037" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.31015/jaefs.18037</a>">https://doi.org/10.31015/jaefs.18037</ext-link>
    Search in Google ScholarBack to article
  37. M. Höferl, J. Wanner, N. Tabanca, A. Ali, V. Gochev, E. Schmidt, V. Kaul, V. Singh and L. Jirovetz, Biological activity of <em>Matricaria chamomilla</em> essential oils of various chemotypes, <em>Planta Med. Int. Open</em> <bold>7</bold> (2020) e114–e121; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1055/a-1186-2400" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1055/a-1186-2400</a>">https://doi.org/10.1055/a-1186-2400</ext-link>
    Search in Google ScholarBack to article
  38. M. Tomić, V. Popović, S. Petrović, R. Stepanović-Petrović, A. Micov, M. Pavlović-Drobac and M. Couladis, Antihyperalgesic and antiedematous activities of bisabolol-oxides-rich matricaria oil in a rat model of inflammation, <em>Phytother. Res.</em> <bold>28</bold> (2014) 759–766; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1002/ptr.5057" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1002/ptr.5057</a>">https://doi.org/10.1002/ptr.5057</ext-link>
    Search in Google ScholarBack to article
  39. W. Akram, S. Ahmed, M. Rihan, S. Arora, M. Khalid, S. Ahmad, F. Ahmad, S. Haque and R. Vashishth, An updated comprehensive review of the therapeutic properties of chamomile (<em>Matricaria chamomilla</em> L.), <em>Int. J. Food Prop.</em> <bold>27</bold> (2024) 133–164; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1080/10942912.2023.2293661" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1080/10942912.2023.2293661</a>">https://doi.org/10.1080/10942912.2023.2293661</ext-link>
    Search in Google ScholarBack to article
  40. D. Lairikyengbam, B. Wetterauer, M. Schmiech, B. Jahraus, H. Kirchgessner, P. Wetterauer, K. Berschneider, V. Beier, B. Niesler, E. Balta and Y. Samstag, Comparative analysis of whole plant, flower and root extracts of <em>Chamomilla recutita</em> L. and characteristic pure compounds reveals differential anti-inflammatory effects on human T cells, <em>Front. Immunol</em>. <bold>15</bold> (2024) Article ID 1388962 (20 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.3389/fimmu.2024.1388962" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.3389/fimmu.2024.1388962</a>">https://doi.org/10.3389/fimmu.2024.1388962</ext-link>
    Search in Google ScholarBack to article
  41. H. Ahmadpourmir, S. F. Taghizadeh, Y. Mezhuev, A. A. Salavati Nik, M. Tzatzarakis, A. Tsatsakis and R. Rezaee, A review of approaches developed for spiroether synthesis, <em>Top. Curr. Chem</em>. <bold>383</bold> (2025) Article ID 24 (41 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1007/s41061-025-00508-w" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1007/s41061-025-00508-w</a>">https://doi.org/10.1007/s41061-025-00508-w</ext-link>
    Search in Google ScholarBack to article
  42. M. Kharbach, I. Marmouzi, M. El Jemli, A. Bouklouze and Y. Vander Heyden, Recent advances in untargeted and targeted approaches applied in herbal-extracts and essential-oils fingerprinting – A review, <em>J. Pharm. Biomed. Anal</em>. <bold>177</bold> (2020) Article ID 112849 (52 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1016/j.jpba.2019.112849" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1016/j.jpba.2019.112849</a>">https://doi.org/10.1016/j.jpba.2019.112849</ext-link>
    Search in Google ScholarBack to article
  43. E. Noviana, G. Indrayanto and A. Rohman, Advances in fingerprint analysis for standardization and quality control of herbal medicines, <em>Front. Pharmacol</em>. <bold>13</bold> (2022) Article ID 853023 (21 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.3389/fphar.2022.853023" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.3389/fphar.2022.853023</a>">https://doi.org/10.3389/fphar.2022.853023</ext-link>
    Search in Google ScholarBack to article
  44. M. Hrki, M. S. Murtic and S. Murtic, A quality evaluation of chamomile and mint teas commonly consumed in Bosnia and Herzegovina, <em>J. Excip. Food Chem.</em> <bold>12</bold>(3) (2021) 41–48.
