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From in vitro studies to product information useful for patients: Evaluation of physical properties and the stability of nasal spray devices containing hydroxypropyl methylcellulose-based liquid and powder formulations Cover

From in vitro studies to product information useful for patients: Evaluation of physical properties and the stability of nasal spray devices containing hydroxypropyl methylcellulose-based liquid and powder formulations

Acta Pharmaceutica
Volume 75 (2025): Issue 3 (September 2025)
By:
Open Access
|Oct 2025

References

  1. S. Le Guellec, S. Ehrmann and L. Vecellio, <em>In vitro – in vivo</em> correlation of intranasal drug deposition, <em>Adv. Drug Deliv. Rev.</em> <bold>170</bold> (2021) 340–352; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1016/j.addr.2020.09.002" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1016/j.addr.2020.09.002</a>">https://doi.org/10.1016/j.addr.2020.09.002</ext-link>
    Search in Google ScholarBack to article
  2. K. Bentley and R. Stanton, Hydroxypropyl methylcellulose-based nasal sprays effectively inhibit in vitro SARS-CoV-2 infection and spread, <em>Viruses</em> <bold>13</bold>(12) (2021) Article ID 2345 (10 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.3390/v13122345" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.3390/v13122345</a>">https://doi.org/10.3390/v13122345</ext-link>
    Search in Google ScholarBack to article
  3. D. Schütz, C. Conzelmann, G. Fois, R. Groß, T. Weil, L. Wettstein, S. Stenger, A. Zelikin, T. K. Hoffmann, M. Frick, J. A. Müller and J. Münch, Carrageenan-containing over-the-counter nasal and oral sprays inhibit SARS-CoV-2 infection of airway epithelial cultures, <em>Am. J. Physiol. Lung Cell Mol. Physiol.</em> <bold>320</bold>(5) (2021) 750–766; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1152/ajplung.00552.2020" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1152/ajplung.00552.2020</a>">https://doi.org/10.1152/ajplung.00552.2020</ext-link>
    Search in Google ScholarBack to article
  4. D. Hull, P. Rennie, A. Noronha, C. Poore, N. Harrington, V. Fearnley and D. Passàli, Effects of creating a non-specific, virus-hostile environment in the nasopharynx on symptoms and duration of common cold, <em>Acta Otorhinolaryngol. Ital.</em> <bold>27</bold>(2) (2007) 73–77.
    Search in Google ScholarBack to article
  5. M. Morokutti-Kurz, M. Fröba, P. Graf, M. Große, A. Grassauer, J. Auth, U. Schubert and E. Prieschl-Grassauer, Iota-carrageenan neutralizes SARS-CoV-2 and inhibits viral replication in vitro, <em>PLoS One</em> <bold>16</bold>(2) (2021) e0237480 (13 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="https://doi.org/https://doi.org/10.1371/journal.pone.0237480">https://doi.org/https://doi.org/10.1371/journal.pone.0237480</ext-link>
    Search in Google ScholarBack to article
  6. Y. Jang, H. Shin, M. K. Lee, O. S. Kwon, J. S. Shin, Y. I. Kim, C. W. Kim, H. R. Lee and M. Kim, Antiviral activity of lambda-carrageenan against influenza viruses and severe acute respiratory syndrome coronavirus 2, <em>Sci. Rep</em>. <bold>11</bold>(1) (2021) Article ID 821 (12 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1038/s41598-020-80896-9" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1038/s41598-020-80896-9</a>">https://doi.org/10.1038/s41598-020-80896-9</ext-link>
    Search in Google ScholarBack to article
  7. A. Leibbrandt, C. Meier, M. König-Schuster, R. Weinmüllner, D. Kalthoff, B. Pflugfelder, P. Graf, B. Frank-Gehrke, M. Beer, T. Fazekas, H. Unger, E. Prieschl-Grassauer and A. Grassauer, Iota-carrageenan is a potent inhibitor of influenza A virus infection, <em>PLoS One</em> <bold>5</bold>(12) (2010) e14320 (11 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="https://doi.org/10.1371%2Fjournal.pone.0014320">https://doi.org/10.1371%2Fjournal.pone.0014320</ext-link>
    Search in Google ScholarBack to article
  8. A. J. Hickey and S. R. da Rocha, <em>Pharmaceutical Inhalation Aerosol Technology,</em> CRC Press, Boca Raton 2019; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1201/9780429055201" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1201/9780429055201</a>">https://doi.org/10.1201/9780429055201</ext-link>
    Search in Google ScholarBack to article
  9. T. Imsuwansri, T. Jongthitinon, N. Pojdoung, N. Meesiripan, S. Sakarin, C. Boonkrai, T. Wong-tangprasert, T. Phakham, T. Audomsun, C. Attakitbancha, P. Saelao, P. Muanwien, M. T. Tian, S. Tongchusak, B. Sangruji, D. L. Wannigama, C. Sawangmake, W. Rodprasert, Q. D. Le, S. D. Purbantoro, K. Vasuntrarak, S. Nantavisai, S. Sirilak, B. Uppapong, S. Sapsutthipas, S. Trisiriwanich, T. Somporn, A. Usoo, N. Mingngamsup, S. Phumiamorn, P. Aumklad, K. Arunprasert, P. Patrojanasophon, P. Opanasopit, N. Pesirikan, L. Nitisaporn, J. Pitchayakorn, T. Narkthong, B. Mahong, K. Chaiyo, K. Srisutthisamphan, R. Viriyakitkosol, S. Aeumjaturapat, A. Jongkaewwattana, S. Bunnag and T. Pisitkun, Assessment of safety and intranasal neutralizing antibodies of HPMC-based human anti-SARS-CoV-2 IgG1 nasal spray in healthy volunteers, <em>Sci. Rep</em>. <bold>13</bold> (2023) Article ID 15648 (12 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="https://doi.org10.1038/s41598-023-42539-7">https://doi.org10.1038/s41598-023-42539-7</ext-link>
    Search in Google ScholarBack to article
  10. T. A. Popov, J. Emberlin, P. Josling and A. Seifalian, In vitro and in vivo evaluation of the efficacy and safety of powder hydroxypropylmethylcellulose as nasal mucosal barrier, <em>Med. Devices</em> <bold>13</bold> (2020) 107–113; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="https://doi.org/10.2147%2FMDER.S236104">https://doi.org/10.2147%2FMDER.S236104</ext-link>
    Search in Google ScholarBack to article
  11. N. Hunt, L. Suleman, P. D. Josling and T. A. Popov, Virucidal activity of Nasaleze<sup>®</sup> Cold &amp; Flu Blocker and Nasaleze<sup>®</sup> Travel in cell cultures infected with human pathogenic coronavirus 229-E, <em>bioRxiv</em> 23 (2021) (16 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1101/2021.09.23.461483" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1101/2021.09.23.461483</a>">https://doi.org/10.1101/2021.09.23.461483</ext-link>
    Search in Google ScholarBack to article
  12. S. Perez-Robles, C. Carotenuto and M. Minale, HPMC hydrogel formation mechanisms unveiled by the evaluation of the activation energy, <em>Polymers</em> <bold>14</bold>(3) (2022) Article ID 635 (10 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.3390/polym14030635" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.3390/polym14030635</a>">https://doi.org/10.3390/polym14030635</ext-link>
    Search in Google ScholarBack to article
  13. U.S. Department of Health and Human Services FaDA, Center for Drug Evaluation and Research (CDER) (2002) Guidance for Industry: Nasal Spray and Inhalation Solution, Suspension, and Spray Drug Products – Chemistry, Manufacturing, and Controls Documentation
    Search in Google ScholarBack to article
  14. A. Baldelli, C. Y. J. Wong, H. Oguzlu, H. Gholizadeh, Y. Guo, H. X. Ong, A. Singh, D. Traini and A. Pratap-Singh, Nasal delivery of encapsulated recombinant ACE2 as a prophylactic drug for SARS-CoV-2, <em>Int. J. Pharm</em>. <bold>655</bold> (2024) Article ID 124009 (13 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1016/j.ijpharm.2024.124009" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1016/j.ijpharm.2024.124009</a>">https://doi.org/10.1016/j.ijpharm.2024.124009</ext-link>
    Search in Google ScholarBack to article
  15. C. Y. J. Wong, A. Baldelli, O. Tietz, J. van der Hoven, J. Suman, H. X. Ong and D. Traini, An overview of in vitro and in vivo techniques for characterization of intranasal protein and peptide formulations for brain targeting, <em>Int. J. Pharm</em>. <bold>654</bold> (2024) Article ID 123922 (12 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1016/j.ijpharm.2024.123922" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1016/j.ijpharm.2024.123922</a>">https://doi.org/10.1016/j.ijpharm.2024.123922</ext-link>
    Search in Google ScholarBack to article
  16. B. Sipos, I. Csóka, N. Szivacski, M. Budai-Szűcs, Z. Schelcz, I. Zupkó, P. Szabó-Révész, B. Volk and G. Katona, Mucoadhesive meloxicam-loaded nanoemulsions: Development, characterization and nasal applicability studies, <em>Eur. J. Pharm. Sci.</em> <bold>175</bold> (2022) Article ID 106229 (10 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1016/j.ejps.2022.106229" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1016/j.ejps.2022.106229</a>">https://doi.org/10.1016/j.ejps.2022.106229</ext-link>