    Search in Google ScholarBack to article
  45. F. G. Miguel, A. H. Cavalheiro, N. F. Spinola, D. L. Ribeiro, G. R. M. Barcelos, L. M. G. Antunes, J. I. Hori, F. Marquele-Oliveira, B. A. Rocha and A. A. Berretta, Validation of a RP-HPLC-DAD method for chamomile (<em>Matricaria recutita</em>) preparations and assessment of the marker, apigenin-7-gluco-side, safety and anti-inflammatory effect, <em>Evid. Based Complement. Altern. Med.</em> <bold>2015</bold> (2015) Article ID 828437 (9 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1155/2015/828437" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1155/2015/828437</a>">https://doi.org/10.1155/2015/828437</ext-link>
    Search in Google ScholarBack to article
  46. N. Tsivelika, M. Irakli, A. Mavromatis, P. Chatzopoulou and A. Karioti, Phenolic profile by HPLC-PDA-MS of Greek chamomile populations and commercial varieties and their antioxidant activity, <em>Foods</em> <bold>10</bold>(10) (2021) Article ID 2345 (16 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.3390/foods10102345" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.3390/foods10102345</a>">https://doi.org/10.3390/foods10102345</ext-link>
    Search in Google ScholarBack to article
  47. A. Viapiana, W. Struck-Lewicka, P. Konieczynski, M. Wesolowski and R. Kaliszan, An approach based on HPLC-fingerprint and chemometrics to quality consistency evaluation of <em>Matricaria chamomilla</em> L. commercial samples, <em>Front. Plant Sci.</em> <bold>7</bold> (2016) Article ID 1561 (11 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.3389/fpls.2016.01561" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.3389/fpls.2016.01561</a>">https://doi.org/10.3389/fpls.2016.01561</ext-link>
    Search in Google ScholarBack to article
  48. N. Mulinacci, A. Romani, P. Pinelli, F. F. Vincieri and D. Prucher, Characterization of <em>Matricaria recutita</em> L. flower extracts by HPLC-MS and HPLC-DAD analysis, <em>Chromatographia</em> <bold>51</bold> (2000) 301–307; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1007/bf02490607" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1007/bf02490607</a>">https://doi.org/10.1007/bf02490607</ext-link>
    Search in Google ScholarBack to article
  49. C. C. Aleman and P. A. A. Marques, Irrigation and organic fertilization on the production of essential oil and flavonoid in chamomile, <em>Rev. Bras. Eng. Agríc. Ambient.</em> <bold>20</bold> (2016) 1045–1050; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1590/1807-1929/agriambi.v20n12p1045-1050" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1590/1807-1929/agriambi.v20n12p1045-1050</a>">https://doi.org/10.1590/1807-1929/agriambi.v20n12p1045-1050</ext-link>
    Search in Google ScholarBack to article
  50. V. Švehlíková and M. Repčák, Variation of apigenin quantity in diploid and tetraploid <em>Chamomilla recutita</em> (L.) Rauschert, <em>Plant Biol</em>. <bold>2</bold> (2000) 403–407; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1055/s-2000-5957" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1055/s-2000-5957</a>">https://doi.org/10.1055/s-2000-5957</ext-link>
    Search in Google ScholarBack to article
  51. K. Baghalian, S. Abdoshah, F. Khalighi-Sigaroodi and F. Paknejad, Physiological and phytochemical response to drought stress of German chamomile (<em>Matricaria recutita</em> L.), <em>Plant Physiol. Biochem</em>. <bold>49</bold> (2011) 201–207; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1016/j.plaphy.2010.11.010" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1016/j.plaphy.2010.11.010</a>">https://doi.org/10.1016/j.plaphy.2010.11.010</ext-link>
    Search in Google ScholarBack to article