    Search in Google ScholarBack to article
  17. S. Trows, K. Wuchner, R. Spycher and H. Steckel, Analytical challenges and regulatory requirements for nasal drug products in europe and the U.S., <em>Pharmaceutics</em> <bold>6</bold>(2) (2014) 195–219; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.3390/pharmaceutics6020195" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.3390/pharmaceutics6020195</a>">https://doi.org/10.3390/pharmaceutics6020195</ext-link>
    Search in Google ScholarBack to article
  18. F. Laffleur and B. Bauer, Progress in nasal drug delivery systems, <em>Int. J. Pharm.</em> <bold>607</bold> (2021) Article ID 120994; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1016/j.ijpharm.2021.120994" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1016/j.ijpharm.2021.120994</a>">https://doi.org/10.1016/j.ijpharm.2021.120994</ext-link>
    Search in Google ScholarBack to article
  19. Y. Shin, R. Kokate, V. Desai, A. Bhushan and G. Kaushal, D-cycloserine nasal formulation development for anxiety disorders by using polymeric gels, <em>JDDT</em> <bold>12</bold> (2018) 142–153; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.5582/ddt.2018.01017" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.5582/ddt.2018.01017</a>">https://doi.org/10.5582/ddt.2018.01017</ext-link>
    Search in Google ScholarBack to article
  20. P. Rennie, P. Bowtell, D. Hull, D. Charbonneau, R. Lambkin-Williams and J. Oxford, Low pH gel intranasal sprays inactivate influenza viruses in vitro and protect ferrets against influenza infection, <em>Respir. Res.</em> <bold>8</bold> (2007) Article ID 38 (7 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1186/1465-9921-8-38" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1186/1465-9921-8-38</a>">https://doi.org/10.1186/1465-9921-8-38</ext-link>
    Search in Google ScholarBack to article
  21. M. E. Darnell, K. Subbarao, S. M. Feinstone and D. R. Taylor, Inactivation of the coronavirus that induces severe acute respiratory syndrome, SARS-CoV, <em>J. Virol. Methods</em> <bold>121</bold> (2004) 85–89; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1016/j.jviromet.2004.06.006" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1016/j.jviromet.2004.06.006</a>">https://doi.org/10.1016/j.jviromet.2004.06.006</ext-link>
    Search in Google ScholarBack to article
  22. K. Shmuel, M. Dalia, L. Tair and N. Yaakov, Low pH Hypromellose (Taffix) nasal powder spray could reduce SARS-CoV-2 infection rate post mass-gathering event at a highly endemic community: An observational prospective open label user survey, <em>Expert. Rev. Anti. Infect. Ther.</em> <bold>19</bold>(10) (2021) 1325–1330; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1080/14787210.2021.1908127" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1080/14787210.2021.1908127</a>">https://doi.org/10.1080/14787210.2021.1908127</ext-link>
    Search in Google ScholarBack to article
  23. T. L. Meister, D. Todt, Y. Brüggemann, J. Steinmann, S. Banava, F. H. H. Brill, J. Steinmann, S. Pfaender and E. Steinmann, Virucidal activity of nasal sprays against severe acute respiratory syndrome coronavirus-2, <em>J. Hosp. Infect</em>. <bold>120</bold> (2022) 9–13; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1016/j.jhin.2021.10.019" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1016/j.jhin.2021.10.019</a>">https://doi.org/10.1016/j.jhin.2021.10.019</ext-link>
    Search in Google ScholarBack to article
  24. A. Santomaso, P. Lazzaro and P. Canu, Powder flowability and density ratios: The impact of granules packing, <em>Chem. Eng. Sci.</em> <bold>58</bold>(13) (2003) 2857–2874; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1016/S0009-2509(03)00137-4" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1016/S0009-2509(03)00137-4</a>">https://doi.org/10.1016/S0009-2509(03)00137-4</ext-link>
    Search in Google ScholarBack to article
  25. Y. Pu, A. Goodey, X. Fang and K. Jacob, A comparison of the deposition patterns of different nasal spray formulations using a nasal cast, <em>Aerosol. Sci. Technol.</em> <bold>48</bold> (2014) 930–938; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1080/02786826.2014.931566" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1080/02786826.2014.931566</a>">https://doi.org/10.1080/02786826.2014.931566</ext-link>
    Search in Google ScholarBack to article
  26. R. J. A. Moakes, S. P. Davies, Z. Stamataki and L. M. Grover, Formulation of a composite nasal spray enabling enhanced surface coverage and prophylaxis of SARS-COV-2, <em>Adv. Mater.</em> <bold>33</bold>(26) (2021) Article ID 2008304 (11 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1002/adma.202008304" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1002/adma.202008304</a>">https://doi.org/10.1002/adma.202008304</ext-link>
    Search in Google ScholarBack to article
  27. P. Yimsiri and M. Mackley, Spin and dip coating of light-emitting polymer solutions: Matching experiment with modelling, <em>Chem. Eng. Sci.</em> <bold>61</bold> (2006) 3496–505; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1016/j.ces.2005.12.018" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1016/j.ces.2005.12.018</a>">https://doi.org/10.1016/j.ces.2005.12.018</ext-link>
    Search in Google ScholarBack to article
  28. A. Ghauri, I. Ghauri, A. M. A. Elhissi and W. Ahmed, <em>Advances in Medical and Surgical Engineering</em>, University of Central Lancashire, UK, Preston 2020.
    Search in Google ScholarBack to article
  29. C. M. Muntu, C. Avanti, H. Hayun and S. Surini, Stability study of spray freeze-dried insulin dry powder formulations used for nose-to-brain delivery, <em>J. Appl. Pharm. Sci.</em> <bold>10</bold>(13) (2023) 225–237; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.7324/JAPS.2023.148983" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.7324/JAPS.2023.148983</a>">https://doi.org/10.7324/JAPS.2023.148983</ext-link>
    Search in Google ScholarBack to article
  30. R. Popescu, M. V. Ghica, C. E. Dinu-Pîrvu, V. Anuta, D. Lupuleasa and L. Popa, New opportunity to formulate intranasal vaccines and drug delivery systems based on chitosan, <em>Int. J. Mol. Sci.</em> <bold>21</bold>(14) (2020) Article ID 5016 (23 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.3390/ijms21145016" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.3390/ijms21145016</a>">https://doi.org/10.3390/ijms21145016</ext-link>
    Search in Google ScholarBack to article
  31. A. G. Beule, Physiology and pathophysiology of respiratory mucosa of the nose and the paranasal sinuses, <em>GMS Curr. Top. Otorhinolaryngol. Head Neck Surg.</em> <bold>9</bold> (2010) Article ID 7 (24 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.3205/cto000071" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.3205/cto000071</a>">https://doi.org/10.3205/cto000071</ext-link>
    Search in Google ScholarBack to article
  32. R. Ghadermazi, S. Hamdipour, K. Sadeghi, R. Ghadermazi and A. Khosrowshahi Asl, Effect of various additives on the properties of the films and coatings derived from hydroxypropyl methylcellulose – A review, <em>Food. Sci. Nutr</em>. <bold>13</bold>(7) (2019) 3363–3377; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1002/fsn3.1206" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1002/fsn3.1206</a>">https://doi.org/10.1002/fsn3.1206</ext-link>
    Search in Google ScholarBack to article
  33. T. R. Sosnowski, P. Rapiejko, J. Sova and K. Dobrowolska, Impact of physicochemical properties of nasal spray products on drug deposition and transport in the pediatric nasal cavity model, <em>Int. J. Pharm.</em> <bold>574</bold> (2020) Article ID 118911; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1016/j.ijpharm.2019.118911" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1016/j.ijpharm.2019.118911</a>">https://doi.org/10.1016/j.ijpharm.2019.118911</ext-link>
    Search in Google ScholarBack to article
  34. S. Fang, X. Rui, Y. Zhang, Z. Yang and W. Wang, Comparative study of nasal cavity drug delivery efficiency with different nozzles in a 3D printed model, <em>PeerJ</em>. <bold>12</bold> (2024) e17227 (17 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.7717/peerj.17227" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.7717/peerj.17227</a>">https://doi.org/10.7717/peerj.17227</ext-link>
    Search in Google ScholarBack to article
  35. Y. Pu, A. P. Goodey, X. Fang and K. Jacob, A comparison of the deposition patterns of different nasal spray formulations using a nasal cast, <em>AS&amp;T</em> <bold>48</bold>(9) (2014) 930–938; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1080/02786826.2014.931566" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1080/02786826.2014.931566</a>">https://doi.org/10.1080/02786826.2014.931566</ext-link>