  52. N. Harbourne, J. C. Jacquier and D. O’Riordan, Optimisation of the extraction and processing conditions of chamomile (<em>Matricaria chamomilla</em> L.) for incorporation into a beverage, <em>Food Chem.</em> <bold>115</bold>(1) (2009) 15–19; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1016/j.foodchem.2008.11.059" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1016/j.foodchem.2008.11.059</a>">https://doi.org/10.1016/j.foodchem.2008.11.059</ext-link>
    Search in Google ScholarBack to article
  53. R. R. Rungsirisakun and P. Boonyaritthongchai, Effect of drying methods on the active compounds of chamomile tea, <em>Acta Hortic.</em> <bold>1208</bold> (2018) 437–442; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.17660/actahortic.2018.1208.60" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.17660/actahortic.2018.1208.60</a>">https://doi.org/10.17660/actahortic.2018.1208.60</ext-link>
    Search in Google ScholarBack to article
  54. N. Başaran, D. Paslı and A. A. Başaran, Unpredictable adverse effects of herbal products, <em>Food Chem. Toxicol.</em> <bold>159</bold> (2022) Article ID 112762 (8 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1016/j.fct.2021.112762" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1016/j.fct.2021.112762</a>">https://doi.org/10.1016/j.fct.2021.112762</ext-link>
    Search in Google ScholarBack to article
  55. M. Ostovar, Z. Rezaee, S. M. Najibi and M. H. Hashempur, Chamomile: A systematic review of adverse events, <em>Complement. Ther. Med</em>. <bold>91</bold> (2025) Article ID 103192 (11 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1016/j.ctim.2025.103192" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1016/j.ctim.2025.103192</a>">https://doi.org/10.1016/j.ctim.2025.103192</ext-link>
    Search in Google ScholarBack to article
  56. B. Avula, Y. H. Wang, M. Wang, C. Avonto, J. Zhao, T. J. Smillie, D. Rua and I. A. Khan, Quantitative determination of phenolic compounds by UHPLC-UV-MS and use of partial least-square discriminant analysis to differentiate chemo-types of Chamomile/Chrysanthemum flower heads, <em>J. Pharm. Biomed. Anal</em>. <bold>88</bold> (2014) 278–288; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1016/j.jpba.2013.08.037" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1016/j.jpba.2013.08.037</a>">https://doi.org/10.1016/j.jpba.2013.08.037</ext-link>
    Search in Google ScholarBack to article
  57. M. Wang, B. Avula, Y. H. Wang, J. Zhao, C. Avonto, J. F. Parcher, V. Raman, J. A. Zweigenbaum, P. L. Wylie, and I. A. Khan, An integrated approach utilising chemometrics and GC/MS for classification of chamomile flowers, essential oils and commercial products, <em>Food Chem</em>. <bold>152</bold> (2014) 391–398; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1016/j.foodchem.2013.11.118" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1016/j.foodchem.2013.11.118</a>">https://doi.org/10.1016/j.foodchem.2013.11.118</ext-link>
    Search in Google ScholarBack to article
DOI: https://doi.org/10.2478/acph-2025-0028 | Journal eISSN: 1846-9558 | Journal ISSN: 1330-0075
Journal RSS Feed
Language: English
Page range: 331 - 355
Accepted on: Sep 11, 2025
Published on: Oct 10, 2025
Published by: Croatian Pharmaceutical Society
In partnership with: Paradigm Publishing Services
Publication frequency: 4 times per year
Keywords:
chemometrics,
quality control,
essential oil,
apigenin-7-glucoside,
chamomile tea
Related subjects:
Pharmacy,
Pharmacy, other

© 2025 Biljana Blažeković, Ines Job Čičin-Mašansker, Marija Kindl, Lucia Mahovlić, Sanda Vladimir-Knežević, published by Croatian Pharmaceutical Society
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Previous articleVolume 75 (2025): Issue 3 (September 2025)Next article