    Search in Google ScholarBack to article
  36. M. Gao, X. Shen and S. Mao, Factors influencing drug deposition in thenasal cavity upon delivery via nasal sprays, <em>J. Pharm. Investig.</em> <bold>50</bold>(3) (2020) 251–259; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1007/s40005-020-00482-z" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1007/s40005-020-00482-z</a>">https://doi.org/10.1007/s40005-020-00482-z</ext-link>
    Search in Google ScholarBack to article
  37. X. A. Si, M. Sami and J. Xi, Liquid film translocation significantly enhances nasal spray delivery to olfactory region: A numerical simulation study, <em>Pharmaceutics</em> <bold>13</bold>(6) (2021) Article ID 903 (19 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.3390/pharmaceutics13060903" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.3390/pharmaceutics13060903</a>">https://doi.org/10.3390/pharmaceutics13060903</ext-link>
    Search in Google ScholarBack to article
  38. J. Siu, J. van Strien, R. Campbell, P. Roberts, M. D. Tingle, K. Inthavong and R. G. Douglas, Comparison of sinus deposition from an aqueous nasal spray and pressurised MDI in a post-endoscopic sinus surgery nasal replica, <em>Pharm. Res.</em> <bold>39</bold>(2) (2022) 317–327; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1007/s11095-021-03129-2" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1007/s11095-021-03129-2</a>">https://doi.org/10.1007/s11095-021-03129-2</ext-link>
    Search in Google ScholarBack to article
  39. Q. Zhang, X. Li and B. R. Jasti, Role of physicochemical properties of some grades of hydroxypropyl methylcellulose on in vitro mucoadhesion, <em>Int. J. Pharm.</em> <bold>609</bold> (2021) Article ID 121218; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1016/j.ijpharm.2021.121218" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1016/j.ijpharm.2021.121218</a>">https://doi.org/10.1016/j.ijpharm.2021.121218</ext-link>
    Search in Google ScholarBack to article
  40. A. Utkarshini, F. Tiam and U. A. Remigius, <em>Recent Advances in Novel Drug Carrier Systems</em>, IntechO-pen, Rijeka 2012; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="https://doi/org/10.5772/2889">https://doi/org/10.5772/2889</ext-link>
    Search in Google ScholarBack to article
  41. J. Ehrick, S. Shah, C. Shaw, V. Kulkarni, I. Coowanitwong, S. De and J. Suman, Sterile product development, formulation, Process, Quality and Regulatory Considerations <em>AAPSPress</em> <bold>6</bold> (2013) 99–144.
    Search in Google ScholarBack to article
  42. P. G. Djupesland, Nasal drug delivery devices: characteristics and performance in a clinical perspective – A review, <em>Drug Deliv. Transl. Res.</em> <bold>3</bold> (2013) 42–62; <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.1007/s13346-012-0108-9" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.1007/s13346-012-0108-9</a>">https://doi.org/10.1007/s13346-012-0108-9</ext-link>
    Search in Google ScholarBack to article
  43. Y. Qin, J. Ye, P. Ohno, T. Nah and S. Martin, Temperature-dependent viscosity of organic materials characterized by atomic force microscope, <em>Atmosphere</em> <bold>12</bold>(11) (2021) Article ID 1476 (10 pages); <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="<a href="https://doi.org/10.3390/atmos12111476" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">https://doi.org/10.3390/atmos12111476</a>">https://doi.org/10.3390/atmos12111476</ext-link>
    Search in Google ScholarBack to article
DOI: https://doi.org/10.2478/acph-2025-0015 | Journal eISSN: 1846-9558 | Journal ISSN: 1330-0075
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Language: English
Page range: 469 - 487
Accepted on: May 16, 2025
Published on: Oct 10, 2025
Published by: Croatian Pharmaceutical Society
In partnership with: Paradigm Publishing Services
Publication frequency: 4 times per year
Keywords:
adhesive,
liquid,
polymer,
powder,
spray deposition
Related subjects:
Pharmacy,
Pharmacy, other

© 2025 Peerawas Kopongpanich, Veerakiet Boonkanokwong, Varin Titapiwatanakun, Rutthapol Sritharadol, published by Croatian Pharmaceutical Society
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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